DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LIMK1 and Takl1

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_732554.1	Gene:	Takl1 / 318725	FlyBaseID:	FBgn0046689	Length:	393	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	126/460 - (27%)
Similarity:	187/460 - (40%)	Gaps:	116/460 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 DLVIGEK-LGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIG 463
            ::.:.|| ||.|..|.|.|.|. |:.|:.| |.....:|..::|..:|:..|..:||.:|::.||
  Fly     9 EVKLSEKFLGAGSGGAVRKATF-QNQEIAV-KIFDFLEETIKKNAEREITHLSEIDHENVIRVIG 71

  Fly   464 VLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPW----PQRVRLARDIACGMSYLHSMN--IIHRD 522
            .....||.:::.||:..|.|...::...:   |    .|.||.|...|..::||||::  |:|||
  Fly    72 RASNGKKDYLLMEYLEEGSLHNYLYGDDK---WEYTVEQAVRWALQCAKALAYLHSLDRPIVHRD 133

  Fly   523 LNSMNCLV-REDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQR 586
            :...|.|: .:...:.:.|||||..:      |.|.|              ...||||
  Fly   134 IKPQNMLLYNQHEDLKICDFGLATDM------SNNKT--------------DMQGTLR------- 171

  Fly   587 RQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSL------N 645
                       :||||.:|.|||..|.||:||||||.|::.|..........||.:::      .
  Fly   172 -----------YMAPEAIKHLKYTAKCDVYSFGIMLWELMTRQLPYSHLENPNSQYAIMKAISSG 225

  Fly   646 QQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIETF 710
            ::...|...:.|||...::...|.|:||:.||.                         :.|||.|
  Fly   226 EKLPMEAVRSDCPEGIKQLMECCMDINPEKRPS-------------------------MKEIEKF 265

  Fly   711 -QEWYAS--SEDALSPTSQRSLNNLDE----LVKSAVD---SEISPVEKEKENMVIKPQDIP--- 762
             .|.|.|  .||.:.|        |||    :|...||   |.|..|:..:..:.......|
  Fly   266 LGEQYESGTDEDFIKP--------LDEDTVAVVTYHVDSSGSRIMRVDFWRHQLPSIRMTFPIVK 322

  Fly   763 -KSPHLGKDF-------SPSGER-----LRDSMRARRRQRFLGAQEERRNLTPDTESKERALKKA 814
             ::..|||..       :..|:|     .:|:.|...|....|.:|.||..........||:||.
  Fly   323 REAERLGKTVVREMAKAAADGDREVRRAEKDTERETSRAAHNGERETRRAGQDVGRETVRAVKKI 387

  Fly   815 LKKCR 819
            .||.|
  Fly   388 GKKLR 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492
		STKc_LIMK	407..693	CDD:271056	85/298 (29%)
Takl1	NP_732554.1	S_TKc	15..262	CDD:214567	86/314 (27%)
Takl1	NP_732554.1	STKc_TAK1	17..274	CDD:270960	92/324 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445222
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930