DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and Tesk2

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_596887.1	Gene:	Tesk2 / 170908	RGDID:	619984	Length:	570	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	165/547 - (30%)
Similarity:	253/547 - (46%)	Gaps:	125/547 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 EKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDK 469
            ||:|.|||.:||||.||.||:||.||....:...|  |.:||:.::..|.|.::|:|:||.....
  Rat    62 EKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRA--NLLKEMQLMNRLSHPNILRFMGVCVHQG 124

  Fly   470 KLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDR 534
            :||.:|||:..|.|::|: |....|||..||:||.|||.|:||||...|.||||.|.|||::.|.
  Rat   125 QLHALTEYINSGNLEQLL-DSNLYLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDE 188

  Fly   535 ---SVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNP 596
               |.:|||||||.     ::|..::     ||                       ::..|||:|
  Rat   189 NGYSAVVADFGLAE-----KIPDASI-----GS-----------------------EKLAVVGSP 220

  Fly   597 YWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPF 661
            :|||||:::...|:||.||||:||:|||||.|::||||::||..:|.|:...| :.....||..|
  Rat   221 FWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAF-QHMVGDCPSDF 284

  Fly   662 VKVAFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQ 726
            :::.|.||:::|.:||.||.:...|:.:...|..:.:..:|                 .|.||::
  Rat   285 LQLTFNCCNMDPKLRPSFEEIGKTLEEIMSRLQEEELERDR-----------------KLQPTAK 332

  Fly   727 ---------RSLNNLDELVKSAVDSEISPVEKEKENMVIKPQDIPKSPHLGKDFSPSGERLRDSM 782
                     :.|::||:                            |.||.    ||   |.|.::
  Rat   333 GLLEKVPGGKRLSSLDD----------------------------KIPHK----SP---RPRRTI 362

  Fly   783 RARRRQRFLGAQEERRN---LTPDTESKERALKKALKKCRPFGERGYLVDLRAGAELQLEDVRDL 844
            ...|.|..:.:::..|.   |.|..:.::.|..  ..|..||..|   .||: |.:::..|:...
  Rat   363 WLSRSQSDIFSRKPPRTVNVLDPYYQPRDGATH--TPKVNPFSAR---QDLK-GGKVKFFDLPSK 421

  Fly   845 NTYS---DVDSSCDTSLNYHDVNNLPAAQEDENTVKPGKEELLEE-----------STNKPSNQE 895
            :..|   |:|:....:::..|.....|.........||..|.|.:           |...|....
  Rat   422 SVISLVFDLDAPGPGTVSLADCQEPLAPSSRRWRSLPGSPEFLHQACPFVGCEESLSDGPPPRLS 486

  Fly   896 SQHHRL-AIDDMRTRLNQCRSKFEHLE 921
            |..:|: .|...||......|..|.::
  Rat   487 SLKYRVREIPPFRTSALSATSAHEAMD 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492
		STKc_LIMK	407..693	CDD:271056	116/288 (40%)
Tesk2	NP_596887.1	PKc_TESK	64..316	CDD:271057	116/288 (40%)
Tesk2	NP_596887.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..570		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920