DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and Limk1

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	XP_036020724.1	Gene:	Limk1 / 16885	MGIID:	104572	Length:	702	Species:	Mus musculus

Alignment Length:	765	Identity:	309/765 - (40%)
Similarity:	409/765 - (53%)	Gaps:	159/765 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GGHSPLCAHCRGQLLPHPEEPIVMALGQQWHCDCFRCSVCEGHLHNWYFEREGLLYCREDYYGRF 91
            |...|:||.| ||.:  .:...:.||...||.|||||..|...|.:.|:|::|.|:|::||:.|:
Mouse    19 GSELPVCASC-GQRI--YDGQYLQALNADWHADCFRCCECSVSLSHQYYEKDGQLFCKKDYWARY 80

  Fly    92 GDACQQCMAVIT-GPVMVAGEHKFHPECFCCTACGSFIGEGESYALVERSKLYCGQCYGKRSCQP 155
            |::|..|...|| |.||||||.|:|||||.|.|||:|||:|::|.|||.|||||||||.:....|
Mouse    81 GESCHGCSEHITKGLVMVAGELKYHPECFICLACGNFIGDGDTYTLVEHSKLYCGQCYYQTVVTP 145

  Fly   156 ADAKARITTAGKPM-HSIRLVEIPKDATPGLRVDGVALD-----DGC-----PTVRITDLFCNFF 209
            ...:....:.|..: |::.||.||..| .|.|...|::|     .||     .|||:..:
Mouse   146 VIEQILPDSPGSHLPHTVTLVSIPASA-HGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGV----- 204

  Fly   210 LWLTSMAEQCCGAPYRIDVNLTNLHIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLTVEHDP 274
                   :..|.:|   ||. .::|:||||||:||||:.:..:::||.||:...::||||:||||
Mouse   205 -------DPGCMSP---DVK-NSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDP 258

  Fly   275 VQVCRSCSQADIQRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGTKARKLRQATNASTTIPP 339
            ..   |.....:.   ..|.|..|:.|.:              |:..:.||:.....:.|....|
Mouse   259 HD---SLGHGPVS---DPSPLSSPVHTPS--------------GQAASSARQKPVLRSCSIDTSP 303

  Fly   340 AAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQKPQRIFRATDLVIG 404
            ...:.|                          |...|..||.|::|.|||.:|.||||.:||:.|
Mouse   304 GTSSLA--------------------------SPASQRKDLGRSESLRVVCRPHRIFRPSDLIHG 342

  Fly   405 EKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDK 469
            |.||:|.||:..|||||::|||||:|||.|.|||.||.|:|||.|:|.|:|.:||||||||||||
Mouse   343 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDK 407

  Fly   470 KLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVRE-- 532
            :|:.:|||:.||.|:.:|.:.....||.|||..|:|||.||:||||||||||||||.||||||
Mouse   408 RLNFITEYIKGGTLRGIIKNMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVREPS 472

  Fly   533 -----------------------------------------------------DRSVIVADFGLA 544
                                                                 :|:|:|||||||
Mouse   473 QTPPEVAQATQAAATTATVCGQGHLGRLLELETWQRHVRGGQEDKRQSAPSLQNRNVVVADFGLA 537

  Fly   545 R-SVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLK 608
            | .:|                      ..:.|..||..|...|::|||||||||||||||:.|..
Mouse   538 RLMID----------------------EKNQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRS 580

  Fly   609 YDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFC-AQCPEPFVKVAFVCCDLN 672
            ||||||||||||:||||||||.||||::||..||.||.:.|.:::| ..||..|..:...||||:
Mouse   581 YDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLD 645

  Fly   673 PDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIET-FQEWYASSEDAL 721
            |:.||.|..|..||:.|...|:. .:|....|.::|. |.|.|...|.:|
Mouse   646 PEKRPSFVKLEQWLETLRMHLSG-HLPLGPQLEQLERGFWETYRRGESSL 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	22/54 (41%)
		LIM2_LIMK	95..148	CDD:188751	36/53 (68%)
		PDZ_signaling	172..271	CDD:238492	37/108 (34%)
		STKc_LIMK	407..693	CDD:271056	162/342 (47%)
Limk1	XP_036020724.1	LIM1_LIMK1	5..77	CDD:188846	24/60 (40%)
		LIM2_LIMK1	84..138	CDD:188848	36/53 (68%)
		PDZ	165..255	CDD:395476	37/106 (35%)
		STKc_LIMK1	345..666	CDD:271123	162/342 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E33208_3BEDK
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1738
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1222
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	1	1.000	-	-		FOG0003618
OrthoInspector	1	1.000	-	-		otm43547
orthoMCL	1	0.900	-	-		OOG6_103981
Panther	1	1.100	-	-	O	PTHR46485
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5000
SonicParanoid	1	1.000	-	-		X2495
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.860