DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pits and IRF2BP2

DIOPT Version :9

Sequence 1:	NP_001138192.1	Gene:	Pits / 32205	FlyBaseID:	FBgn0030400	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_892017.2	Gene:	IRF2BP2 / 359948	HGNCID:	21729	Length:	587	Species:	Homo sapiens

Alignment Length:	696	Identity:	222/696 - (31%)
Similarity:	287/696 - (41%)	Gaps:	189/696 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLHPASKQQRSHENG 69
            ::||.||||||||||||||.||:|.|||||||||||||:|.|::.|||:||.|....:.||....
Human    11 SRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLKRAHGCFPEGRSPPGA 75

  Fly    70 EVSAAA------AAAVVLQQQQQLQVGPVPGQGPGSHRGGGGGGPPGAPPGSGG----PGPSGAG 124
            ..||||      |..::|||||||                |.|||..||.....    |..:.|.
Human    76 AASAAAKPPPLSAKDILLQQQQQL----------------GHGGPEAAPRAPQALERYPLAAAAE 124

  Fly   125 SLSSLGNAVAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPV----------KLEDAP-------- 171
            ....||:...::..||::       .|.|.|:  ||   ||          |||:.|
Human   125 RPPRLGSDFGSSRPAASL-------AQPPTPQ--PP---PVNGILVPNGFSKLEEPPELNRQSPN 177

  Fly   172 ---GGGVRPVRISHMTPHHLP-PNATRGGGGAPGGGVPTAGSGGGSLPPALSVNL---KRPPSED 229
               |..|.|..:..|.....| |.|...||.|.......:|:...||..|...:|   |||.|..
Human   178 PRRGHAVPPTLVPLMNGSATPLPTALGLGGRAAASLAAVSGTAAASLGSAQPTDLGAHKRPASVS 242

  Fly   230 VDVDVSQQQQQSG---HGLAPDGSAG--NSLSAGGGVSGGCPPGIKRSAMDDPSGVGGRPPLTR- 288
            ....|..:|:::.   ....|....|  :|||...|.:.....|..:|..........||...|
Human   243 SSAAVEHEQREAAAKEKQPPPPAHRGPADSLSTAAGAAELSAEGAGKSRGSGEQDWVNRPKTVRD 307

  Fly   289 --------GESLPAAVSYVPERQLSGLRDKQQPV----RAPSFDASTFKAANPIPNPIPHHLHIA 341
                    |.|.|....:           |::|.    |...|:|:....:..:..
Human   308 TLLALHQHGHSGPFESKF-----------KKEPALTAGRLLGFEANGANGSKAVAR--------- 352

  Fly   342 EHMSPASRRNGSSPPSGPLPPRSVH---SPNSSGSSSGRR--------------SSGSRHVSSTT 389
                .|.:|..|..|.|.:.|..::   .|..|.|:.|.:              .:.|.|.:.||
Human   353 ----TARKRKPSPEPEGEVGPPKINGEAQPWLSTSTEGLKIPMTPTSSFVSPPPPTASPHSNRTT 413

  Fly   390 VTSSEVGGSNPGQAVVAGGLGGGGGGGPGSNAASGQLGGPSGGSGQLSCTSGGPGGSASSGSGGN 454
            ...:...|.:|..|::.  :....||...|..|:           |:..|:.....|..|
Human   414 PPEAAQNGQSPMAALIL--VADNAGGSHASKDAN-----------QVHSTTRRNSNSPPS----- 460

  Fly   455 GAIGPASMAPNSVAGDGSPAGGNGPSGSNGSGGSVNPGPGSSGSQGGGGGGTPLASGGGSAGSGG 519
                |:||....:                        ||...|.||.|             .:||
Human   461 ----PSSMNQRRL------------------------GPREVGGQGAG-------------NTGG 484

  Fly   520 LGGAPGSSAASNSAAAAAAAAAQNATLKCTLCQERLEDTHFVQCPSVNHHKFCFPCSRESIKRQN 584
            |.....:|...:|.|.       :|.|.||||.||||||||||||||..|||||||||:|||:|
Human   485 LEPVHPASLPDSSLAT-------SAPLCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQ- 541

  Fly   585 GLGNEVYCPSGDRCPLANSVIPWAFMQGEITTILGEEVKVKKERES 630
            |...|||||||::|||..|.:|||||||||.|||..:|||||||:|
Human   542 GASGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDS 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:288155	39/50 (78%)
Pits	NP_001138192.1	zf-C3HC4	548..593	CDD:278524	35/44 (80%)
IRF2BP2	NP_892017.2	IRF-2BP1_2	12..63	CDD:288155	39/50 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..192		18/77 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..306		18/80 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..420		14/90 (16%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:21887377	354..361		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	437..494		20/113 (18%)
		Cys-rich	506..550		35/44 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158354
Domainoid	1	1.000	157	1.000	Domainoid score	I4155
eggNOG	1	0.900	-	-		E1_KOG3579
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46167
OrthoDB	1	1.010	-	-		D1156771at2759
OrthoFinder	1	1.000	-	-		FOG0001640
OrthoInspector	1	1.000	-	-		otm41805
orthoMCL	1	0.900	-	-		OOG6_110480
Panther	1	1.100	-	-	O	PTHR10816
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1040
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.810