DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lsp1alpha and Lsp2

DIOPT Version :9

Sequence 1:	NP_511138.2	Gene:	Lsp1alpha / 32199	FlyBaseID:	FBgn0002562	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_001287042.1	Gene:	Lsp2 / 45326	FlyBaseID:	FBgn0002565	Length:	701	Species:	Drosophila melanogaster

Alignment Length:	818	Identity:	273/818 - (33%)
Similarity:	406/818 - (49%)	Gaps:	145/818 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FAIAFLACVAVVTATAYHKTHDIKVADKAFLMKQKFLFEIVYRVEDPLMFEEYIAMGKQFYFDKE 67
            |.:..||.||::......|..|.|||||.|||||||:::|:..:....:|..........|...|
  Fly     4 FTVIALAAVALLATLGQAKHLDSKVADKDFLMKQKFMYQILQHIYQDDVFTTPFGGSYVEYKPWE 68

  Fly    68 H---YTHFDLYMEKFFEAHKAHALLPKGEFFGALVKHHAKQARGLFNFFYYAKDWETFMTNVAFA 129
            |   |.|.:: :|.|||..: |........:..:...|.:...||...||:||:||||...|.:|
  Fly    69 HVADYVHPEM-LEHFFELWQ-HQPFTDDMVWSVMYDKHEEYVVGLVRLFYFAKNWETFQHVVYWA 131

  Fly   130 RMHFNEGMFVYALTLAVIHRDDFHGLVLPAIHEIFPQFFFNSKFVMEAEKFDYEMWMKTSLYEKE 194
            |.|.|:.:||||:|:|.:.|||..|:||||.:||.|..:|:|:.:..||  .|:|
  Fly   132 RQHVNKQLFVYAVTIASLFRDDMQGVVLPAHYEIHPWSYFDSQALEWAE--HYKM---------- 184

  Fly   195 YMDVYHKIPTFSSYEHGYKQGMAYGYGKTHGHGQTYEHEFGSMYQTSDYMYMKDFKTWQWWKLMG 259
                           ||:                   |....|    |.:|
  Fly   185 ---------------HGF-------------------HHVKQM----DNIY-------------- 197

  Fly   260 LGEHWYSESNYILRENIYEYNQESNWLTMMKDVKKFYMPVDYSRDLYLYNEESKLSYFTEDLGWN 324
                     |.::|.|                         ||......|.:..|:|:.||:|:|
  Fly   198 ---------NVVIRTN-------------------------YSNVHGSLNYDHDLAYYLEDVGFN 228

  Fly   325 SYWYYLNMDYSFFL-DGKTFGLQNDRRGEWWLYNVHQLLSRYHMERLSHGLGEIPQFSWFHQIEM 388
            :::||.|:||.|:. .|:...|..|||||.:||...|||:|:::|||||.|||:|.|:.:...|.
  Fly   229 AFYYYFNLDYPFWTKGGEEHVLNKDRRGELYLYVHWQLLARWYLERLSHDLGEVPAFNMYVPTES 293

  Fly   389 GYDPQLIYYNGIGYSYRKNYYELETYGNFEMLDKITGFQQRIQNIVELGYYQTTDGHMIDLRKPE 453
            ||...|..|.|:...:|:|::......|:|.::.:..:.||:.:.:          |..:....|
  Fly   294 GYASNLRTYYGVPQWHRENHHSFYHEHNYEHIEHVEMYTQRVMDWI----------HKNEKFDVE 348

  Fly   454 SIEIIGNMLQGNVDAIDNIFFQFWYMLAHMYFADTHYYQM--EVYPNVMLNFETMMRDPMFYMFY 516
            :|.::||::|||.|::|..|:.....|......:.|:|..  |.:|.:.::::|.||||:||..|
  Fly   349 TINVLGNIIQGNADSVDKKFYGSLDKLYRFIVNEGHHYGHGDESFPGLFMHYDTSMRDPIFYEVY 413

  Fly   517 KSIAQVYFQFMHHLPKYTKEQLLMPGVTLKHVEVSE-LVTYFDLVDFDVTNMLN----------- 569
            |:|...|:..|...|:|.|:.....||.:..|.:.| |.|||:..|.|::|.:|
  Fly   414 KTIVSHYWHLMETYPEYHKKDYAFEGVHIDAVHMPESLTTYFEHFDSDISNAVNVEPAVEGSADP 478

  Fly   570 ----GKMVFHEGQFLWDKSLFARQMRLNHKPFSYTYTIDSARDEKVVIRAFLGPKFDEYGRMISL 630
                |:...::|.....|   |||.|||||||.:|..:.|.:.:..|::.|:|||:||:|..|.|
  Fly   479 LYTFGRNSHYKGSSYVIK---ARQQRLNHKPFEFTLDVTSDKAQDAVVKVFIGPKYDEHGHEIPL 540

  Fly   631 TDNRMNFMEIDEFTYTLKTGSNLITRKSTDFAWTVKDRTTYTELYYYTMMAFDGKYDYPLDLTEP 695
            ..|..||.|::.|...|:.|.|.|.|.|.||::.|.|||||.|||...|.|.:..|.:.||.:|.
  Fly   541 EHNYQNFFELEHFKVHLEAGVNHIKRASGDFSFWVNDRTTYLELYQKLMDATNSDYKFKLDQSEA 605

  Fly   696 HCGFPDRLVLPMGWKKGMPMQMFFMVVPYMAPQHEQFSTFDYTYSCGIGSGARHVDSLPFGYPFD 760
            |||.|:|::||.|.|.|...|.|:||.||..|:..||:.:|...|||:|.|:|:||:||||:||:
  Fly   606 HCGVPNRMMLPRGKKGGQVFQFFYMVYPYHQPEVAQFTGYDPVVSCGVGHGSRYVDALPFGFPFN 670

  Fly   761 REI-NEYEFHVPNMYFKDVTIYHADTMEKYYNYKEYTN 797
            |.: ::|.|.|.|..|.||.|:|.|         |:||
  Fly   671 RPVKHDYYFDVHNFKFVDVKIFHRD---------EHTN 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lsp1alpha	NP_511138.2	Hemocyanin_N	32..154	CDD:281684	44/124 (35%)
		Hemocyanin_M	287..523	CDD:278784	76/238 (32%)
		Hemocyanin_C	532..782	CDD:281685	110/266 (41%)
Lsp2	NP_001287042.1	Hemocyanin_N	33..156	CDD:281684	44/124 (35%)
		Hemocyanin_M	163..420	CDD:278784	94/364 (26%)
		Hemocyanin_C	430..693	CDD:281685	110/265 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470637
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28IXN
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27073
OrthoDB	1	1.010	-	-		D130404at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11511
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3797
	7	6.860