DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LIMK1 and abl1

DIOPT Version :9

Sequence 1:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	XP_005172104.1	Gene:	abl1 / 100000720	ZFINID:	ZDB-GENE-100812-9	Length:	1081	Species:	Danio rerio

Alignment Length:	1028	Identity:	213/1028 - (20%)
Similarity:	380/1028 - (36%)	Gaps:	235/1028 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 HDPVQVCRSCSQADIQRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGTKAR--------KLR 328
            |.||.  |:.::..:...::.|.|:....:|              ||::....|        ::.
Zfish   143 HGPVS--RNAAEYLLSSGINGSFLVRESESS--------------PGQRSISLRYEGRVYHYRIN 191

  Fly   329 QATNASTTIPPAAGATAMTQLKEKERCSSLSK-LLDEQHQAQQHSAHPQLYDLSRTQSCRVVQKP 392
            .|::....:...:....:.:|....  |::|. |:...|........|.:|.:|.......:::
Zfish   192 TASDGKLYVSSESRFNTLAELVHHH--STVSDGLITTLHYPAPKRNKPTIYGVSPNYDKWEMER- 253

  Fly   393 QRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRH 457
                  ||:.:..|||.|.:|:|::...::....:.:|.| :.|......|:||.||::.:.|.:
Zfish   254 ------TDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL-KEDTMEVEEFLKEAAVMKEIKHPN 311

  Fly   458 VLKFIGVLYKDKKLHMVTEYVAGGCLKELIHD------PAQVLPWPQRVRLARDIACGMSYLHSM 516
            :::.:||..::...:::||::..|.|.:.:.:      .|.||     :.:|..|:..|.||...
Zfish   312 LVQLLGVCTREPPFYIITEFMTHGNLLDYLRECNRQEVNAVVL-----LYMATQISSAMEYLEKK 371

  Fly   517 NIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRS 581
            |.|||||.:.||||.|:..|.||||||:|.          ||...|.:.|.:..|:.
Zfish   372 NFIHRDLAARNCLVGENNLVKVADFGLSRL----------MTGDTYTAHAGAKFPIK-------- 418

  Fly   582 KSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQ 646
                            |.|||.:...|:..|.||::||::|.||.....:....:..:..:.|.:
Zfish   419 ----------------WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE 467

  Fly   647 QEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDLA-ADRVPPE-------RL 703
            :::|......|||...::...|...||..||.|...|...:.:..:.: :|.|..|       ..
Zfish   468 KDYRMDRPEGCPEKVYELMRACWRWNPAERPSFAETHQAFETMFQESSISDEVEKELGKKGKKLT 532

  Fly   704 LHEIETFQEWYASSEDALSPTSQRSLNNLDELVKSAVDSEISPVEKEKENMVIKPQDIPKSPHLG 768
            |..|:...|....:.....||..|..::.|     |.::|::           .|..:|: |.|.
Zfish   533 LGPIQQAPELPTKTRTLRRPTDGRDGDSPD-----AAEAEVT-----------GPPMMPR-PLLD 580

  Fly   769 KDFSPSGERLRDSMRARRRQRFLGAQEERRNLTPDTESKERALKKALKKCRPFGERGYLVDLRA- 832
            .:.: ..:||:..   ..:.:|      |.|.....:.|:|......|:...||:....:|.|.
Zfish   581 SNLN-EDDRLQSK---DNKDKF------RMNPFSYIKKKKRTAPAPPKRSSSFGKMDGHLDRRGL 635

  Fly   833 GAELQLEDVRDLNTYSDVDSSCD-------TSLNYHDVNN---------LPAAQEDENTVKPGKE 881
            |.:.: ||..:.::.:|..:|.|       .|.....|.|         .|:....:.|...|..
Zfish   636 GTDCR-EDFSNGSSTNDALNSIDPCKLVGSNSTTTIGVTNGAPVYPGQLFPSHPRKKGTTSGGGG 699

  Fly   882 ELLEESTNKPSNQESQHH--RLAIDDMRTRLNQCRSKFEHLEEASRRNFNQSQHSMKNFFKTPPV 944
            :|   :|..|..::|..:  |.......:.:.....:||.......|:. ||.|...|.|:..|.
Zfish   700 KL---ATTPPPEEDSMSNSKRFLRSSSSSSMPPGSDRFEWKSVTLPRDI-QSTHFDSNTFRGKPA 760

  Fly   945 ALKMFQRLEHEAAALNGGNNCPPP--PPRTQRINQ-----------------TPIFGRKN----- 985
                   |..::....||...|||  |.:::.::.                 ||..||:.
Zfish   761 -------LPRKSCMPRGGTLTPPPRLPKKSEDVSDEVFKDSESSPGSSPLTLTPKLGRRPQTESS 818

  Fly   986 ---------------PPVAIVGQKLQHAESLE-----DLASSGVAKQLATPAPKRSKATATTKGG 1030
                           ||:...|:..:...|.|     :......||....|.|   ...::.|.|
Zfish   819 KTSALQTEVLKPNVLPPLGDEGRPRRLKLSSEIPGQREREKGKFAKPKPAPPP---PPVSSAKSG 880

  Fly  1031 QSSNPPLF-LPPSLNISVALNS--NGNVTTTTNTNSSCPPSASDWLPKKHKLTLPLPSAQQQRTS 1092
            ::|..|.| :.....:..:|:|  .|..:.:..:....|.:.|...|.|...|.|||
Zfish   881 KTSRSPTFEVSSDTKVKSSLDSADQGKASLSQESAKKLPKNGSKVNPSKAGATAPLP-------- 937

  Fly  1093 SNHRLPMCNNKGKTLKPLPSRTGSQGIPASNCVSPTRSSRPGSPTKHLAQRHTAATAQR------ 1151
                       |....|:....||..||    :..||.|...:|.:..::|.:::|..|
Zfish   938 -----------GMGASPVVGDPGSSFIP----LMTTRRSLRKAPARQPSERLSSSTITRDMLLES 987

  Fly  1152 ---LTNAAATHQQQHQQQSSKTTRLNILSPEK-VHRLGARLTDQKQKMREEAA 1200
               |..|.|...:|....|:      :|...| :.:......:..|:||.:.|
Zfish   988 SELLRTAIARVSEQTGSHSA------VLEAGKNLSKYCVSYVESIQQMRNKFA 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492
		STKc_LIMK	407..693	CDD:271056	77/291 (26%)
abl1	XP_005172104.1	SH3_Abl	79..132	CDD:212784
		SH2_ABL	137..230	CDD:198189	16/104 (15%)
		PTKc_Abl	249..511	CDD:270645	80/308 (26%)
		Pkinase_Tyr	256..507	CDD:285015	78/290 (27%)
		FABD	958..1081	CDD:197885	18/83 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910