DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pits and St18

DIOPT Version :9

Sequence 1:	NP_001138192.1	Gene:	Pits / 32205	FlyBaseID:	FBgn0030400	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_695222.2	Gene:	St18 / 266680	RGDID:	708566	Length:	1044	Species:	Rattus norvegicus

Alignment Length:	732	Identity:	141/732 - (19%)
Similarity:	193/732 - (26%)	Gaps:	322/732 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 GSLSSLGNAVAAAAAAAAVHHH----------HQMPYQMPVPRIGPPLDYPVKLEDAPGGGV--- 175
            ||||.|..|:|..|...:|.||          ..:..|...|          |:.||.|..:
  Rat   298 GSLSLLEQAIALQAERGSVFHHTYKELDRFLLDHLARQRRQP----------KVTDASGRQIFNN 352

  Fly   176 ----RPVR------------ISHMT---PHHLPPNATRGGGGAPGG---------------GVPT 206
                ||.|            ..|:|   |||      |...|.|..               ..||
  Rat   353 KHSPRPERREAKCPIPGCDGTGHVTGLYPHH------RSLSGCPHKVRVPLEILAMHENVLKCPT 411

  Fly   207 AGSGGGSLPPALSVNLKRPPSEDVDVDVSQQQQQSGHGLAPDGSAGNSLSAGGGVSGGCP-PGIK 270
            .|..|                             .|| :..:.:...|||       ||| ...:
  Rat   412 PGCTG-----------------------------RGH-VNSNRNTHRSLS-------GCPIAAAE 439

  Fly   271 RSAMD------DPSGVGGRPPLTRGESLPAAVSY------VPERQLSGLRDKQQPVRAP----SF 319
            :.||.      |.|..|..|......:|...:.:      :...:.|..:::::..:.|    ||
  Rat   440 KLAMTQDKSQLDSSQTGQGPEQAHRVNLVKQIEFNFRSQAITSPRASASKEQEKFGKVPFDYASF 504

  Fly   320 DASTFKAANPIPNPIPHHLHIAEHMSPASRRNGSSPPSGPLPPRSVHSPNSSGSSSGRRSSGSRH 384
            ||..| ...|:                  .:.|....:.|. |.|.|..|....|:|..|:|: |
  Rat   505 DAQVF-GKRPL------------------LQTGQGQKAPPF-PESKHFSNPVKFSNGLPSAGA-H 548

  Fly   385 VSSTTVTSSEVGGSNPGQAVVAGGLGGGGGGGPGSNAASGQLGGPSGGSGQLSCTSGGPGGSASS 449
            ..||...||...|.......:|              ||:..|...:.........|..|....:.
  Rat   549 TQSTVRASSYGHGQYSEDTHIA--------------AAAAILNLSTRCREATDILSNKPQSLRAK 599

  Fly   450 GS----GGNG--------------AIGPASMAPNSVAGDGSP-------------------AGGN 477
            |:    ..||              :|.|.|..........||                   .|.|
  Rat   600 GAEIEVDENGTLDLSMKKHRILDKSIPPTSSHTTIATPSSSPFKASSLLVNAAFYQALCDQEGWN 664

  Fly   478 GPSGSNGSGGS---------VN-----------------------------------PGPGSSGS 498
            .|...:.|.|.         ||                                   |.||..||
  Rat   665 VPINYSKSHGKTEEEKEKDPVNSLENLEEKKFAGEASIPSPKPKLHTRDLKKELITCPTPGCDGS 729

  Fly   499 QGGGG--------GGTPLASGG--------------GSAGSGGLGGAPGSSAASNSAAAAAAAAA 541
            ....|        .|.|||...              .:.|..|.|...|:.|:..|  .:....|
  Rat   730 GHVTGNYASHRSVSGCPLADKTLKSLMAANSQELKCPTPGCDGSGHVTGNYASHRS--LSGCPRA 792

  Fly   542 QNATLKCTLCQERLEDTHFVQCPSV------------NHHKFCFPCSRESIKRQ----------- 583
            :...:|.|..:|..||:. ::||.:            ..|:....|.. :.|||
  Rat   793 RKGGIKMTPTKEEKEDSE-LRCPVIGCDGQGHISGKYTSHRTASGCPL-AAKRQKENPLNGTPLS 855

  Fly   584 ----------------NGLG--NEVYCP----SGDRCPLANSVIPWAFMQGEITTI--------- 617
                            ||||  |.|:..    ||  |||....|....:..|:.||
  Rat   856 WKLNKQELPHCPLPGCNGLGHVNNVFVTHRSLSG--CPLNAQAIKKVKVSEELMTIKLKATGGIE 918

  Fly   618 -------LGEEVKVKKE 627
                   |.||:|...|
  Rat   919 GDEEIRHLDEEIKELNE 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:288155
Pits	NP_001138192.1	zf-C3HC4	548..593	CDD:278524	17/85 (20%)
St18	NP_695222.2	zf-C2HC	364..390	CDD:279824	7/31 (23%)
		zf-C2HC	408..434	CDD:279824	10/62 (16%)
		MYT1	477..712	CDD:285648	45/269 (17%)
		zf-C2HC	721..746	CDD:279824	7/24 (29%)
		zf-C2HC	764..790	CDD:279824	6/27 (22%)
		zf-C2HC	812..838	CDD:279824	3/25 (12%)
		zf-C2HC	866..891	CDD:279824	8/26 (31%)
		Com_YlbF	920..1003	CDD:294880	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352351
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930