DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and Raf1

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	XP_008761439.1	Gene:	Raf1 / 24703	RGDID:	3531	Length:	668	Species:	Rattus norvegicus

Alignment Length:	698	Identity:	155/698 - (22%)
Similarity:	247/698 - (35%)	Gaps:	208/698 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 YGKRSCQPADAKARITTAGKPMHSIRLVEIPKDATPGLRV-DGVALDDGCPTVRITDLFCNF-FL 210
            |.:|    |....::|.:.|..::|| |.:|......:.| :|::|.|           |.. .|
  Rat    38 YQRR----ASDDGKLTDSSKTSNTIR-VFLPNKQRTVVNVRNGMSLHD-----------CLMKAL 86

  Fly   211 WLTSMAEQCCGAPYRIDVNLTNLHIGDRI-LEVNGTPVS----DSSVEQIDKLIRSNEKMLQLTV 270
            .:..:..:|| |.:|    |...|.|.:. |:.|....|    :..|:.:|.:..:.....:.|.
  Rat    87 KVRGLQPECC-AVFR----LLQEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTF 146

  Fly   271 ---------------------------EHDPVQVCRSCSQADIQRAMSASTLILPLST------- 301
                                       ||...:|...|    :..:.....|:.|.||
  Rat   147 LKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMC----VDWSNIRQLLLFPNSTASDSGVP 207

  Fly   302 ------------SASSVEVGRERLYKT----------PGEQGTKARKLRQATN-----ASTTIPP 339
                        |.|.:....:..|.|          |..:|:.:::.|..:.     .|||:|.
  Rat   208 APPSFTMRRMRESVSRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPV 272

  Fly   340 AAGATAMTQLKEKERCSSLSKLLDEQHQAQQH--SAHPQLY-----DLSRT-------------- 383
            .:.......|....|..|....|..:...:.|  ||.|...     :||.|
  Rat   273 DSRMIENNSLNASPRACSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE 337

  Fly   384 --------QSCRVVQKPQR------IFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHR 434
                    :..::..:.||      ...|:::::..::|.|.||.|:|........|.:||.:..
  Rat   338 RAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDP 402

  Fly   435 ADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQR 499
            ..|:.|. |..||||||...|.::|.|:|.:.|| .|.:||::..|..|.:.:|.........|.
  Rat   403 TPEQLQA-FRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQL 465

  Fly   500 VRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGS 564
            :.:||..|.||.|||:.||||||:.|.|..:.|..:|.:.||||| :|.:
  Rat   466 IDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA-TVKS--------------- 514

  Fly   565 GANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPE---MMKGLKYDEKVDVFSFGIMLCEI- 625
                          |.|.|:|..|   ..|:..|||||   |.....:..:.||:|:||:|.|:
  Rat   515 --------------RWSGSQQVEQ---PTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELM 562

  Fly   626 ------------------IGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLN 672
                              :||..|.||.               .:....||:...::...|....
  Rat   563 TGELPYSHINNRDQIIFMVGRGYASPDL---------------SRLYKNCPKAMKRLVADCVKKV 612

  Fly   673 PDMRPCFETLHVWLQRLADDL-AADRVPPERLLHEIETFQEWYASSED 719
            .:.||.|..:...::.|...| ..:|...|..||..       |.:||
  Rat   613 KEERPLFPQILSSIELLQHSLPKINRSASEPSLHRA-------AHTED 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751	155/698 (22%)
		PDZ_signaling	172..271	CDD:238492	23/132 (17%)
		STKc_LIMK	407..693	CDD:271056	86/307 (28%)
Raf1	XP_008761439.1	RBD_CRAF	55..131	CDD:340655	21/92 (23%)
		C1_A_C-Raf	136..187	CDD:410420	5/54 (9%)
		STKc_C-Raf	356..638	CDD:271051	89/331 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000