Protein Alignment Pits and Irf2bpl

DIOPT Version :10

• Sequence 1: NP_001138192.1
• Gene: Pits / 32205
• FlyBaseID: FBgn0030400
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_001012488.2
• Gene: Irf2bpl / 314329
• RGDID: 1310994
• Length: 782
• Species: Rattus norvegicus
• Alignment Length: 817
• Identity: 250/817 - (30%)
• Similarity: 304/817 - (37%)
• Gaps: 236/817 - (28%)

  Fly     5 TKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLHPASKQQRSH--- 66
            ::||.||||||||||||||.||||.|||||||||||||||.|::.|||:||.|...:..||.
  Rat     9 SRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRAHGCFQDGRSPGPP 73

  Fly    67 --------ENGEVSAAAAAAVVLQQQQQLQVGPVPGQGPGSHRGGGGGGPPGAPPGSGGPGPSGA 123
                    ......||||||...|||||.|......|.|.......|...|...     |.|||.
  Rat    74 PPVGVKTVALSAKEAAAAAAAAQQQQQQQQQQQQQQQQPQQLNHVDGSTKPAVL-----PAPSGL 133

  Fly   124 GSLSSLGNAVAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPVKLEDAPGGGVRPVRISHMTPHHL 188
            ........|.|||||||||....:..|..|...:|.. .:..:|.:..||   |.......|...
  Rat   134 ERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPVSLGSS-SHAARLPNGLGG---PNGFPKPAPEEG 194

  Fly   189 PPNATR-------------GGGGAPGG---GVPTAGSGGGSLPPALSVNLKRPPSEDVDVDVSQQ 237
            ||...|             ...|...|   |:|..|.|||   |.|:|.....|...::...|..
  Rat   195 PPELNRQSPNSSSAATSVASRRGTHSGLVTGLPNPGGGGG---PQLTVPPNLLPQTLLNGPASAA 256

  Fly   238 QQQSGHGLAPDGSAGNSLSAGGGVSGG--C---PPGIKRSAMDDPS---------GVG--GRPP- 285
            .....|||.  ||.|....|..|..||  |   |||:..:....||         |||  |:.|
  Rat   257 VLPPPHGLG--GSRGPPTPAPPGAPGGPACLGGPPGVSATVSSAPSSTSSTVAEVGVGAAGKRPG 319

  Fly   286 ----------------------------------------------LTRGESLPAAVSYVPERQL 304
                                                          ||.....|..|.:..:..|
  Rat   320 SVSSTDQERELKEKQRNAEALAELSESLRNRAEEWANKPKMVRDTLLTLAGCTPYEVRFKKDHSL 384

  Fly   305 SGLRDKQQPVRAPSFD---------------------------------------ASTFK----- 325
            .|.......|..|..|                                       :|.||
  Rat   385 LGRVFAFDAVSKPGMDYELKLFIEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYE 449

  Fly   326 ---------------------------AANPIPNPIPHHLHIAEHMSPA-----SRRNGSSPPSG 358
                                       .|:.:|.|   :|..:..|.|.     ||...:.|.:|
  Rat   450 KKHGSGDWRLLGDLLPEAVRFFKEGVPGADMLPQP---YLDASCPMLPTALVSLSRAPSAPPGTG 511

  Fly   359 PLPPRSVHSPNSSGSSSG-RRSSGSRHVSSTTVTSSEVGGSNPGQAVVAG-------GLGGGGGG 415
            .|||.   :|...|:::. |:...|.....:..::.::|.....|..:|.       .:..||..
  Rat   512 ALPPA---APTGRGAAASLRKRKASPEPPDSAESALKLGEEQQRQQWMANQSEALKLTMSAGGFA 573

  Fly   416 GPGSNAASGQLGGPSGGSGQLSCTSGGPGGSASSGSGGNGAIGPASMAP-NSVAG---------D 470
            .||..|     |||......|     ||..:.::........||:.||. .|||.         |
  Rat   574 APGHAA-----GGPPPPPPPL-----GPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKD 628

  Fly   471 GSPAGGNGPSGSNGSGGSVNPG--PGSSGSQGGGGGGTPLASGGGSAGSGGLGGAPGSSAAS--- 530
            ||.......|....|...|:|.  ||.          ..|||..|..   .|..||...:|.
  Rat   629 GSSVHSTTASARRNSSSPVSPASVPGQ----------RRLASRNGDL---NLQVAPPPPSAHPGM 680

  Fly   531 ---NSAAAAAAAAAQNATLKCTLCQERLEDTHFVQCPSVNHHKFCFPCSRESIKRQNGLGNEVYC 592
               :......:..|.:..|.||:|.||||||||||||||..|||||||||||||.|...| ||||
  Rat   681 DQVHPQNIPDSPMANSGPLCCTICHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATG-EVYC 744

  Fly   593 PSGDRCPLANSVIPWAFMQGEITTILGEEVKVKKERE 629
            |||::|||..|.:|||||||||.|||..:|||||||:
  Rat   745 PSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERD 781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:463250	41/50 (82%)
		vRING-HC_IRF2BP1-like	546..602	CDD:438174	43/55 (78%)
Irf2bpl	NP_001012488.2	IRF-2BP1_2	10..61	CDD:463250	41/50 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..330		44/177 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..543		11/44 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	571..691		34/142 (24%)
		vRING-HC_IRF2BPL	694..759	CDD:438377	45/65 (69%)