Protein Alignment LIMK1 and limk2

DIOPT Version :9

• Sequence 1: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Sequence 2: NP_001135686.1
• Gene: limk2 / 100216249
• XenbaseID: XB-GENE-976145
• Length: 606
• Species: Xenopus tropicalis
• Alignment Length: 646
• Identity: 255/646 - (39%)
• Similarity: 353/646 - (54%)
• Gaps: 107/646 - (16%)

  Fly    93 DACQQCMAVITGPVMVAGEHKFHPECFCCTACGSFIGEGESYALVERSKLYCGQCYGKRSCQPAD 157
            :.|..|...:|||.||...:|||||||.|:.|.:.||||||::||:.:.||||.|......||..
 Frog    60 EQCLSCSLRLTGPAMVVSHYKFHPECFSCSGCKAMIGEGESFSLVQGTALYCGPCQKLLLLQPKF 124

  Fly   158 AKARITTAGK-PMHSIRLVEIPKDATPGLRVDGVALDDGCPTVRITDLFCNFFLWLTSMAEQCCG 221
            ....|.:|.: ..|.:.|:.:|..| .|.|...|:.::               :.:|.::.:
 Frog   125 EGLCIESAQEHDPHMLTLLRLPPQA-GGNRGFSVSREN---------------MQVTQVSTE--- 170

  Fly   222 APYRIDVNLTNLHIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLTVEHDPVQVCRSCSQADI 286
                   ||..||.||||||:||:||:..|.::.|.|:.|.::.|||.:||:|.      ....:
 Frog   171 -------NLNLLHQGDRILEINGSPVTTLSSKEADDLLCSTDRTLQLLIEHNPP------PNLPV 222

  Fly   287 QRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGTKARKLRQATNASTTIPPAAGATAMTQLKE 351
            ..|.       |.|.|..|:|.       ....:|...|...:.:|::|..|...
 Frog   223 DNAP-------PKSPSFRSIEA-------RGSTEGPMKRSSIRRSNSNTRSPGTC---------- 263

  Fly   352 KERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRV-VQKPQRIFRATDLVIGEKLGEGFFGKV 415
               |..                .|:  .:||::|.|. |...|:|||..:|:.||:||:||||:.
 Frog   264 ---CPK----------------DPR--SVSRSESLRCGVGGAQQIFRPCELLHGEELGKGFFGRA 307

  Fly   416 FKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAG 480
            .|||||.:|.|||:|||.:.||:.|:||:.||.|:|.|||.:||:||||||||.:|:::||::..
 Frog   308 IKVTHRATGRVMVMKELIQFDEQTQKNFLTEVKVMRSLDHPNVLRFIGVLYKDGRLNLLTEFIEC 372

  Fly   481 GCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLAR 545
            |.||:.:.  |...||.|:|..|:||||||:|||||:||||||||.|||::.|.:.:||||||:|
 Frog   373 GTLKDYLR--ADYCPWQQKVSFAKDIACGMAYLHSMSIIHRDLNSHNCLIKLDGTTVVADFGLSR 435

  Fly   546 -SVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKY 609
             .|:...||:             .|.|.:...|||::   .|::|||||||||||||||:.|..|
 Frog   436 LIVEEKPLPA-------------PDRPPTKKRTLRKN---NRKKRYTVVGNPYWMAPEMLNGKDY 484

  Fly   610 DEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFCAQ-CPEPFVKVAFVCCDLNP 673
            |||||:|||||:||||||:|.||||.:||..||.||.:.|.|||..: ||..|..:|..||.|.|
 Frog   485 DEKVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVRLFWEKFVPKDCPPGFFPLATSCCHLEP 549

  Fly   674 DMRPCFETLHVWLQRLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNLDE 734
            |.||.|..||..|..|:..:....:|   |..|:| :.|.....|..|:    |..:.|:|
 Frog   550 DQRPDFPHLHDALTALSLFVGELGIP---LPSELE-YMEHSLQLEYGLN----REFSKLEE 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751	28/52 (54%)
		PDZ_signaling	172..271	CDD:238492	28/98 (29%)
		STKc_LIMK	407..693	CDD:271056	155/287 (54%)
limk2	NP_001135686.1	LIM2_LIMK	62..115	CDD:188751	28/52 (54%)
		STYKc	296..562	CDD:214568	155/283 (55%)
		STKc_LIMK2	299..568	CDD:271124	155/286 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	309	1.000	Domainoid score	I1325
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	1	1.000	-	-		FOG0003618
OrthoInspector	1	1.000	-	-		otm48706
Panther	1	1.100	-	-	LDO	PTHR46485
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2495
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.110