Protein Alignment hwt and Shf

DIOPT Version :10

• Sequence 1: NP_001259484.1
• Gene: hwt / 32202
• FlyBaseID: FBgn0264542
• Length: 1768
• Species: Drosophila melanogaster
• Sequence 2: NP_001360940.1
• Gene: Shf / 435684
• MGIID: 3613669
• Length: 483
• Species: Mus musculus
• Alignment Length: 584
• Identity: 161/584 - (27%)
• Similarity: 219/584 - (37%)
• Gaps: 179/584 - (30%)

  Fly  1247 AQGHQGGQSTHHHHHHHHHAP-GSRRNRHGQSQGQTTGGGHNYSSTESIATSSSGGSMESLRSST 1310
            |||..||            .| ||||...|...|  .|||            .|||..:.||
Mouse    17 AQGSAGG------------GPGGSRRGAGGAGTG--PGGG------------GSGGVAKWLR--- 52

  Fly  1311 SEGNRSTSSSESRHSSSLSSHSSESGSGGSGGSGGSSVAYPLRPAPLLLHSKLHILSPISDKSSQ 1375
                               .|....|.||.||:         :|||           |..|....
Mouse    53 -------------------EHLGFRGGGGGGGA---------KPAP-----------PEPDYRPP 78

  Fly  1376 EPASASASEQSQQPSQQLAPMASQED---DSTTSGAPAGNQVQVNASLKQPR-------SNRGAP 1430
            .|..|:   ....|...||....|.|   :...||.|:     .:|:|..|.       ...|:|
Mouse    79 APCPAA---PPAPPPDILAAYRLQRDRDFEDPYSGGPS-----ASAALSTPAVPGPTPPPRHGSP 135

  Fly  1431 NKALLQLADELLG-----SDSGISLHSREDGKPQALALQRLTLPKLQLIGAEGTTTSATASGAGG 1490
            ...|:::  |..|     .|||          |.| :..||.:.:..   |:......|..|:||
Mouse   136 PHRLIRV--ETPGPPAPPPDSG----------PPA-SSDRLAILEDY---ADPFDVQETGEGSGG 184

  Fly  1491 SSATGGSSGAGGSGSG------------SVVASGSTGIQQ-DLRDLPFDMPKLRRRKTLQQEAAC 1542
               |.|:.|......|            .:..|..|..|. .|.|.|::.         :.|.|.
Mouse   185 ---TSGAPGKVPENDGYMEPYEAQKMMAEIRGSKETAAQPLPLYDTPYEP---------EDEGAS 237

  Fly  1543 TSGSATS-------VDLGELP---FDMP---KLRRRLRANQAEINNLLMHSTESSGISQASSSHS 1594
            ..|..|.       .:..|.|   :|.|   |..|..:|...:| .::........:.|..||.|
Mouse   238 PEGEGTPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDI-KVIKDLPWPPPVGQLDSSPS 301

  Fly  1595 MRDDQKMSSKLDTALFRQNLTLNLNESRQATKQF-GS-----------------LDLRGLNSNKE 1641
            :.|..:..|...:.|...:|       ..::.|| ||                 |......|.|.
Mouse   302 LPDGDRDISGPASPLPEPSL-------EDSSAQFEGSENCLSPGREEKGRLPPRLSAGNPKSAKP 359

  Fly  1642 LNMNLSQ--GYVTAVDLIDVTIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSL 1704
            |.|..|.  |..|     |..:|||.|.||||||:|.:||..||...|.|:||||.|::|.|:||
Mouse   360 LGMEPSSPLGEWT-----DPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSL 419

  Fly  1705 SLKGAKGFMHMRIQRNETGQYILGQFSRPFETVPEMIRHFCLNRLPVRGAEHMCLIEPVIAQLL 1768
            |||.::|||||::.|.:..:|:|||.|.||.:|||::.|:...:||::|||||.|:.||..:.|
Mouse   420 SLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hwt	NP_001259484.1	SH2_SHB_SHD_SHE_SHF_like	1666..1763	CDD:198198	51/96 (53%)
Shf	NP_001360940.1	SH2_SHF	381..478	CDD:198255	51/96 (53%)