Protein Alignment LIMK1 and limk1b

DIOPT Version :10

• Sequence 1: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Sequence 2: XP_005161503.1
• Gene: limk1b / 101883214
• ZFINID: ZDB-GENE-110411-106
• Length: 615
• Species: Danio rerio
• Alignment Length: 669
• Identity: 270/669 - (40%)
• Similarity: 368/669 - (55%)
• Gaps: 111/669 - (16%)

  Fly    62 RCSVCEGHLHNWYFEREGLLYCREDYYGRFGDACQQCM-AVITGPVMVAGEHKFHPECFCCTACG 125
            ||..|...|.:||:||:|..:|::.|..||.:.|..|. ::.|||:||||::|:|||||.|.:|.
Zfish    17 RCCECNSVLADWYYERDGQFFCKKHYLSRFAEQCYGCTESINTGPIMVAGKNKYHPECFLCESCD 81

  Fly   126 SFIGEGESYALVERSKLYCGQC-YGKRSCQPADAKARITTAGKPM-HSIRLVEIPKDA--TPGLR 186
            .|||:|:|:|||:.:.|||||| |.|.|.|...||      |.|: |.:..:..|..|  ..||.
Zfish    82 VFIGDGDSFALVDYTNLYCGQCHYQKVSTQHLAAK------GSPLPHMVTSMSFPPSAESRQGLF 140

  Fly   187 VDGVALD-DGCPTVRITDLFCNFFLWLTSMAEQCCGAPYRIDVNLTN-----LHIGDRILEVNGT 245
            ......| :...||...||.                       ||:.     :|:||||||:||.
Zfish   141 FTVEKKDKEHLVTVSQLDLH-----------------------NLSAEVKPLIHVGDRILEINGI 182

  Fly   246 PVSDSSVEQIDKLIRSNEKMLQLTVEHDPVQVCRSCSQADIQRAMSASTLILPLSTSASSVEVGR 310
            .|.:..:.:|:.:|...|..||:|:||:|..   ...|.|:                  |..:|.
Zfish   183 SVHNIPLNEINLVIHDTEHWLQITIEHNPKD---HIKQEDL------------------SGLLGE 226

  Fly   311 ERLYKTPGEQG-TKARKLRQATNASTTIPPAAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSA- 373
            |  ...||..| ......||.::.|..|              ...||     :|:....|:|:|
Zfish   227 E--LDQPGNLGFFPLPNNRQISHRSKNI--------------LRSCS-----IDKVPCLQRHAAL 270

  Fly   374 --HPQLYDLSRTQSCR--VVQKPQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHR 434
              |.:  |::|::|.|  ...|.|||||.:||:.||.||:|.||:..||||.::|||||:|||.:
Zfish   271 LSHRR--DINRSESLRFDANDKTQRIFRPSDLIYGEILGKGCFGQAIKVTHLETGEVMVIKELLQ 333

  Fly   435 ADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQR 499
            .|||.|:.|:|||.|:|.|:|.:||||||:|||||:|::::|||.||.|::.|...|...||..|
Zfish   334 FDEETQKTFLKEVKVMRCLEHPNVLKFIGILYKDKRLNLISEYVQGGTLRDTILKMASDHPWNLR 398

  Fly   500 VRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGS 564
            |..|:|||.||:||||||:|||||||.||.|||:::|:|||||||:.|
Zfish   399 VSYAKDIAAGMAYLHSMNVIHRDLNSHNCFVRENQTVVVADFGLAQLV----------------- 446

  Fly   565 GANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRV 629
               .|...|..|.:.:.....|::|||||||||||||||:.|..|||:||:|||||:||||||||
Zfish   447 ---KDEKTSSPGQMSKLNKLGRKKRYTVVGNPYWMAPEMINGKIYDERVDIFSFGIVLCEIIGRV 508

  Fly   630 EADPDFMPRNSDFSLNQQEFREK-FCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDL 693
            .|||||:||..::.||.:||.|: :...||..|..:|.:||.|..:.||.|..|..||:.:...|
Zfish   509 YADPDFLPRTQEYGLNVKEFLERCWSKDCPAAFFPIAVLCCALEAEKRPVFAKLEEWLENVMMHL 573

  Fly   694 AADRVPPERLLHEIETFQE 712
            .........||...::|.|
Zfish   574 EMGLPLMSELLKVRQSFWE 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	10/25 (40%)
		LIM2_LIMK	95..148	CDD:188751	31/54 (57%)
		PDZ_LIMK-like	169..274	CDD:467236	30/113 (27%)
		STKc_LIMK	407..693	CDD:271056	149/286 (52%)
limk1b	XP_005161503.1	LIM	<17..42	CDD:413332	10/24 (42%)
		LIM2_LIMK	50..104	CDD:188751	30/53 (57%)
		PDZ_LIMK-like	121..211	CDD:467236	30/112 (27%)
		Protein Kinases, catalytic domain	306..573	CDD:473864	149/286 (52%)