DRSC/TRiP Functional Genomics Resources

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Protein Alignment LIMK1 and Tesk1

DIOPT Version :10

Sequence 1:NP_511139.2 Gene:LIMK1 / 32207 FlyBaseID:FBgn0283712 Length:1257 Species:Drosophila melanogaster
Sequence 2:NP_035701.3 Gene:Tesk1 / 21754 MGIID:1201675 Length:627 Species:Mus musculus


Alignment Length:767 Identity:208/767 - (27%)
Similarity:298/767 - (38%) Gaps:250/767 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   382 RTQSCRVVQKP-QRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIK 445
            |..|.|.::.. ..:.|..|....||:|.|||.:|:||.|||||:||||| :::.... :.|.::
Mouse    32 RPSSYRALRSAVSSLARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLK-MNKLPSN-RSNTLR 94

  Fly   446 EVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGM 510
            ||.::..|.|.::|:|:||.....:||.:|||:.||.|::|:..| :.|.||.|:.||.|||.|:
Mouse    95 EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSP-EPLSWPVRLHLALDIAQGL 158

  Fly   511 SYLHSMNIIHRDLNSMNCLV-REDR--SVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPM 572
            .|||:..:.||||.|.|||| ||||  :.:|.|||||..:                       |:
Mouse   159 RYLHAKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKI-----------------------PV 200

  Fly   573 SPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMP 637
            ...||        |::...|||:|||||||:::|..||||.|||:|||:|||:|.||.||||::|
Mouse   201 YREGT--------RKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLP 257

  Fly   638 RNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFE--TLHVWLQRLADDLAADRVPP 700
            |..||.|:...||......||.||:.:|..||.:.|..|..|.  |.|:                
Mouse   258 RTEDFGLDVPAFRTLVGNDCPLPFLLLAIHCCSMEPSTRAPFTEITQHL---------------- 306

  Fly   701 ERLLHEIETFQEWYASSEDALSPTSQRSLNNLDELVKSAVDSEISPVEK---EKENMVIKPQDIP 762
            |::|.:                                  ..|.:|:.|   .|..:......:|
Mouse   307 EQILEQ----------------------------------QPEATPLAKPPLTKAPLTYNQGSVP 337

  Fly   763 KSPHLGKDFSPSGERLRDSMRARRRQRFLGAQEERRNLTPDTESKERALKKALKKCRPFGERGYL 827
            :.       .||....|...|..|.:..|       .|.|..||.. :....|.:..||..|   
Mouse   338 RG-------GPSATLPRPDPRLSRSRSDL-------FLPPSPESPP-SWGDNLTRVNPFSLR--- 384

  Fly   828 VDLRAGAELQLEDV--RDLNTYSDVDSSCDTSLNYHDVNNLPAAQEDENTVKPGKEELLEESTNK 890
            .||| |.:::|.|.  :.......|..|..||      ..||.....:..|:|            
Mouse   385 EDLR-GGKIKLLDTPCKPATPLPLVPPSPLTS------TQLPLVTTPDILVQP------------ 430

  Fly   891 PSNQESQHHRLAIDDMRTRLNQCRSKFEHLEEASRRNFNQSQHSMKNFFKTPPVALKMFQRLEHE 955
                            .|.:.:|||.                          |.:.::.:|:|  
Mouse   431 ----------------ETPVRRCRSL--------------------------PSSPELPRRME-- 451

  Fly   956 AAALNGGNNCPPPPPRTQRINQTPIFGRKNPPVAIVGQKLQHAESLEDLASSGVAKQLATPAPKR 1020
             .||.|    |.|.|                        :...|...|...|       :|.|: 
Mouse   452 -TALPG----PGPSP------------------------MGPTEERMDCEGS-------SPEPE- 479

  Fly  1021 SKATATTKGGQSSNPPLFLPPSLNISVALNSNGNVTTTTNTNSSCPPSASDWLPKKHK------- 1078
                          || .|.|.|.::||         |.|..|:|..::..|.|:...       
Mouse   480 --------------PP-GLAPQLPLAVA---------TDNFISTCSSASQPWSPRSGPPLNNNPP 520

  Fly  1079 ---LTLPLPSAQQQRTSSNHRLPMCNNKGKT-LKPLPS--RTGSQGIPASNC 1124
               :..|...|::....:.|.||......:| ..|.||  |...:|:|...|
Mouse   521 AVVVNSPQGWAREPWNRAQHSLPRAAALERTEPSPPPSAPREPEEGLPCPGC 572

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LIMK1NP_511139.2 LIM1_LIMK 33..88 CDD:188750
LIM2_LIMK 95..148 CDD:188751
PDZ_LIMK-like 169..274 CDD:467236
STKc_LIMK 407..693 CDD:271056 122/290 (42%)
Tesk1NP_035701.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 1/3 (33%)
PKc_TESK 58..312 CDD:271057 124/303 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..373 14/71 (20%)
Required for interaction with YWHAB. /evidence=ECO:0000250|UniProtKB:Q63572 421..525 33/220 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 436..485 20/128 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 500..519 3/18 (17%)
Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000250|UniProtKB:Q63572 528..627 12/45 (27%)
Required for interaction with PARVA. /evidence=ECO:0000250|UniProtKB:Q63572 528..625 12/45 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..565 8/32 (25%)
Blue background indicates that the domain is not in the aligned region.

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