DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and Map3k11

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001013168.1	Gene:	Map3k11 / 309168	RGDID:	1359261	Length:	850	Species:	Rattus norvegicus

Alignment Length:	815	Identity:	183/815 - (22%)
Similarity:	298/815 - (36%)	Gaps:	213/815 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 PQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEE----AQRNFIKEVAVLRL 452
            |..:....:|.:.|.:|.|.||||::.:.|  ||::.:|...:..:|    ...:..:|..:..:
  Rat   109 PCEVASFQELRLEEVIGIGGFGKVYRGSWR--GELVAVKAARQDPDEDISVTAESVRQEARLFAM 171

  Fly   453 LDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELI---HDPAQVLPWPQRVRLARDIACGMSYLH 514
            |.|.:::....|..::..|.:|.||.|||.|...:   ..|..||     |..|..||.||.|||
  Rat   172 LAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVL-----VNWAVQIARGMHYLH 231

  Fly   515 S---MNIIHRDLNSMNCLV--------REDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANS 568
            .   :.:|||||.|.|.|:        .|.:::.:.||||||.                   .:.
  Rat   232 CEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLARE-------------------WHK 277

  Fly   569 DAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEII-GRVEAD 632
            ...||.:||..                  |||||::|...:.:..||:|||::|.|:: |.|..
  Rat   278 TTQMSAAGTYA------------------WMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPY- 323

  Fly   633 PDFMPRNSD-----FSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADD 692
                 |..|     :.:...:......:.|||||.::...|...:|..||.|.::   ||:|
  Rat   324 -----RGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASI---LQQL--- 377

  Fly   693 LAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNL-DELVKSAVDSEISPVEKEKENMVI 756
                    |.|  |.:..:|....|..::....:|.:..| |||           ..|||| ::.
  Rat   378 --------EAL--EAQVLREMPRDSFHSMQEGWKREIQGLFDEL-----------RAKEKE-LLS 420

  Fly   757 KPQDIPKSPHLGKDFSPSGERLRDSMRARRRQRFLGAQEE----RRNLT----------PDTESK 807
            :.:::.::         :.|:...:.:.|||:..| ||.|    .|.||          |....:
  Rat   421 REEELTRA---------AREQRSQAEQLRRREHLL-AQWELEVFERELTLLLQQVDRERPHVRRR 475

  Fly   808 ERALKKALKKCRPFGER-------GYLVDLRAGAELQLEDVRDLNTYSDVDSSCDTSLNYHDVNN 865
            ....|::..:.|..|||       .:.:.::|...|.    |..|.:........|...:..:..
  Rat   476 RGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLD----RRRNVFEVGAGDSPTFPRFRAIQL 536

  Fly   866 LPAAQEDENTVKPGKEELLEESTN--------------KPSNQESQHHRLAIDDMRTRLNQCRSK 916
            .||  |...|........|::|:|              ||...::...|..:|:....|
  Rat   537 EPA--ESGQTWGRQSPRRLDDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYL------ 593

  Fly   917 FEHLEEASRRNFNQSQHSMKNFFKTPPVALKMFQRLEHEAAALNGGNNCPPPPPRTQRINQTPIF 981
                        :....|......|||              ||||....|.|.|...|.:.....
  Rat   594 ------------DSDDSSPLGSPSTPP--------------ALNGNPPRPSPEPEEPRRSGPTER 632

  Fly   982 GRKNPPVAIVGQKLQHAESLEDLASSGVAKQLATP---APKRSKATATTKGGQSSNPPLFLPPSL 1043
            |..:....::.:.|....:|  |||.|:.:.|..|   :.:|.::.......|.::|   .||.|
  Rat   633 GNSSGTPKLIQRALLRGTAL--LASLGLGRDLQPPGGLSRERGESPTAPPPAQMASP---CPPDL 692

  Fly  1044 NISVALNSNGNVTTTTNTNSSCPPSASDWLPKKHKLTLPLPSAQQQRTSSNHRLPMCNNKGKTLK 1108
                      ..|...:.:.:.|.:.....|....|.|.:.|.|....|....    ..:|:|:.
  Rat   693 ----------PSTPLIHLSQATPDARGPLTPAPLLLDLGVSSGQPSAKSPRRE----ETRGRTVS 743

  Fly  1109 PLP----SRTGSQGIPASNCVSPTRSSRPGSPTKH 1139
            |.|    |..|:.|.|.|..:......|| ||.::
  Rat   744 PPPGISRSAPGTPGTPRSPPLGLISRPRP-SPLRN 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492
		STKc_LIMK	407..693	CDD:271056	84/309 (27%)
Map3k11	NP_001013168.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..37
		SH3_MLK1-3	46..103	CDD:212992
		STKc_MLK3	114..380	CDD:271049	87/329 (26%)
		STYKc	118..377	CDD:214568	85/311 (27%)
		Leucine-zipper 1	404..425		8/32 (25%)
		Leucine-zipper 2	439..460		9/21 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..850		60/296 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910