DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pits and irf2bp2

DIOPT Version :9

Sequence 1:	NP_001138192.1	Gene:	Pits / 32205	FlyBaseID:	FBgn0030400	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001001988.1	Gene:	irf2bp2 / 394851	XenbaseID:	XB-GENE-1015579	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	671	Identity:	214/671 - (31%)
Similarity:	272/671 - (40%)	Gaps:	187/671 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLHPASKQQRS---- 65
            ::||.||||||||||||||.||:|.|||||||||||||||.|::.||.:||.| ..::.||
Frog     9 SRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRIEFVIETARHLKRAH-GFQEGRSPGPS 72

  Fly    66 -HENGEVSAAAAAAVVLQQQQQLQVGPVPGQGPGSHRGGGGGG-------PPGAPP------GSG 116
             ..:...|::::....|..::..|:|         |..||..|       ||  ||      ...
Frog    73 PSSSSSSSSSSSVKPQLSAKEMAQIG---------HTMGGPEGVTRTSQQPP--PPQCLDRYSLE 126

  Fly   117 GPGPSGAGSLSSLGNAVAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPVKLEDAPGGGVRPVRIS 181
            .|.|...||...:|..|....          :|...|.|...|.|:     ..:|    .|.|.|
Frog   127 RPPPPRLGSEYGVGRQVNGIL----------LPNGFPKPEEPPELN-----RQSP----NPRRTS 172

  Fly   182 HMTPHHLPPNATRGGGGAPGGGVPTAGSGGGSLPPALS-VNLKRPPSEDVDVDVSQQQQQSGHGL 245
            .: |..|         ||...|.|.   |.|..|..|| .:|....:.....|:|        |.
Frog   173 SV-PQSL---------GALMNGAPI---GSGRTPVGLSAASLVAAAAATTSADLS--------GK 216

  Fly   246 APDGSAGNSLSAGGGVSGGCPPGIKRSAMDDPSGVG-----------GRPPLTRGESLPAAVSYV 299
            .|           |.||.....|.::...|..|.:|           .:|...|...:....|:.
Frog   217 RP-----------GSVSSSEHDGKEKHRADSYSELGENHKSRAEEWISKPKTVRDTLMAMQHSHS 270

  Fly   300 PERQLSGLRDKQQPVRAPSFDASTFKAANPI------------PNPIPHHLHIAEHMSPASRRNG 352
            |..  |..:....|.|..||:|:     ||.            |:|.|      |....:.:.||
Frog   271 PFD--SKFKKDPGPGRVLSFEAN-----NPASKSGARGGRKRKPSPEP------EGEGGSVKMNG 322

  Fly   353 SSPPSGPLPPRSVHSPNSSGSSSGRRSSGSRHVSSTTVTSSEVGGSNPGQAVVAGGLGGGGGGGP 417
            ...|..|.......|..:|.|.....|:.|.|.:.||...:...|.:|..|::.  :....||..
Frog   323 EGQPWLPAAESLKISTMASPSFISPPSTVSPHSNRTTPPEAAQNGQSPMAALIL--VADNAGGNH 385

  Fly   418 GSNAASGQLGGPSGGSGQLSCTSGGPGGSASSGSGGNGAIGPASMAPNSVAGDGSPAGGNGPSGS 482
            .|..|:           |:..|:.....|..|.|..|    ...|||..|           ||
Frog   386 ASKDAN-----------QVHSTTRRNSSSPPSPSSMN----QRRMAPRDV-----------PS-- 422

  Fly   483 NGSGGSVNPGPGSSGSQGGGGGGTPLASGGGSAGSGGLGGAPGS---SAASNSAAAAAAAAAQNA 544
                                    .:.|||.|:.:|...|.|.|   |:..||           .
Frog   423 ------------------------QIPSGGTSSHAGMEQGHPQSIPDSSIPNS-----------I 452

  Fly   545 TLKCTLCQERLEDTHFVQCPSVNHHKFCFPCSRESIKRQNGLGNEVYCPSGDRCPLANSVIPWAF 609
            .|.||||.||||||||||||||..|||||||||:|||:| |...|||||||::|||..|.:||||
Frog   453 PLCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQ-GSSGEVYCPSGEKCPLVGSNVPWAF 516

  Fly   610 MQGEITTILGEEVKVKKERES 630
            |||||.|||..:|||||||:|
Frog   517 MQGEIATILAGDVKVKKERDS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:288155	39/50 (78%)
Pits	NP_001138192.1	zf-C3HC4	548..593	CDD:278524	35/44 (80%)
irf2bp2	NP_001001988.1	IRF-2BP1_2	11..60	CDD:371437	38/48 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..186		35/166 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..366		39/189 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..446		24/115 (21%)
		vRING-HC_IRF2BP1_like	454..509	CDD:319425	43/55 (78%)
		variant RING-HC finger (C3HC4-type)	456..505	CDD:319425	39/49 (80%)
		Cys-rich	456..503		38/47 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I4443
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46167
OrthoDB	1	1.010	-	-		D1156771at2759
OrthoFinder	1	1.000	-	-		FOG0001640
OrthoInspector	1	1.000	-	-		otm49030
Panther	1	1.100	-	-	O	PTHR10816
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1040
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.120