DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab40 and rab8a

DIOPT Version :9

Sequence 1:	NP_727611.1	Gene:	Rab40 / 32195	FlyBaseID:	FBgn0030391	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_001083031.1	Gene:	rab8a / 571897	ZFINID:	ZDB-GENE-070424-36	Length:	207	Species:	Danio rerio

Alignment Length:	177	Identity:	77/177 - (43%)
Similarity:	106/177 - (59%)	Gaps:	13/177 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MTKDYDYLLKVLLVGDSDVGKHEILSNLEDPSTESPFCS--GNDCTSHILQTVAYKTTTILLEGK 66
            |.|.||||.|:||:|||.|||..:|....:.:..|.|.|  |.|          :|..||.|:||
Zfish     1 MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGID----------FKIRTIELDGK 55

  Fly    67 RVKLQLWDTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEVDEHAPG-IPKVLVG 130
            ::|||:|||:||.||.||..:|.|||.||:|||||||:.|||.|..|::.::|||.. :.|:::|
Zfish    56 KIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNWIRNIEEHASADVEKMILG 120

  Fly   131 NRLHLAFKRQVAAKQAETYASRNNMSCFEISPLCNFNIRESFCELAR 177
            |:..:..||||:..:.|..|....:...|.|...|.|:..:|..|||
Zfish   121 NKCDINEKRQVSKDRGEKLALEYGIKFMETSAKANINVENAFLTLAR 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab40	NP_727611.1	P-loop_NTPase	6..265	CDD:304359	76/175 (43%)
		RAB	12..182	CDD:197555	71/169 (42%)
		SOCS	192..234	CDD:295349
rab8a	NP_001083031.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	74/172 (43%)
rab8a	NP_001083031.1	RAB	9..172	CDD:197555	71/169 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910