DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pits and St18

DIOPT Version :9

Sequence 1:	NP_001138192.1	Gene:	Pits / 32205	FlyBaseID:	FBgn0030400	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_030109815.1	Gene:	St18 / 240690	MGIID:	2446700	Length:	1052	Species:	Mus musculus

Alignment Length:	927	Identity:	171/927 - (18%)
Similarity:	244/927 - (26%)	Gaps:	403/927 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLQTKRQH-CYLCDLPRMPWAMINDF--------SEAVCRGCVNYEGA--DRIEAVLDAARQMKR 55
            |||.|.|: ||       |..|:...        ||:|...|.|..|:  ..::|..|.|.:...
Mouse   119 SLQKKDQYTCY-------PELMVKSLVHLGKFEESESVQTTCENLNGSSIQSLKAESDEAHEGSM 176

  Fly    56 LHPASKQQRSH-------------------ENG-----------EVSAAAAAAVVLQQQQQLQVG 90
            :|..:.:.:.|                   |||           :........:...::..|:|.
Mouse   177 VHSDNGRDKVHHSQPPFCSSGDSESDSDSAENGWGNGSNSSEDTDTHKGPKHKLTYNRKDLLEVP 241

  Fly    91 PVPGQG----PGSHR---GGGGGGP-------------PGAPPGSGGPG-----------PSGAG 124
            .:..:.    |..:|   ...|..|             |..|....|..           ....|
Mouse   242 EIKAEDDKFIPCENRCDSDTDGRDPQNSHMEPLVVKAQPSFPEVEEGESLATVTEEPAEVEKAKG 306

  Fly   125 SLSSLGNAVAAAAAAAAVHHH----------HQMPYQMPVPRIGPPLDYPVKLEDAPGGGV---- 175
            :||.|..|:|..|...:|.||          ..:..:...||:          .||.|..:
Mouse   307 NLSLLEQAIALQAERGSVFHHTYKELDRFFLDHLARERRQPRV----------TDANGRQIFTNK 361

  Fly   176 ---RPVR------------ISHMT---PHHLPPNATRGGGGAPGG---------------GVPTA 207
               ||.|            ..|:|   |||      |...|.|..               ..||.
Mouse   362 HSPRPERREAKCPIPGCDGTGHVTGLYPHH------RSLSGCPHKVRVPLEILAMHENVLKCPTP 420

  Fly   208 GSGGGSLPPALSVNLKRPPSEDVDVDVSQQQQQSGHGLAPDGSAGNSLSAGGGVSGGCP-PGIKR 271
            |..|                             .|| :..:.:...|||       ||| ...::
Mouse   421 GCTG-----------------------------RGH-VNSNRNTHRSLS-------GCPIAAAEK 448

  Fly   272 SAMD------DPSGVGGRPPLTRGESLPAAVSY------VPERQLSGLRDKQQPVRAP----SFD 320
            .||.      |.|..|..|......:|...:.:      :...:.|..:::::..:.|    |||
Mouse   449 LAMTQDKSQLDSSQTGQCPEQAHRVNLVKQIEFNFRSHAITSPRASASKEQEKFGKVPFDYASFD 513

  Fly   321 ASTFKAANPIPNPIPHHLHIAEHMSPASRRNGSSPPSGPLPPRSVHSPNSSGSSSGRRSSGSRHV 385
            |..| ...|:                  .:.|....:.|. |.|.|..|.....:|..|:|: |.
Mouse   514 AQVF-GKRPL------------------LQTGQGQKAPPF-PESKHFSNPVKFPNGLPSAGA-HT 557

  Fly   386 SSTTVTSSEVGGSNPGQAVVAGGLGGGGGGGPGSNAASGQLGGPSGGSGQLSCTSGGPGGSASSG 450
            .||...||...|.......:|              ||:..|...:.........|..|....:.|
Mouse   558 QSTVRASSYGHGQYSEDTHIA--------------AAAAILNLSTRCREATDILSNKPQSLRAKG 608

  Fly   451 S----GGNGAIGPASMAPN-----SVAGDGSPAGGNGPSGS--NGSGGSVN-------------- 490
            :    ..||.: ..||..|     |:....||.....||.|  |.|...||
Mouse   609 AEIEVDENGTL-DLSMKKNRIHDKSIPPTSSPTTITTPSSSPFNASSLLVNAAFYQALSDQEGWN 672

  Fly   491 ---------------------------------------------------------PGPGSSGS 498
                                                                     |.||..||
Mouse   673 VPINYSKSHGKTEEEKEKDPVNFLENLEEKKFAGEASIPSPKPKLHTRDLKKELITCPTPGCDGS 737

  Fly   499 QGGGG--------GGTPLASGG--------------GSAGSGGLGGAPGSSAASNSAAAAAAAAA 541
            ....|        .|.|||...              .:.|..|.|...|:.|:..|  .:....|
Mouse   738 GHVTGNYASHRSVSGCPLADKTLKSLMAANSQELKCPTPGCDGSGHVTGNYASHRS--LSGCPRA 800

  Fly   542 QNATLKCTLCQERLEDTHFVQCPSV------------NHHKFCFPCSRESIKRQ----------- 583
            :...:|.|..:|..||:. ::||.:            ..|:....|.. :.|||
Mouse   801 RKGGIKMTPTKEEKEDSE-LRCPVIGCDGQGHISGKYTSHRTASGCPL-AAKRQKENPLNGAPLS 863

  Fly   584 ----------------NGLG--NEVYCP----SGDRCPLANSVIPWAFMQGEITTI--------- 617
                            ||||  |.|:..    ||  |||....|....:..|:.||
Mouse   864 WKLNKQELPHCPLPGCNGLGHVNNVFVTHRSLSG--CPLNAQAIKKVKVSEELMTIKLKATGGID 926

  Fly   618 -------LGEEVKVKKE 627
                   |.||:|...|
Mouse   927 GDEEIRHLDEEIKELNE 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:288155	15/61 (25%)
Pits	NP_001138192.1	zf-C3HC4	548..593	CDD:278524	17/85 (20%)
St18	XP_030109815.1	zf-C2HC	372..398	CDD:396216	7/31 (23%)
		zf-C2HC	416..444	CDD:396216	12/64 (19%)
		MYT1	487..720	CDD:400668	45/268 (17%)
		zf-C2HC	728..756	CDD:396216	8/27 (30%)
		zf-C2HC	772..800	CDD:396216	6/29 (21%)
		zf-C2HC	820..848	CDD:396216	4/28 (14%)
		zf-C2HC	874..900	CDD:396216	9/27 (33%)
		Com_YlbF	928..1011	CDD:412922	5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848754
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930