DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rab40 and RAB13

DIOPT Version :9

Sequence 1:NP_727611.1 Gene:Rab40 / 32195 FlyBaseID:FBgn0030391 Length:265 Species:Drosophila melanogaster
Sequence 2:NP_002861.1 Gene:RAB13 / 5872 HGNCID:9762 Length:203 Species:Homo sapiens


Alignment Length:251 Identity:86/251 - (34%)
Similarity:128/251 - (50%) Gaps:54/251 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 MTKDYDYLLKVLLVGDSDVGKHEILSNLEDPSTESPFCS--GNDCTSHILQTVAYKTTTILLEGK 66
            |.|.||:|.|:||:|||.|||..::....:.:..:.:.|  |.|          :|..|:.:|||
Human     1 MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDNFNNTYISTIGID----------FKIRTVDIEGK 55

  Fly    67 RVKLQLWDTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEVDEHA-PGIPKVLVG 130
            ::|||:|||:||.||.||..:|.|||.|||||||||::.||:.|..|:|.:.|:| .|:.::|:|
Human    56 KIKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNWMKSIKENASAGVERLLLG 120

  Fly   131 NRLHLAFKRQVAAKQAETYASRNNMSCFEISPLCNFNIRESFCELARMALHRNGMEHIWRSNKVL 195
            |:..:..||:|..:||:..|..:.:..||.|...:.|:.|:|..|||..|.::|.......||  
Human   121 NKCDMEAKRKVQKEQADKLAREHGIRFFETSAKSSMNVDEAFSSLARDILLKSGGRRSGNGNK-- 183

  Fly   196 SLQELCCRTIVRRTSVYAIDSLPLPPSVKSTLKSYALTTSQCFNSLTQSSKSKNRC 251
                                    |||  :.||             |...|:.|:|
Human   184 ------------------------PPS--TDLK-------------TCDKKNTNKC 200

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rab40NP_727611.1 P-loop_NTPase 6..265 CDD:304359 85/249 (34%)
RAB 12..182 CDD:197555 69/172 (40%)
SOCS 192..234 CDD:295349 7/41 (17%)
RAB13NP_002861.1 Rab8_Rab10_Rab13_like 6..172 CDD:206659 71/175 (41%)
Effector region. /evidence=ECO:0000250 37..45 3/17 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 173..203 12/69 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0078
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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