Protein Alignment Pits and irf2bpl

DIOPT Version :10

• Sequence 1: NP_001138192.1
• Gene: Pits / 32205
• FlyBaseID: FBgn0030400
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_001123823.1
• Gene: irf2bpl / 100170574
• XenbaseID: XB-GENE-968642
• Length: 690
• Species: Xenopus tropicalis
• Alignment Length: 757
• Identity: 234/757 - (30%)
• Similarity: 295/757 - (38%)
• Gaps: 208/757 - (27%)

  Fly     5 TKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLH------------ 57
            ::||.||||||||||||||.||:|.|||||||||||||||.|:|.|||:||.|
 Frog     9 SRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRIEFVIDTARQLKRSHSFQDGRSPGPQG 73

  Fly    58 ----PASKQ--------------QRSHENGEVSAAAAAAVVLQQQQQLQVGPVPGQGPGSHRG-- 102
                .|:||              |.:|.:|...||||:.             :...|..:.||
 Frog    74 PGSGAANKQHPAVQAALTAKDTAQLNHLDGATKAAAASG-------------LERYGLATDRGRF 125

  Fly   103 ---------GGGGGPPGAPPGSGGPGPSGAGSLSSLGNAVAAAAAAAAVHHHHQMPYQMPVPRIG 158
                     .|..|.|  .||..||......|.:|.|..           .|..:|..:|.....
 Frog   126 EYTLTARLPNGLNGFP--KPGEDGPPELNRQSPNSRGRT-----------GHGLIPQLVPGQLSV 177

  Fly   159 PPLDYPVKLEDAPGGGVRPVRISHMTPHHLPPNATRGGGGAPGGGVPTAGSGGGSLPPALSVNLK 223
            ||...|..|.:.|..|         ||...|....||...:.|..||...|..|        :.|
 Frog   178 PPNLLPQTLLNGPPSG---------TPSGAPHVLGRGPASSSGLSVPPTASSSG--------DPK 225

  Fly   224 RP---PSEDVDVDVSQQQQQSGHGLAPDGSAGNSLSAGGGVSGGCPPGIKRSAMDDPSGVGGRPP 285
            ||   .|.|.:.::.::|:.|........|..|......|     .|...|.|:
 Frog   226 RPGSVSSTDQERELKEKQRNSEALSELTESLRNRAEEWAG-----KPKAVRDAL----------- 274

  Fly   286 LTRGESLPAAVSYVPERQLSGLRDKQQPVRAPSFDASTFKAANPIPNPIPHHLHI-AEHMSPASR 349
            ||.....|..|.:..:..|.|        |..:|||::      .|..:.:.|.: .|:  |:..
 Frog   275 LTLSACTPFDVRFKKDHNLLG--------RVFAFDAAS------KPGLLDYELKLFVEY--PSGL 323

  Fly   350 RNGSSPPSGPLPP--RSVHSPNSSGSSSG--------RRSSGSRHVSSTTVTSS-----EVGGS- 398
            .|..|..||....  :........|.|||        :..||...:....:..|     |:.|:
 Frog   324 LNVFSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLLPESVRFFKEMVGAD 388

  Fly   399 -------NPG---------------QAVVAGGLGGGGGG-----------GPGSNAASGQ--LGG 428
                   :||               .|..|.....||.|           .|..::|.||  :.|
 Frog   389 MLPQPYLDPGCPMLPSALVNLPRALAAAAAASSSAGGSGQARSGVRKRKPSPEPDSADGQMWITG 453

  Fly   429 PSGGSGQLSCTSGGPGGSASSGSGGNGAIGPASMAPNSVAGDGSP--AGGNGPSGSNGSGGSVNP 491
            ...|..|||..:.|...|:||.:.|..::.|..:.|........|  |..||||.........:.
 Frog   454 QPDGIKQLSMAAAGGTPSSSSAAYGVPSVPPPPLGPGHPQRTTPPESAPPNGPSPMAALQSVTDT 518

  Fly   492 -GPGSSGSQGGGGGGTPLASGGGSA--------------GSGGLGGAPGSSAASNSAAAAAAAAA 541
             |...|...|..||..|:.|...||              |...|....|:.:|..|...|.|..|
 Frog   519 LGTAHSPKDGQTGGVPPVHSTTSSARRNSSSPVSPASVTGQRRLNSRNGAGSADLSLQVAPAGGA 583

  Fly   542 ----------QN---------ATLKCTLCQERLEDTHFVQCPSVNHHKFCFPCSRESIKRQNGLG 587
                      ||         ..|.||:|.||||||||||||||..|||||||||:|||.|...|
 Frog   584 PHPGMDQVHPQNIPDSPMANSGPLCCTICHERLEDTHFVQCPSVPSHKFCFPCSRDSIKAQGATG 648

  Fly   588 NEVYCPSGDRCPLANSVIPWAFMQGEITTILGEEVKVKKERE 629
             |||||||::|||..|.:|||||||||.|||..:|||||||:
 Frog   649 -EVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERD 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:463250	41/50 (82%)
		vRING-HC_IRF2BP1-like	546..602	CDD:438174	42/55 (76%)
irf2bpl	NP_001123823.1	IRF-2BP1_2	10..61	CDD:463250	41/50 (82%)
		vRING-HC_IRF2BPL	602..667	CDD:438377	43/65 (66%)