DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pits and Irf2bp2

DIOPT Version :9

Sequence 1:	NP_001138192.1	Gene:	Pits / 32205	FlyBaseID:	FBgn0030400	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001158070.1	Gene:	Irf2bp2 / 270110	MGIID:	2443921	Length:	570	Species:	Mus musculus

Alignment Length:	700	Identity:	221/700 - (31%)
Similarity:	287/700 - (41%)	Gaps:	214/700 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLHPASKQQRSHENG 69
            ::||.||||||||||||||.||:|.|||||||||||||:|.|::.|||:||.|....:.||
Mouse    11 SRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLKRAHGCFPEGRS---- 71

  Fly    70 EVSAAAAAAVVLQQQQQLQVGPVPGQGPGSHRGGGGGGPPGAPPGSGGPGPSGAGSL-----SSL 129
                                                  |.||.|.:..|.|..|..|     ..|
Mouse    72 --------------------------------------PTGAQPAAAKPPPLSAKDLLLQPPPQL 98

  Fly   130 GNAVAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPVKLEDAPGGGVRPVRISHMTPHHLPPNATR 194
            |:|.|.||.|.|:..                  ||:..:.||       |::       ...:||
Mouse    99 GHAGAEAARAQAMER------------------YPLAPDRAP-------RLA-------SDFSTR 131

  Fly   195 GGGGAPGGGVPTAGSGGGSLPPALSVNLKRPPSEDVDVDVSQQQQQSGHGLAP------DGSAGN 253
            .|.|.|......:....|.|.|.....|:.||    :::......:..|.:.|      :|||..
Mouse   132 AGAGLPQSAAQQSAPANGILVPNGFSKLEEPP----ELNRQSPNPRRAHAVPPTLVPLVNGSAAL 192

  Fly   254 SLSAGGGVSGGCPPGIKRSAMDDPSGVGGRPPLTRGESLPAAVSYVPERQLSGLRDKQQPVRAPS 318
            .||.....:        .:|:....|:|.:|........||:||...         .:...|.||
Mouse   193 GLSGRAAAT--------LAAVSGTPGLGAQPAELGTHKRPASVSSAA---------AEHEAREPS 240

  Fly   319 FDASTFKAANPIPNPIPHHLHIAEHMSPASRRNGSSPPSGPLPPRSVHSPNSSGSSSGRR----- 378
            .:.:.           |.|...|:.:|.|:   |:|..|            :.|:..||.
Mouse   241 KEKAQ-----------PAHRSPADSLSSAA---GASELS------------AEGAGKGRAPGEQD 279

  Fly   379 -SSGSRHVSSTTVTSSEVGGSNPGQ-------AVVAGG--LGGGGGGGPGSNAAS---------- 423
             :|..:.|..|.:...:.|.|.|.:       |:.|.|  ||....|..||.|.:
Mouse   280 WASRPKTVRDTLLALHQHGHSGPFESKFKKEPALTAAGRLLGFEANGANGSKAVARTARKRKPSP 344

  Fly   424 ---GQLGGPS-GGSGQ--LSCTSGG------PGGSASSGSGGNGAIGPASMAPNSVAGDGSPAGG 476
               |::|.|. .|..|  ||.::.|      |..|..|..       |.:.:|:|.......|..
Mouse   345 EPEGEVGPPKINGETQPWLSTSTEGLKIPITPTSSFVSPP-------PPTASPHSNRTTPPEAAQ 402

  Fly   477 NGPS-------------GSNGS------------GGSVNPGPGSSGSQGGGGGGTPLASGGGSAG 516
            ||.|             ||:.|            ..|..|.|.|...:..|    |...||.:.|
Mouse   403 NGQSPMAALILVADNAGGSHASKDATQVHSTTRRNSSSPPSPSSMNQRRLG----PREVGGQATG 463

  Fly   517 S-GGLGGAPGSSAASNSAAAAAAAAAQNATLKCTLCQERLEDTHFVQCPSVNHHKFCFPCSRESI 580
            | |||.....:|...:|.||       :|.|.||||.||||||||||||||..|||||||||:||
Mouse   464 STGGLEPVHPASLPDSSLAA-------SAPLCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSI 521

  Fly   581 KRQNGLGNEVYCPSGDRCPLANSVIPWAFMQGEITTILGEEVKVKKERES 630
            |:| |...|||||||::|||..|.:|||||||||.|||..:|||||||:|
Mouse   522 KQQ-GASGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDS 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:288155	39/50 (78%)
Pits	NP_001138192.1	zf-C3HC4	548..593	CDD:278524	35/44 (80%)
Irf2bp2	NP_001158070.1	IRF-2BP1_2	12..63	CDD:288155	39/50 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..85		7/60 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..179		12/52 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..283		19/104 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..403		18/80 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..477		17/61 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848750
Domainoid	1	1.000	199	1.000	Domainoid score	I3063
eggNOG	1	0.900	-	-		E1_KOG3579
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	283	1.000	Inparanoid score	I2852
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46167
OrthoDB	1	1.010	-	-		D1156771at2759
OrthoFinder	1	1.000	-	-		FOG0001640
OrthoInspector	1	1.000	-	-		otm43857
orthoMCL	1	0.900	-	-		OOG6_110480
Panther	1	1.100	-	-	O	PTHR10816
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1040
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860