DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab40 and Rab40b

DIOPT Version :9

Sequence 1:	NP_727611.1	Gene:	Rab40 / 32195	FlyBaseID:	FBgn0030391	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_001100546.1	Gene:	Rab40b / 303754	RGDID:	1305663	Length:	279	Species:	Rattus norvegicus

Alignment Length:	283	Identity:	159/283 - (56%)
Similarity:	209/283 - (73%)	Gaps:	26/283 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGTMTKDYDYLLKVLLVGDSDVGKHEILSNLEDPSTESPFCSGNDCTSHILQTVAYKTTTILLEG 65
            :|:..:.||:|||.||||||||||.|||::|:|.:.|||:  |:..      .:.:|||||||:|
  Rat     5 LGSPVRAYDFLLKFLLVGDSDVGKGEILASLQDGAAESPY--GHPA------GIDHKTTTILLDG 61

  Fly    66 KRVKLQLWDTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEVDEHAPGIPKVLVG 130
            :||||||||||||||||||.|||||||||:||||||.|:||||||:||:||:||||||:||:|||
  Rat    62 RRVKLQLWDTSGQGRFCTIFRSYSRGAQGVILVYDIANRWSFDGINRWIKEIDEHAPGVPKILVG 126

  Fly   131 NRLHLAFKRQVAAKQAETYASRNNMSCFEISPLCNFNIRESFCELARMALHRNGMEHIWRSNKVL 195
            |||||||||||..:||:.||.|..::.||:||||||||.|||.||||:.|.|:||:.:||.:|||
  Rat   127 NRLHLAFKRQVPTEQAQAYAERLGVTFFEVSPLCNFNITESFTELARIVLLRHGMDRLWRPSKVL 191

  Fly   196 SLQELCCRTIVRRTSVYAIDSLPLPPSVKSTLKSYALTT--------SQCFNSLTQSSKSKN--- 249
            |||:||||.:|..|.|:.:|.||||.:::|.|||:::..        .:.::....||..:|
  Rat   192 SLQDLCCRAVVSCTPVHLVDKLPLPVALRSHLKSFSMANGLNTRMMHGRSYSLTANSSHKRNSFR 256

  Fly   250 RCKT-------PTSSSRNSCAIA 265
            :.:|       |.:.:||||.|:
  Rat   257 KVRTIRPPQSPPRNCARNSCKIS 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab40	NP_727611.1	P-loop_NTPase	6..265	CDD:304359	157/276 (57%)
		RAB	12..182	CDD:197555	118/169 (70%)
		SOCS	192..234	CDD:295349	22/41 (54%)
Rab40b	NP_001100546.1	Rab40	10..279	CDD:133321	157/276 (57%)
Rab40b	NP_001100546.1	SOCS_Rab40	188..230	CDD:239711	22/41 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	245	1.000	Domainoid score	I2113
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2395
OMA	1	1.010	-	-		QHG46774
OrthoDB	1	1.010	-	-		D1065856at2759
OrthoFinder	1	1.000	-	-		FOG0002583
OrthoInspector	1	1.000	-	-		otm46423
orthoMCL	1	0.900	-	-		OOG6_107740
Panther	1	1.100	-	-	O	PTHR47980
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1940
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840