Protein Alignment hwt and Shb

DIOPT Version :10

• Sequence 1: NP_001259484.1
• Gene: hwt / 32202
• FlyBaseID: FBgn0264542
• Length: 1768
• Species: Drosophila melanogaster
• Sequence 2: NP_001028478.1
• Gene: Shb / 230126
• MGIID: 98294
• Length: 503
• Species: Mus musculus
• Alignment Length: 573
• Identity: 145/573 - (25%)
• Similarity: 227/573 - (39%)
• Gaps: 175/573 - (30%)

  Fly  1268 GSRRNRHGQSQGQTTGGGHNYSSTESIATSSSGGSMESLRSSTSEGNRSTSSSESRH-------- 1324
            |.||.:..|:..|..........:.:...|:|.||:.....|||:..|:..:.:.|.
Mouse    34 GERREQPPQAVPQACSASSASCGSAAACFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGP 98

  Fly  1325 SSSLSS-----HSSESGSGGSGGSGGSSVAYPLRPAPLLLHSKLHILSPISDKSSQEPASASASE 1384
            .|||..     .....|.||.|..||...|:                          .|:|.|
Mouse    99 GSSLRKLRAMCRLDYCGGGGGGDPGGGQRAF--------------------------TAAAGA-- 135

  Fly  1385 QSQQPSQQLAPMASQEDDSTTSG---APAGNQVQVNASLKQPRSNRGAPNKALLQLADELLGSDS 1446
                                 :|   |.||.....::|     |:.|:|:
Mouse   136 ---------------------AGCCCAAAGAGAAASSS-----SSSGSPH--------------- 159

  Fly  1447 GISLHSREDGKPQALALQRLTLPKLQLIGAEGTTTSATASG-AGGSSATGGSSGA----GGSGSG 1506
              ...|..:.:|...|..|...||.:||..|    ||:|:| ..|...:||.:.:    ||....
Mouse   160 --LYRSSSERRPTTPAEVRYISPKHRLIKVE----SASAAGDPPGGVCSGGRTWSPTTCGGKKLL 218

  Fly  1507 SVVASGSTG--------IQQDLRDLPFDMPKLRRRKTLQQEAACTSGSATSVDLGELPFDMPKLR 1563
            :..::..||        |..|..| |||     .:..|:.:|    |...|....| |::..::.
Mouse   219 NKCSAEETGAGQKDKVTIADDYSD-PFD-----AKSDLKSKA----GKGESAGYME-PYEAQRIM 272

  Fly  1564 ---RRLRANQAEINNLLMHST--ESSGISQASSSHSM-----------RDDQKMSSKLDTALFRQ 1612
               :|..:.:::...:.::.|  |..|.|..|.|.|.           :||.:.:.:.|......
Mouse   273 TEFQRQESVRSQHKGIQLYDTPYEPEGQSVDSDSESTVSLRLRESKLPQDDDRPADEYDQPWEWN 337

  Fly  1613 NLTL-------NLNESRQATK--------------------QFGSLDLRGLNSNKELNMNLSQGY 1650
            .:|:       |.||.||::.                    :.||.:..|:...:
Mouse   338 RVTIPALAAQFNGNEKRQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGER---------- 392

  Fly  1651 VTAVDLIDVTIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFMHM 1715
                  :|.|||||:|.||||||:|.:||..||...|.|:||||.:::|.|||||||..:|||||
Mouse   393 ------VDPTIPLEKQIWYHGAISRSDAENLLRLCKECSYLVRNSQTSKHDYSLSLKSNQGFMHM 451

  Fly  1716 RIQRNETGQYILGQFSRPFETVPEMIRHFCLNRLPVRGAEHMCLIEPVIAQLL 1768
            ::.:.:. :|:|||.|.||::|||:|.::...:||::||||:.|:.||..:.|
Mouse   452 KLAKTKE-KYVLGQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPVAVRTL 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hwt	NP_001259484.1	SH2_SHB_SHD_SHE_SHF_like	1666..1763	CDD:198198	49/96 (51%)
Shb	NP_001028478.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		5/14 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..81		7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..180		8/54 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..262		12/46 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	292..333		10/40 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	345..381		5/35 (14%)
		SH2_SHB	402..498	CDD:198252	49/96 (51%)