DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and map3k10

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	XP_002938858.3	Gene:	map3k10 / 100488058	XenbaseID:	XB-GENE-920944	Length:	990	Species:	Xenopus tropicalis

Alignment Length:	929	Identity:	209/929 - (22%)
Similarity:	361/929 - (38%)	Gaps:	212/929 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 DLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEE---AQRNFIKEVAVLRLLDHRHVLKF 461
            :|.:.|.:|.|.||||:|...| ..||.|....|..||:   ...|..:|..:..:|.|.:::..
Frog   118 ELNLEEIIGVGGFGKVYKGLWR-GDEVAVKAVRHDPDEDINVTAENVRQEAKLFCMLCHPNIIAL 181

  Fly   462 IGVLYKDKKLHMVTEYVAGGCLKELIHD---PAQVLPWPQRVRLARDIACGMSYLHS---MNIIH 520
            .||..|...|.:|.||..||.|...:..   ||.||     |..|..||.||:|||:   :.|||
Frog   182 KGVCLKPPHLCLVMEYARGGPLHRALAGKKVPAHVL-----VNWAVQIARGMNYLHNEAIVPIIH 241

  Fly   521 RDLNSMNCLVRE--------DRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGT 577
            |||.|.|.|:.|        ::::.:.||||||
Frog   242 RDLKSSNILILEKVEHDDLFNKTLKITDFGLAR-------------------------------- 274

  Fly   578 LRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEII-GRVEADPDFMPRNSD 641
                 ..|:..:.:..|...|||||:::...:.:..||:|||::|.|:: |.|..      |..|
Frog   275 -----EWQKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPY------REID 328

  Fly   642 -----FSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLA----------- 690
                 :.:...:......:.||||||::...|.|.:|..||.|..:   |::|.
Frog   329 ALAVAYGVAMNKLTLPIPSTCPEPFVRILEACWDPDPHSRPSFSCI---LEQLTTIEQSAMFQMP 390

  Fly   691 ----DDLAAD-RVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNLDELVK----SAVDSEISP 746
                ..|..| |:..:::..|:.|.::...|.|:.|...::.. ..|:|::|    ...:.||..
Frog   391 LESFHSLQEDWRLEIQQMFDELRTKEKELRSREEELVRAAEEQ-RILEEMLKRREQELAEREIDI 454

  Fly   747 VEKEKENMVIKP--QDIPKSPHLGKDFSPSGERLRDSMRARRRQRFLGAQEERRNLTPDTESKER 809
            ||:|. |:::..  |:.||......:|..|..:|:|..|......|      ...:|...
Frog   455 VEREL-NIIMYQMYQEKPKVKKRKGNFKKSRLKLKDGNRISLPSGF------EHKITVQA----- 507

  Fly   810 ALKKALKKCRPFGERGYLVDLRAGAELQLEDVRDLNTYSDVDSS----CDTSLNYHDVNNL---- 866
              ...|.||:..|...|   ...|:.|.:..:|.:. .:.||.|    ..:.|...:||..
Frog   508 --SPTLDKCKGQGSSSY---SPPGSPLIIPRLRAIR-LTPVDGSKTWGRSSVLKKDEVNTSNKKK 566

  Fly   867 -----PAAQEDENTVKPGKEELLEE--------STNKPSNQESQHHRLAIDDMRTRLNQCRSKFE 918
                 |::.:.:.  :.|.||.|:.        |::.|:..:|..|        |.::...:...
Frog   567 GRTWGPSSTQQKE--RAGGEERLKTLGEGSKQWSSSAPNLGKSPKH--------TPISVGFASLT 621

  Fly   919 HLEEASRRNFN--QSQHSMKNFFKTPPVALKMFQRLEHEAAALNGGNNCPPPPPRTQRINQTPIF 981
            .:||.:..:.:  ||.:|.:::. |.|....:....|..:.|....::.|....:::|.::..:.
Frog   622 EMEEYADADGSVPQSPYSAQSYL-TLPAQSDLRNHPEDTSQAAAPSSDSPKRGSQSRRKSELVLL 685

  Fly   982 GRKNPPVAI-VGQKLQHAESLEDLASSGVAKQLATPAPKRSKATATTKGGQSSNPPLFLPPSLNI 1045
            |..:...|: :|..|......|: ...|:. |.|...|:|  .|::.....|......:|.|
Frog   686 GCASLLAAVALGSDLSEMVPQEE-KRKGIF-QWAGRGPRR--RTSSPSRPMSYGEESVIPSS--- 743

  Fly  1046 SVALNSNGNVTTTTNTNSSCPPSASDWLPKKHKLTLPLPS-------------AQQQRTSSNHRL 1097
            ||.|.|..:::...:|.|.....:.|         :.|.|             .||....:|
Frog   744 SVTLISLSSISDCNSTRSLIRSDSDD---------IGLDSDTMSTGRVVKEDRGQQPNVGTN--- 796

  Fly  1098 PMCNNKGKTLK--PLPSRTGSQGIPASNCVSPTRSSRPGSPTKHLAQRHTAATAQRLTNAAATHQ 1160
            |:.:.|.::.|  |..|.|.:......|..:.||..| .:|:....::.|....:..::.:|..|
Frog   797 PLVDYKVESFKRDPKQSLTPTHVTAGRNNTNETRGHR-RTPSDGAIRQVTQGHKRSPSDGSAPFQ 860

  Fly  1161 -QQHQQQSSKTTRL---NILSPEKVHRLGA--------------RLTDQKQKM--------REEA 1199
             :...::.|...||   :.:.|..|.|...              |.:..:.:|        .:..
Frog   861 CEPGSKEPSPFPRLPDPHFVFPPPVRRKDTGVERPTSLEFAPRPRPSSSRPRMDPWKFVSLSQTH 925

  Fly  1200 AATASSVGGAGCAAGTAAG 1218
            :::.||.||..|::|:|.|
Frog   926 SSSPSSGGGDACSSGSAEG 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492
		STKc_LIMK	407..693	CDD:271056	89/323 (28%)
map3k10	XP_002938858.3	SH3_MLK1-3	37..94	CDD:212992
map3k10	XP_002938858.3	STKc_MLK2	124..381	CDD:271050	89/308 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910