DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab40 and rasef

DIOPT Version :9

Sequence 1:	NP_727611.1	Gene:	Rab40 / 32195	FlyBaseID:	FBgn0030391	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	XP_699335.4	Gene:	rasef / 570731	ZFINID:	ZDB-GENE-081105-157	Length:	706	Species:	Danio rerio

Alignment Length:	176	Identity:	61/176 - (34%)
Similarity:	90/176 - (51%)	Gaps:	23/176 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KVLLVGDSDVGKHEILSNLEDPSTESPFCSGNDCTSHILQTVAYKTTTILLEGKRVKLQLWDTSG 77
            :::|.||:.|||...|..|    .::.| .||  ||..| .|.::..|::::|....||||||:|
Zfish   509 RIVLAGDAAVGKSSFLLRL----CKNEF-KGN--TSATL-GVDFQMKTLVVDGVPTVLQLWDTAG 565

  Fly    78 QGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEV-DEHAPGIPKVLVGNRLHL------ 135
            |.||.:|.:||.|.|.|::|:||:|.:.||..:..|:..: |.....||.:||||:..|
Zfish   566 QERFRSIAKSYFRRADGVLLLYDVTCEKSFLNVREWVDIIEDVSQDDIPIMLVGNKTDLRKEALQ 630

  Fly   136 ----AFKRQVAAKQAETYASRNNMSCFEISPLCNFNIRESFCELAR 177
                ........|.|.||::   :.| |.|.....||.|:...|||
Zfish   631 DGVTCIPTSYGEKLAMTYSA---LFC-ETSAKDGSNIIEAVLHLAR 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab40	NP_727611.1	P-loop_NTPase	6..265	CDD:304359	61/176 (35%)
		RAB	12..182	CDD:197555	61/176 (35%)
		SOCS	192..234	CDD:295349
rasef	XP_699335.4	EFh	9..69	CDD:238008
		EF-hand_7	10..68	CDD:290234
		DUF904	201..>253	CDD:283624
		RAB	508..674	CDD:197555	61/176 (35%)
		Rab	508..672	CDD:206640	59/174 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900