DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pits and myt1la

DIOPT Version :9

Sequence 1:	NP_001138192.1	Gene:	Pits / 32205	FlyBaseID:	FBgn0030400	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001038364.1	Gene:	myt1la / 559505	ZFINID:	ZDB-GENE-041001-172	Length:	1257	Species:	Danio rerio

Alignment Length:	691	Identity:	141/691 - (20%)
Similarity:	205/691 - (29%)	Gaps:	225/691 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DAARQMKRLHPASKQQRSHENGEVSAAAAAAVVLQQQQQLQVGPVPGQGP---------GSHR-- 101
            |.||::....|:.:....|.....|..       ||.|.|...|.|...|         ..||
Zfish   361 DLARKLSETQPSERPLMEHHMQHHSEQ-------QQPQHLHPHPHPHHPPMPRYDSCQMDQHRPL 418

  Fly   102 -----------------GGGGGGPPGAPPGSGGPGPSGA-------------GSLSSLGNAVAAA 136
                             .....|.|.:....|....:..             |:||.|..|:|..
Zfish   419 ERNYSDMVNLMKLEEQLSPASRGYPSSCAQDGDEDTTSVASDRSDEAFDMTKGNLSLLEKAIALE 483

  Fly   137 AAAAAVHHHHQMPYQMPVPRIGPPLDYPVKLEDAPGGGVRPVRISHMTPHH------LPPNATRG 195
            :..|.|........||...|....|........:.....|..|:     ||      ..|..:|
Zfish   484 SERAKVMRDRMASEQMVARRDNQRLHGEHSPRQSSSAEERKARL-----HHDGAKRAYYPKDSR- 542

  Fly   196 GGGAPGGGVPTAGSGGGSLPPALSVNLKRPPSEDVDVDVSQQQQQSGH--GLAPDGSAGNSLSAG 258
             |.......||.|..|                             :||  ||.|.   ..|||
Zfish   543 -GEKKESKCPTPGCDG-----------------------------TGHVTGLYPH---HRSLS-- 572

  Fly   259 GGVSGGC------PPGI---KRSAMDDPS-GVGGRPPLTRGESLPAAVSYVP---ERQLSGLRDK 310
                 ||      ||.|   ..:.:..|: |..||..:....:...::|..|   ..:::.:::|
Zfish   573 -----GCPHKDRVPPEILAMYENVLKCPTPGCSGRGHVNSNRNSHRSLSGCPIAAAEKMAKVQEK 632

  Fly   311 QQPVRAPSFDASTFKAANP-----------------IPNPIPHHLHIA---EHMSPASRRNGSSP 355
            ......|..:.::.:...|                 :|...|.. ::|   |..|.||....::.
Zfish   633 HHSCDGPKSNQASDRVLRPMCFVKQLEIPEYGYKNNVPTSTPRS-NLAKELEKYSKASFDYSNTY 696

  Fly   356 PSGP-------LPPRSVHSPNSS--GSSSGRRSSGSRHVSSTTVTSSEVGGSNPGQAVVAGGLGG 411
            .:.|       |.|:| |..::|  |..:.|....|...||||   |....|:.......||.||
Zfish   697 ENQPHAYGKRSLIPKS-HGRDTSPKGYDAKRYCKTSSPASSTT---SSYAPSSSSSLSCGGGGGG 757

  Fly   412 GGGGGPGSNAASGQLGGPSGGSGQLSCTSGGPGGSASSGSGGNGAIGPASMA------PNSVAGD 470
            |||||.||:|:|             :|:......:....:....|....:::      |.|:|..
Zfish   758 GGGGGGGSSASS-------------TCSKSSFDYTHDMEAAHMAATAILNLSTRCREMPQSLAAK 809

  Fly   471 GSPAGGNGPSGSNGSGGSVNPGPGSSGSQGGGGGGTPLASGGGSAGSGGLGGAPGSSAASNSAAA 535
            |.......|...:|. .|.....|..|..|.|.|||.|              .|....:....|.
Zfish   810 GPELLAQSPDDRDGD-DSRALDVGRVGGMGEGSGGTVL--------------TPLQPMSPQRQAL 859

  Fly   536 AAAAAAQNATLKC----------------------TLCQERLEDTHF---VQCPSVNHHKFCFPC 575
            ..:...|.:|..|                      ...|:.|||..:   |..||.. ||:. ||
Zfish   860 LNSHCYQMSTADCWDLPVDYTKIKRLDDDHKEDDLDPFQDLLEDQQYSGEVSLPSPK-HKYA-PC 922

  Fly   576 SRESIKRQNGLGNEVYCPSGDRCPLANSVIPWAFMQGEITT 616
             :||.|....|.:         |.||:.     .|:|.:|:
Zfish   923 -KESKKELLTLSS---------CQLADK-----GMRGMMTS 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:288155	3/8 (38%)
Pits	NP_001138192.1	zf-C3HC4	548..593	CDD:278524	16/69 (23%)
myt1la	NP_001038364.1	zf-C2HC	26..52	CDD:279824
		zf-C2HC	549..575	CDD:279824	13/64 (20%)
		zf-C2HC	593..619	CDD:279824	5/25 (20%)
		MYT1	665..922	CDD:285648	66/291 (23%)
		zf-C2HC	954..980	CDD:279824
		zf-C2HC	1003..1029	CDD:279824
		zf-C2HC	1057..1082	CDD:279824
		DUF342	<1112..1185	CDD:302792
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594279
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930