DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab40 and Rab40c

DIOPT Version :9

Sequence 1:	NP_727611.1	Gene:	Rab40 / 32195	FlyBaseID:	FBgn0030391	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_872616.1	Gene:	Rab40c / 359728	RGDID:	727914	Length:	281	Species:	Rattus norvegicus

Alignment Length:	285	Identity:	164/285 - (57%)
Similarity:	203/285 - (71%)	Gaps:	29/285 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GTMTKDYDYLLKVLLVGDSDVGKHEILSNLEDPSTESPFCSGNDCTSHILQTVAYKTTTILLEGK 66
            |:..|.||||||.||||||||||.|||.:|:|.:.|||:...|.        :.||||||||:|:
  Rat     5 GSPVKSYDYLLKFLLVGDSDVGKGEILESLQDGAAESPYAYSNG--------IDYKTTTILLDGR 61

  Fly    67 RVKLQLWDTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEVDEHAPGIPKVLVGN 131
            ||||:|||||||||||||.||||||||||:|||||||:|||||||||:||:||||||:|::||||
  Rat    62 RVKLELWDTSGQGRFCTIFRSYSRGAQGILLVYDITNRWSFDGIDRWIKEIDEHAPGVPRILVGN 126

  Fly   132 RLHLAFKRQVAAKQAETYASRNNMSCFEISPLCNFNIRESFCELARMALHRNGMEHIWRSNKVLS 196
            ||||||||||..:||..||.:|.|:.||:|||||||:.|||.||:|:.|.|:|||.|||.|:|.|
  Rat   127 RLHLAFKRQVPTEQARAYAEKNCMTFFEVSPLCNFNVIESFTELSRIVLMRHGMEKIWRPNRVFS 191

  Fly   197 LQELCCRTIVRRTSVYAIDSLPLPPSVKSTLKSYALT---------------------TSQCFNS 240
            ||:||||.||..|.|:.||.||||.::||.|||:::.                     :....||
  Rat   192 LQDLCCRAIVSCTPVHLIDKLPLPVTIKSHLKSFSMANGMNAVMMHGRSYSLASGAGGSGSKGNS 256

  Fly   241 LTQSSKSKNRCKTPTSSSRNSCAIA 265
            |.:|...:.....|.:.||::|.|:
  Rat   257 LKRSKSIRPPQSPPQNCSRSNCKIS 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab40	NP_727611.1	P-loop_NTPase	6..265	CDD:304359	162/279 (58%)
		RAB	12..182	CDD:197555	118/169 (70%)
		SOCS	192..234	CDD:295349	24/62 (39%)
Rab40c	NP_872616.1	Rab40	9..281	CDD:133321	162/279 (58%)
Rab40c	NP_872616.1	SOCS_Rab40	187..229	CDD:239711	24/41 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	245	1.000	Domainoid score	I2113
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10907
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2395
OMA	1	1.010	-	-		QHG46774
OrthoDB	1	1.010	-	-		D1065856at2759
OrthoFinder	1	1.000	-	-		FOG0002583
OrthoInspector	1	1.000	-	-		otm46423
orthoMCL	1	0.900	-	-		OOG6_107740
Panther	1	1.100	-	-	LDO	PTHR47980
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1940
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840