DRSC/TRiP Functional Genomics Resources

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Protein Alignment LIMK1 and FPGT-TNNI3K

DIOPT Version :9

Sequence 1:NP_511139.2 Gene:LIMK1 / 32207 FlyBaseID:FBgn0283712 Length:1257 Species:Drosophila melanogaster
Sequence 2:NP_001106279.3 Gene:FPGT-TNNI3K / 100526835 HGNCID:42952 Length:936 Species:Homo sapiens


Alignment Length:623 Identity:146/623 - (23%)
Similarity:229/623 - (36%) Gaps:194/623 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 DVNLTNLHIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLTV----EHDPVQVCRSCSQADIQ 287
            |||::. .:|||.|.:    .|......|.||:........:..    :|.|:..|......||.
Human   293 DVNVSG-EVGDRPLHL----ASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIV 352

  Fly   288 RAMSASTL-------------ILPLSTSASSVEVGRERLYKTPGEQGTKARKLRQATNASTTIPP 339
            :.:..|.|             .|.|:......||.:|.:..:..|..||          ......
Human   353 KYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK----------ENIFSE 407

  Fly   340 AAGATAMTQLKEKERCSSLSKLLDEQ------HQAQQ-----HSA----HPQLY----------- 378
            .|..:|.|..|..:    |.|.|.:|      ||.:.     |||    |.:|.           
Human   408 TAFHSACTYGKSID----LVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 468

  Fly   379 ----DLSRT------QSC----------------RVVQKPQ------------------------ 393
                |.||:      |:|                :..::||                        
Human   469 LVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPL 533

  Fly   394 -------------RIFRA----------TDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRA 435
                         .:.||          :::...|.:|.|.||||:|  .|...:::.:|. :||
Human   534 GKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYK--GRCRNKIVAIKR-YRA 595

  Fly   436 DEEAQRN----FIKEVAVLRLLDHRHVLKFIGVLYKD-KKLHMVTEYVAGGCLKELIHDPAQVLP 495
            :....::    |.:||::|..|:|..|::|:|....| .:..:||:|::||.|..|:|:..::|.
Human   596 NTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILD 660

  Fly   496 WPQRVRLARDIACGMSYLHSMN--IIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMT 558
            ...::.:|.|:|.||.|||::.  ||||||||.|.|:.||...:|||||.:|.:.:  |...|||
Human   661 LQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQS--LDEDNMT 723

  Fly   559 PGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMM-KGLKYDEKVDVFSFGIML 622
                         ..|                   ||..|||||:. :..:|..|.||||:.:.|
Human   724 -------------KQP-------------------GNLRWMAPEVFTQCTRYTIKADVFSYALCL 756

  Fly   623 CEIIGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQ 687
            .||:..........|..:...:.....|.......|:|...:.....:..|:.||.|..:.:.| 
Human   757 WEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKL- 820

  Fly   688 RLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTS 725
                         |..|..||......::|..:|||:|
Human   821 -------------EECLCNIELMSPASSNSSGSLSPSS 845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LIMK1NP_511139.2 LIM1_LIMK 33..88 CDD:188750
LIM2_LIMK 95..148 CDD:188751
PDZ_signaling 172..271 CDD:238492 11/47 (23%)
STKc_LIMK 407..693 CDD:271056 86/293 (29%)
FPGT-TNNI3KNP_001106279.3 ANK repeat 167..199 CDD:293786
Ank_2 172..265 CDD:403870
ANK repeat 201..232 CDD:293786
PHA03095 221..>515 CDD:222980 48/240 (20%)
ANK repeat 235..265 CDD:293786
ANK repeat 267..298 CDD:293786 3/4 (75%)
ANK repeat 300..333 CDD:293786 8/36 (22%)
ANK repeat 335..363 CDD:293786 7/27 (26%)
ANK repeat 370..403 CDD:293786 8/42 (19%)
ANK repeat 405..438 CDD:293786 9/36 (25%)
ANK repeat 440..470 CDD:293786 5/29 (17%)
PKc_TNNI3K 570..823 CDD:270966 87/303 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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