Protein Alignment Pits and ST18

DIOPT Version :10

• Sequence 1: NP_001138192.1
• Gene: Pits / 32205
• FlyBaseID: FBgn0030400
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_055497.1
• Gene: ST18 / 9705
• HGNCID: 18695
• Length: 1047
• Species: Homo sapiens
• Alignment Length: 746
• Identity: 146/746 - (19%)
• Similarity: 217/746 - (29%)
• Gaps: 273/746 - (36%)

  Fly    32 RGCV---NYEGADR--IEAVLDAARQMKRLHPASKQQRSHENGEVSAAAAAAVVLQQQQQLQVGP 91
            ||||   .|:..||  :|.:....||.|.:....:|..::::..           :.:::....|
Human   316 RGCVFHNTYKELDRFLLEHLAGERRQTKVIDMGGRQIFNNKHSP-----------RPEKRETKCP 369

  Fly    92 VPG-QGPG-------SHRGGGGGGPPGAPP-----------GSGGPGPSGAGSLSSLGNA----- 132
            :|| .|.|       .||...|.......|           ....||.:|.|.::|..|.
Human   370 IPGCDGTGHVTGLYPHHRSLSGCPHKVRVPLEILAMHENVLKCPTPGCTGRGHVNSNRNTHRSLS 434

  Fly   133 ---VAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPVKLEDAPGGGVRPVRISHMTPHHLPPNATR 194
               :|||...|.....:|:                    |:|..|..|.: :|.|
Human   435 GCPIAAAEKLAMSQDKNQL--------------------DSPQTGQCPDQ-AHRT---------- 468

  Fly   195 GGGGAPGGGVPTAGSGGGSLPPALSVNLKRPPSEDVD---VDVSQQQQQSGHGLAPDGSAGNSLS 256
                              ||...:..|.   ||:.:.   ..||::|::  .|..|...|.....
Human   469 ------------------SLVKQIEFNF---PSQAITSPRATVSKEQEK--FGKVPFDYASFDAQ 510

  Fly   257 AGGGVSGGCPPGIKRSAMDDPSGVGGR--PPLTRGESLPAAVSYVPERQLSGLRDKQQPVRAPSF 319
            ..|          ||..:..   |.||  ||....:..|..|.: |.|..|.....|.|.||.|:
Human   511 VFG----------KRPLIQT---VQGRKTPPFPESKHFPNPVKF-PNRLPSAGAHTQSPGRASSY 561

  Fly   320 D-------------------ASTFKAANPIPNPIPHHLH----------------------IAEH 343
            .                   ::..:.|..|.:..|..||                      |.:.
Human   562 SYGQCSEDTHIAAAAAILNLSTRCREATDILSNKPQSLHAKGAEIEVDENGTLDLSMKKNRILDK 626

  Fly   344 MSPASRRNGS--SPPSGPLPPRSV----------------HSPNSSGSSSGRRSSGSRHVSSTTV 390
            .:|.:..|.|  :|.|.|....|:                .:|.:...:.|:..........:::
Human   627 SAPLTSSNTSIPTPSSSPFKTSSILVNAAFYQALCDQEGWDTPINYSKTHGKTEEEKEKDPVSSL 691

  Fly   391 TSSEVGGSNPGQAVV--------AGGL----------GGGGGGGPGSNAASGQLGGPSGGSGQLS 437
            .:.| ....||:|.:        |..|          |..|.|....|.||.:
Human   692 ENLE-EKKFPGEASIPSPKPKLHARDLKKELITCPTPGCDGSGHVTGNYASHR------------ 743

  Fly   438 CTSGGPGGSASSGSGGNGAIGPASMAPNSVAGDGSPAGGNGPSGSNGSGGSVNPGPGSSGSQGGG 502
            ..||.|....:..|         .||.||........|.:|.....|:..|.....|...::.||
Human   744 SVSGCPLADKTLKS---------LMAANSQELKCPTPGCDGSGHVTGNYASHRSLSGCPRARKGG 799

  Fly   503 GGGTPLASGG----------GSAGSGGLGGAPGSSAASNSAAAAAAAAAQN----ATLKCTLCQE 553
            ...||.....          |..|.|.:.|...|...::....||....:|    |:|...|.::
Human   800 VKMTPTKEEKEDPELKCPVIGCDGQGHISGKYTSHRTASGCPLAAKRQKENPLNGASLSWKLNKQ 864

  Fly   554 RLEDTHFVQCPSVNHHKFCFPCSRESIKRQNGLG--NEVYCP----SGDRCPLANSVIPWAFMQG 612
            .|.     .||               :...||||  |.|:..    ||  |||...||....:..
Human   865 ELP-----HCP---------------LPGCNGLGHVNNVFVTHRSLSG--CPLNAQVIKKGKVSE 907

  Fly   613 EITTI----------------LGEEVKVKKE 627
            |:.||                |.||:|...|
Human   908 ELMTIKLKATGGIESDEEIRHLDEEIKELNE 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:463250	11/29 (38%)
		vRING-HC_IRF2BP1-like	546..602	CDD:438174	16/61 (26%)
ST18	NP_055497.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..92
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..221
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	251..286
		zf-C2HC	367..393	CDD:460240	8/25 (32%)
		zf-C2HC	411..439	CDD:460240	6/27 (22%)
		MYT1	479..715	CDD:462489	45/252 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..563		14/40 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	672..710		5/38 (13%)
		zf-C2HC	723..751	CDD:460240	9/39 (23%)
		zf-C2HC	767..795	CDD:460240	5/27 (19%)
		zf-C2HC	815..843	CDD:460240	5/27 (19%)
		zf-C2HC	869..895	CDD:460240	11/42 (26%)
		Com_YlbF	921..1006	CDD:455416	5/18 (28%)