DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hwt and SHE

DIOPT Version :9

Sequence 1:	NP_001259484.1	Gene:	hwt / 32202	FlyBaseID:	FBgn0264542	Length:	1768	Species:	Drosophila melanogaster
Sequence 2:	NP_001010846.1	Gene:	SHE / 126669	HGNCID:	27004	Length:	495	Species:	Homo sapiens

Alignment Length:	666	Identity:	144/666 - (21%)
Similarity:	231/666 - (34%)	Gaps:	199/666 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1127 YTPSPPSTAPLPMKFPGKHDRYLNMNSIRSAPNLPAANPAHPRL-----RDLRLPIQSMRHQC-- 1184
            ::|:|.::|.|         .:.:..:..:||.|.......|.:     ::..|.::::..:.
Human     3 WSPTPGASACL---------GWASSLACSTAPTLLGRAGRGPLMAAKWFKEFPLNLKTVSERAKP 58

  Fly  1185 ---GGSSNDNSLTDSAYVNPPSTNSNSNAASASASASVSATGSAAPRRPRSFVLESGRVLELRRS 1246
               ||....||....|...|.....||.|...|..|.|....|...|.....::::.       :
Human    59 GGGGGKLRKNSEAGGAGPGPGKGRKNSAAELGSGRAGVGPKDSRLSRDSLQGLIQAA-------A 116

  Fly  1247 AQGHQGGQSTHHHHHHHHHAPGSRRNRHGQSQGQTTGGGHNYSSTESIATSSSGGSM---ESLRS 1308
            .:|.:..::|....|..                               ||.|||.|.   ..::.
Human   117 GKGRKNSRATEEEPHRG-------------------------------ATKSSGCSTYINRLIKV 150

  Fly  1309 STSEGNRSTSSSESRHSSSLSSHSSESGSGGSGGSGGSSVAYPLRPAPLLLHSKLHILSPISDKS 1373
            .|.|.|     .:|.:.||.||.||.|.|..|..|.                     |.|..||.
Human   151 DTQEKN-----GKSNYPSSSSSSSSSSSSASSSPSS---------------------LGPELDKG 189

  Fly  1374 SQEPASASASEQSQQPSQQLAPMASQEDDSTTSGAPAGNQVQVNASLKQPRSNRGAPNKALLQLA 1438
            .        ..:.|:....|...|...|...|.|.....:|..|....:|..            |
Human   190 K--------IIKQQETVIILEDYADPYDAKRTKGQRDAERVGENDGYMEPYD------------A 234

  Fly  1439 DELLGSDSGISLHSREDGKPQALALQRLTLPKLQLIGAEGTTTSATASGAGGSSATGGSSGAGGS 1503
            .:::     ..:..|....|...|||.|..|   ...|:|...|.|.:....|
Human   235 QQMI-----TEIRRRGSKDPLVKALQLLDSP---CEPADGGLKSETLAKRRSS------------ 279

  Fly  1504 GSGSVVASGSTGIQQDLRDLPFDMPKLRRRKTLQQEAACTSGSATSVDLGELP---------FDM 1559
                   ....|....|.|.|::..:...|         ..|.|...| ..||         ::.
Human   280 -------KDLLGKPPQLYDTPYEPAEGGPR---------AEGKARPPD-SRLPENDERPAAEYEQ 327

  Fly  1560 P---KLRRRLRANQAEINNLLMHSTESSGISQASSSHSMRDDQKMSSKLDTALFRQNLTLNLNES 1621
            |   |..:.:||          .|.:..|..:.|                   ||:......:..
Human   328 PWEWKKEQIVRA----------LSVQFEGAERPS-------------------FREETVRQHHRQ 363

  Fly  1622 RQATKQFGSLDLRGLNSNKELNMNLSQGYVTAVDLIDVTIPLERQGWYHGAITRIEAETTLRPLS 1686
            :..|::.    |:...|:.      |:|     :.:|..:|||:|.||||||:|.|||:.|:|..
Human   364 KSWTQKI----LKPALSDH------SEG-----EKVDPGLPLEKQPWYHGAISRAEAESRLQPCK 413

  Fly  1687 EGSFLVRNCESTKQDYSLSLKGAKGFMHMRIQRNETGQYILGQFSRPFETVPEMIRHFCLNRLPV 1751
            |..:||||.||....||::||.::|.:|:.:.:.:..:|.|.|.|..|:::||::.::...:||.
Human   414 EAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLPF 478

  Fly  1752 RGAEHMCLIEPVIAQL 1767
            :|||||.|:.||.::|
Human   479 KGAEHMTLLYPVHSKL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hwt	NP_001259484.1	SH2_SHB_SHD_SHE_SHF_like	1666..1763	CDD:198198	41/96 (43%)
SHE	NP_001010846.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..190		41/202 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..233		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..327		17/102 (17%)
		SH2_SHE	393..490	CDD:198254	41/96 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M87
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001120
OrthoInspector	1	1.000	-	-		otm40496
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.870