DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab40 and Rab44

DIOPT Version :9

Sequence 1:	NP_727611.1	Gene:	Rab40 / 32195	FlyBaseID:	FBgn0030391	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_001351777.1	Gene:	Rab44 / 442827	MGIID:	3045302	Length:	973	Species:	Mus musculus

Alignment Length:	177	Identity:	60/177 - (33%)
Similarity:	89/177 - (50%)	Gaps:	9/177 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GTMTKDYDYLLKVLLVGDSDVGKHEILSNLEDPSTESPFCSGNDCTSHILQTVAYKTTTILLEGK 66
            |....|.|||..|:.:|||:|||...|..|.    ...|.:|...|    ..|.::...:|::.|
Mouse   776 GKPQADPDYLYHVVFLGDSNVGKTSFLHLLH----HDAFATGLTAT----VGVDFRVKNLLVDNK 832

  Fly    67 RVKLQLWDTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEV-DEHAPGIPKVLVG 130
            ...||||||:||.|:.::.|...|.|:|::|:||:|::.||..:..||..: |....|:..||:|
Mouse   833 TFALQLWDTAGQERYHSLTRQLLRKAEGVVLMYDVTSQESFTHVRYWLDCLQDAGVEGVAMVLLG 897

  Fly   131 NRLHLAFKRQVAAKQAETYASRNNMSCFEISPLCNFNIRESFCELAR 177
            |::....:|||..:.....|....:|..|.|.....||.|....|||
Mouse   898 NKMDCEEERQVPTEAGRRLAQELGVSFGECSAALGHNILEPMMNLAR 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab40	NP_727611.1	P-loop_NTPase	6..265	CDD:304359	59/173 (34%)
		RAB	12..182	CDD:197555	55/167 (33%)
		SOCS	192..234	CDD:295349
Rab44	NP_001351777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		EF-hand_7	45..101	CDD:372618
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..140
		SMC_prok_B	<173..353	CDD:274008
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..481
		PHA03247	<425..783	CDD:223021	2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..708
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..779		1/2 (50%)
		Rab	788..944	CDD:206640	53/163 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900