Protein Alignment Pits and IRF2BPL

DIOPT Version :10

• Sequence 1: NP_001138192.1
• Gene: Pits / 32205
• FlyBaseID: FBgn0030400
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_078772.1
• Gene: IRF2BPL / 64207
• HGNCID: 14282
• Length: 796
• Species: Homo sapiens
• Alignment Length: 853
• Identity: 253/853 - (29%)
• Similarity: 306/853 - (35%)
• Gaps: 294/853 - (34%)

  Fly     5 TKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLHPASKQQRS---- 65
            ::||.||||||||||||||.||||.|||||||||||||||.|::.|||:||.|...:..||
Human     9 SRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRAHGCFQDGRSPGPP 73

  Fly    66 ------------HENGEVSAAAAAAVVL---------QQQQQLQVGPVPGQGPGSHRGGGGGGPP 109
                        .|....:||||||...         |||||.|......|....:...|...|.
Human    74 PPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQQQQQQQQQQLNHVDGSSKPA 138

  Fly   110 --GAPPGSGGPGPSGAGSLSSLGNAVAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPVKLEDAPG 172
              .||.|....|.|.|        |.|||||||||....:..|..|...:|.. .:..:|.:..|
Human   139 VLAAPSGLERYGLSAA--------AAAAAAAAAAVEQRSRFEYPPPPVSLGSS-SHTARLPNGLG 194

  Fly   173 GGVRPVRISHMTPHHLPPNATR-------------GGGGAPGG---GVPTAGSGGGS-------- 213
            |   |......||...||...|             ...|..||   |:|..|.|||.
Human   195 G---PNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGLPNPGGGGGPQLTVPPNL 256

  Fly   214 LP------PALSVNLKRPPSEDVDVDVSQQQQQSGHGL--------APDGSAGNSLSAGGGVSGG 264
            ||      ||.:..|..||.               |.|        ||.|:.|.....||
Human   257 LPQTLLNGPASAAVLPPPPP---------------HALGSRGPPTPAPPGAPGGPACLGG----- 301

  Fly   265 CPPGIKRSAMDDPS-----------GVGGRPP--------------------------------- 285
             .||:..::....|           |.||:.|
Human   302 -TPGVSATSSSASSSTSSSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELSESLRNRA 365

  Fly   286 --------------LTRGESLPAAVSYVPERQLSGLRDKQQPVRAPSFD---------------- 320
                          ||.....|..|.:..:..|.|.......|..|..|
Human   366 EEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELKLFIEYPTGSGNV 430

  Fly   321 -----------------------ASTFK--------------------------------AANPI 330
                                   :|.||                                .|:.:
Human   431 YSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLLPEAVRFFKEGVPGADML 495

  Fly   331 PNPIPHHLHIAEHMSPA-----SRRNGSSPPSGPLPPRSVHSPNSSGSSSGRRSSGSRHVSSTTV 390
            |.|   :|..:..|.|.     ||...:.|.:|.|||.   :|:..|:::..|   .|..|....
Human   496 PQP---YLDASCPMLPTALVSLSRAPSAPPGTGALPPA---APSGRGAAASLR---KRKASPEPP 551

  Fly   391 TSSE----VGGSNPGQAVVAG-------GLGGGGGGGPGSNAASGQLGGPSGGSGQLSCTSGGPG 444
            .|:|    :|.....|..:|.       .:..||...||..|     |||......|     ||.
Human   552 DSAEGALKLGEEQQRQQWMANQSEALKLTMSAGGFAAPGHAA-----GGPPPPPPPL-----GPH 606

  Fly   445 GSASSGSGGNGAIGPASMAP-NSVAG---------DGSPAGGNGPSGSNGSGGSVNPG--PGSSG 497
            .:.::........||:.||. .|||.         |||.......|....|...|:|.  ||.
Human   607 SNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNSSSPVSPASVPGQ-- 669

  Fly   498 SQGGGGGGTPLASGGGSAGSGGLGGAPGSSAAS------NSAAAAAAAAAQNATLKCTLCQERLE 556
                    ..|||..|..   .|..||...:|.      :......:..|.:..|.||:|.||||
Human   670 --------RRLASRNGDL---NLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCTICHERLE 723

  Fly   557 DTHFVQCPSVNHHKFCFPCSRESIKRQNGLGNEVYCPSGDRCPLANSVIPWAFMQGEITTILGEE 621
            ||||||||||..|||||||||||||.|...| |||||||::|||..|.:|||||||||.|||..:
Human   724 DTHFVQCPSVPSHKFCFPCSRESIKAQGATG-EVYCPSGEKCPLVGSNVPWAFMQGEIATILAGD 787

  Fly   622 VKVKKERE 629
            |||||||:
Human   788 VKVKKERD 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:463250	41/50 (82%)
		vRING-HC_IRF2BP1-like	546..602	CDD:438174	43/55 (78%)
IRF2BPL	NP_078772.1	IRF-2BP1_2	10..61	CDD:463250	41/50 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..345		42/195 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..556		13/46 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..698		34/135 (25%)
		vRING-HC_IRF2BPL	708..773	CDD:438377	45/65 (69%)