DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and Limk2

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	XP_030101468.1	Gene:	Limk2 / 16886	MGIID:	1197517	Length:	702	Species:	Mus musculus

Alignment Length:	704	Identity:	281/704 - (39%)
Similarity:	396/704 - (56%)	Gaps:	115/704 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VSGGHSPLCAHCRGQLLPHPEEPIVMALGQQWHCDCFRCSVCEGHLHNWYFEREGLLYCREDYYG 89
            :.|..:..|..| |..:|..:. :.....:.||..|||||.|:..|.|||:|::|.|||.:||:.
Mouse    62 LKGDEAWRCRGC-GTYVPLSQR-LYRTANEAWHGSCFRCSECQESLTNWYYEKDGKLYCHKDYWA 124

  Fly    90 RFGDACQQCMAVITGPVMVAGEHKFHPECFCCTACGSFIGEGESYALVERSKLYCGQCYGKRSCQ 154
            :||:.|..|..::|||.|||||.|:|||||.|.:|...|.:|::||||:.:.||||:|:.:....
Mouse   125 KFGEFCHGCSLLMTGPAMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLA 189

  Fly   155 PADAKARITTAGKPM-HSIRLVEIPKDATPGLR------VDGVALDDGCPTVRITDLFCNFFLWL 212
            |...:....:....: :|:.|:.:|  ||...|      |:. |..:...||::.::
Mouse   190 PMFERLSTESVQDQLPYSVTLISMP--ATTECRRGFSVTVES-ASSNYATTVQVKEV-------- 243

  Fly   213 TSMAEQCCGAPYRIDVNLTN---LHIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLTVEHDP 274
                       .|:.::..|   :|.||||||:|||||....||:::..|:...:.|||.:||||
Mouse   244 -----------NRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAIKQTSQTLQLLIEHDP 297

  Fly   275 V--QVCRSCSQADIQRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGT-KARKLRQATNASTT 336
            |  ::.:....|.:...|.::...|.|||           |.....::|| :.|.||::.:.|.:
Mouse   298 VPQRLDQLRLDARLPPHMQSTGHTLMLST-----------LDTKENQEGTLRRRSLRRSNSISKS 351

  Fly   337 IPPAAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQK-PQRIFRATD 400
            ..|::....:.          ||:                  |:||::|.|.... .|:|||..|
Mouse   352 PGPSSPKEPLL----------LSR------------------DISRSESLRCSSSYSQQIFRPCD 388

  Fly   401 LVIGEKLGEGFFGKVFK------VTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVL 459
            |:.||.||:||||:..|      |||:.:|:|||:|||.|.|||.|:.|:.||.|:|.|||.:||
Mouse   389 LIHGEVLGKGFFGQAIKSWEGGQVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVL 453

  Fly   460 KFIGVLYKDKKLHMVTEYVAGGCLKELIH--DPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRD 522
            ||||||||||||:::|||:.||.||:.:.  ||   .||.|:||.|:.|:.||:|||||.|||||
Mouse   454 KFIGVLYKDKKLNLLTEYIEGGTLKDFLRSVDP---FPWQQKVRFAKGISSGMAYLHSMCIIHRD 515

  Fly   523 LNSMNCLVREDRSVIVADFGLARSV--DAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQ 585
            |||.|||::.|::|:||||||:|.:  :..|.|....|              :...|||:|   .
Mouse   516 LNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPVEKAT--------------TKKRTLRKS---D 563

  Fly   586 RRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFR 650
            |::|||||||||||||||:.|..|||.||||||||:||||||:|.||||.:||..||.||.:.|.
Mouse   564 RKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFW 628

  Fly   651 EKFC-AQCPEPFVKVAFVCCDLNPDMRPC-------FETLHVWLQRLADDLAAD 696
            |||. ..||..|..:|.:||.|.|:.||.       ||.|.::|..||..|.|:
Mouse   629 EKFVPTDCPPAFFPLAAICCKLEPESRPAFSKLEDSFEALSLFLGELAIPLPAE 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	22/54 (41%)
		LIM2_LIMK	95..148	CDD:188751	28/52 (54%)
		PDZ_signaling	172..271	CDD:238492	29/107 (27%)
		STKc_LIMK	407..693	CDD:271056	159/303 (52%)
Limk2	XP_030101468.1	LIM	70..123	CDD:351770	22/54 (41%)
		LIM2_LIMK2	125..183	CDD:188849	30/57 (53%)
		PDZ	210..294	CDD:366185	29/105 (28%)
		STKc_LIMK2	395..672	CDD:271124	156/296 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E33208_3BEDK
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1222
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	1	1.000	-	-		FOG0003618
OrthoInspector	1	1.000	-	-		otm43547
orthoMCL	1	0.900	-	-		OOG6_103981
Panther	1	1.100	-	-	LDO	PTHR46485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2495
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830