Protein Alignment Pits and IRF2BP1

DIOPT Version :10

• Sequence 1: NP_001138192.1
• Gene: Pits / 32205
• FlyBaseID: FBgn0030400
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_056464.1
• Gene: IRF2BP1 / 26145
• HGNCID: 21728
• Length: 584
• Species: Homo sapiens
• Alignment Length: 750
• Identity: 228/750 - (30%)
• Similarity: 293/750 - (39%)
• Gaps: 298/750 - (39%)

  Fly     5 TKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLH----------PA 59
            ::||.|||||||:|||||:.||||||||||||:|||||||.::|||||:||.|          ||
Human     7 SRRQWCYLCDLPKMPWAMVWDFSEAVCRGCVNFEGADRIELLIDAARQLKRSHVLPEGRSPGPPA 71

  Fly    60 SKQQRSHENGEVSAAAAAAVVLQQQQQLQVGPVPGQGPGSHRGGGGGGPPGAPPGSGGPGPSGAG 124
            .|...:.:     .|||||                ||            |..||....|.|||.|
Human    72 LKHPATKD-----LAAAAA----------------QG------------PQLPPPQAQPQPSGTG 103

  Fly   125 SLSSLGNAVAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPV--KL------EDAPGGGVRPVRIS 181
            ...|..:....|.::.          ::|:|  .|.|:|.:  :|      |:|...|.|...:.
Human   104 GGVSGQDRYDRATSSG----------RLPLP--SPALEYTLGSRLANGLGREEAVAEGARRALLG 156

  Fly   182 HMTPHHLPPNATRGGGGAPGGGVPTAGSGGGSLPPALSVNLKRPPSEDV---DVDVSQQQQ---- 239
            .| |..:||       |.....|...||.|.:|.|.||      |:..:   |.:..:||:
Human   157 SM-PGLMPP-------GLLAAAVSGLGSRGLTLAPGLS------PARPLFGSDFEKEKQQRNADC 207

  Fly   240 ---------------------------------------QSGHGL-----APDGSAGNSLSAGGG 260
                                                   :..|||     |.|.:|.
Human   208 LAELNEAMRGRAEEWHGRPKAVREQLLALSACAPFNVRFKKDHGLVGRVFAFDATAR-------- 264

  Fly   261 VSGGCPPGIK---RSAMDDPSGVGG-----------------RPPLTRGESLPAA----VSYVPE 301
                 |||.:   :...:.|.|.|.                 |.|   |::|.::    :.|...
Human   265 -----PPGYEFELKLFTEYPCGSGNVYAGVLAVARQMFHDALREP---GKALASSGFKYLEYERR 321

  Fly   302 ------RQL-----SGLRDKQQPVRAPSFDASTFKAANPIPNPIPHHLHIAEHMSPASRRNGSSP 355
                  |||     .|:|..::|  ||         |..:|...|         .||.......|
Human   322 HGSGEWRQLGELLTDGVRSFREP--AP---------AEALPQQYP---------EPAPAALCGPP 366

  Fly   356 PS------GPLPPRSVHSPNSSGSSSGRRSS---GSRH-VSSTTVTSSEVGG-SNPGQAV--VAG 407
            |.      .|.|.|...||...|.::|:.::   ..|| |:.....|:|..| .:|..|:  ||.
Human   367 PRAPSRNLAPTPRRRKASPEPEGEAAGKMTTEEQQQRHWVAPGGPYSAETPGVPSPIAALKNVAE 431

  Fly   408 GLG-----GGGGGGPGSNAASGQLGGPSGGSGQLSCTSGGPGGSASSGSGGNGAIGPASMAPNS- 466
            .||     .||||||                    ..:||...:|||          .:..|..
Human   432 ALGHSPKDPGGGGGP--------------------VRAGGASPAASS----------TAQPPTQH 466

  Fly   467 --VAGDGSPAGGNGPSGSNGSGGSVNPGPGSSGSQGGGGGGTPLASGGGSAGSGGLGGAPGSSAA 529
              ||.:|.              ..|:|..|:....|||            :|:|...|||
Human   467 RLVARNGE--------------AEVSPTAGAEAVSGGG------------SGTGATPGAP----- 500

  Fly   530 SNSAAAAAAAAAQNATLKCTLCQERLEDTHFVQCPSVNHHKFCFPCSRESIKRQNGLGNEVYCPS 594
                            |.||||:||||||||||||||..||||||||||.||.| |...||||||
Human   501 ----------------LCCTLCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQ-GPAGEVYCPS 548

  Fly   595 GDRCPLANSVIPWAFMQGEITTILGEEVKVKKERE 629
            ||:|||..|.:|||||||||.|||..::||||||:
Human   549 GDKCPLVGSSVPWAFMQGEIATILAGDIKVKKERD 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:463250	40/50 (80%)
		vRING-HC_IRF2BP1-like	546..602	CDD:438174	44/55 (80%)
IRF2BP1	NP_056464.1	IRF-2BP1_2	8..59	CDD:463250	40/50 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..127		22/111 (20%)
		PRK12323	<342..>463	CDD:481241	40/170 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..420		21/91 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..495		24/117 (21%)
		RING_Ubox	500..561	CDD:473075	46/82 (56%)
		Cys-rich	503..550		38/47 (81%)