DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and Braf

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	XP_038964558.1	Gene:	Braf / 114486	RGDID:	619908	Length:	847	Species:	Rattus norvegicus

Alignment Length:	686	Identity:	150/686 - (21%)
Similarity:	247/686 - (36%)	Gaps:	208/686 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 HNW----YFEREGLLYCREDYYGRFGDACQQCMAVITGPVMVAGEHKFHPEC-----FCCTACGS 126
            ||:    :|......:||:..:..|  .||.|            .:|||..|     ..|.....
  Rat   254 HNFVRKTFFTLAFCDFCRKLLFQGF--RCQTC------------GYKFHQRCSTEVPLMCVNYDQ 304

  Fly   127 ----FIGEGESYALVERSKLYCGQC---YGKRSCQPADA-KARITTAGKPMHSIRLVEIPKDATP 183
                |:.:...:..|.:.:.:..:.   .|..|..|:|: ..:|.|:..|..||   .||:...|
  Rat   305 LDLLFVSKFFEHHPVPQEEAFSAETTLPSGCSSAPPSDSIGPQILTSPSPSKSI---PIPQPFRP 366

  Fly   184 ---------GLRVDGVALDDGCPTVRITDLFCNFFLWLTSMAEQCCGAPYRIDVNLTNLHIGDR- 238
                     |.|    ......|.|.|..:                 .|..||.....:.:.|:
  Rat   367 ADEDHRNQFGQR----DRSSSAPNVHINTI-----------------EPVNIDEKFPEVELQDQR 410

  Fly   239 -ILEVNGTPVSDSSVEQIDKLIRSNEKML----------QLTVEHDPVQVCRSCSQADIQRAMSA 292
             ::...|.....:.:.|:.:.:|..:...          ::..:.:|..|.|..:     ..:||
  Rat   411 DLIRDQGFRGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFRGST-----TGLSA 470

  Fly   293 STLILPLSTSASSVEVGRERLYKTPGEQGTKARKLRQATNASTTIPPAAGATAMTQLKEKERCSS 357
            :.   |.|...|...|  :.|.|:||.|    |:.:.::::|:|             :::.|..:
  Rat   471 TP---PASLPGSLTNV--KALQKSPGPQ----RERKSSSSSSST-------------EDRSRMKT 513

  Fly   358 LSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQKPQRIFRATDLVIGEKLGEGFFGKVFKVTHRQ 422
            |.:        :..|...::.|                   ..:.:|:::|.|.||.|:|  .:.
  Rat   514 LGR--------RDSSDDWEIPD-------------------GQITVGQRIGSGSFGTVYK--GKW 549

  Fly   423 SGEVMVLKELHRADEEAQ--RNFIKEVAVLRLLDHRHVLKFIGVLYKDK-KLHMVTEYVAGGCLK 484
            .|:|.| |.|:......|  :.|..||.|||...|.::|.|:|  |..| :|.:||::..|..|.
  Rat   550 HGDVAV-KMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG--YSTKPQLAIVTQWCEGSSLY 611

  Fly   485 ELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDA 549
            ..:|.........:.:.:||..|.||.|||:.:||||||.|.|..:.||.:|.:.|||||
  Rat   612 HHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLA----- 671

  Fly   550 PRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPE---MMKGLKYDE 611
                    |.....||::....:|                    |:..|||||   |.....|..
  Rat   672 --------TVKSRWSGSHQFEQLS--------------------GSILWMAPEVIRMQDKNPYSF 708

  Fly   612 KVDVFSFGIMLCEI-------------------IGRVEADPDFMPRNSDFSLNQQEFREKFCAQC 657
            :.||::|||:|.|:                   :||....||.               .|..:.|
  Rat   709 QSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDL---------------SKVRSNC 758

  Fly   658 PEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDL 693
            |:...::...|.....|.||.|..:...::.||..|
  Rat   759 PKAMKRLMAECLKKKRDERPLFPQILASIELLARSL 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	5/20 (25%)
		LIM2_LIMK	95..148	CDD:188751	10/64 (16%)
		PDZ_signaling	172..271	CDD:238492	16/119 (13%)
		STKc_LIMK	407..693	CDD:271056	87/310 (28%)
Braf	XP_038964558.1	RBD_BRAF	170..251	CDD:340654
		C1_B-Raf	249..308	CDD:410421	14/67 (21%)
		STKc_Raf	536..788	CDD:270964	85/304 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000