DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pits and Myt1l

DIOPT Version :9

Sequence 1:	NP_001138192.1	Gene:	Pits / 32205	FlyBaseID:	FBgn0030400	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001348584.1	Gene:	Myt1l / 17933	MGIID:	1100511	Length:	1189	Species:	Mus musculus

Alignment Length:	375	Identity:	78/375 - (20%)
Similarity:	114/375 - (30%)	Gaps:	110/375 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 RQLSG----LRDKQQPVRAPSF--DAS-TFKAANPIPNP-----------IPHHLHIAEHMSPAS 348
            |||:|    .:.....|:.|.:  |.| |.|..:..|.|           .|||
Mouse   472 RQLAGEDRKSKSSDSHVKKPYYGKDPSRTEKRESKCPTPGCDGTGHVTGLYPHH----------- 525

  Fly   349 RRNGSSPPSGPLPPR--SVH-------SPNSSGS---SSGRRSSGSRHVSSTTVTSSE--VGGSN 399
            |.....|....:||.  ::|       :|..:|.   :|.|.|  .|.:|...:.::|  .....
Mouse   526 RSLSGCPHKDRVPPEILAMHENVLKCPTPGCTGRGHVNSNRNS--HRSLSGCPIAAAEKLAKAQE 588

  Fly   400 PGQAVVAGGLGGGGGGGPGSNAASGQLGGPSGGSGQLSCTSGG---------PGGSASS------ 449
            ..|:....          .||.||.::..|.....||.....|         |..:.:.
Mouse   589 KHQSCDVS----------KSNQASDRVLRPMCFVKQLEIPQYGYRNNVPTTTPRSNLAKELEKYS 643

  Fly   450 ------GSGGNGAIGPASMAPNSVAGDGSPAG---------GNGPSGSNGSGGSVNPGPGSSGSQ 499
                  .|..|...|..::||.....|.||.|         ...||.|..|    :..|.||.:
Mouse   644 KTSFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYCKNASPSSSTTS----SYAPSSSSN- 703

  Fly   500 GGGGGGTPLASGGGSAGSGGLGGAPGSSAASNSAAAAAAAAAQNATLKCTLCQERLEDTHFVQCP 564
                    |:.||||:.|.....:.........||..||.|..|.:.:|....:.|
Mouse   704 --------LSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNL--------- 751

  Fly   565 SVNHHKFCFPCSRESIKRQNG---LGNEVYCPSGDRCPLANSVIPWAFMQ 611
            |......|...:.:....:||   |......|....||:...:.|.:..|
Mouse   752 STKPQDLCTARNPDMEVDENGTLDLSMNKQRPRDSCCPVLTPLEPMSPQQ 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:288155
Pits	NP_001138192.1	zf-C3HC4	548..593	CDD:278524	7/47 (15%)
Myt1l	NP_001348584.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		zf-C2HC	30..58	CDD:366692
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..178
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..248
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..422
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..514		12/41 (29%)
		zf-C2HC	506..532	CDD:366692	6/36 (17%)
		zf-C2HC	550..578	CDD:366692	7/29 (24%)
		MYT1	622..873	CDD:369895	41/202 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	686..710		10/36 (28%)
		zf-C2HC	905..933	CDD:366692
		zf-C2HC	954..982	CDD:366692
		zf-C2HC	1007..1035	CDD:366692
		SH3_and_anchor	<1061..>1139	CDD:275056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930