Protein Alignment Rab40 and RAB40AL

DIOPT Version :10

• Sequence 1: NP_727611.1
• Gene: Rab40 / 32195
• FlyBaseID: FBgn0030391
• Length: 265
• Species: Drosophila melanogaster
• Sequence 2: NP_001027004.1
• Gene: RAB40AL / 282808
• HGNCID: 25410
• Length: 278
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 161/284 - (56%)
• Similarity: 207/284 - (72%)
• Gaps: 30/284 - (10%)

  Fly     2 GTMTKDYDYLLKVLLVGDSDVGKHEILSNLEDPSTESPFCSGNDCTSHILQTVAYKTTTILLEGK 66
            |:..:.||:|||.|||||.||||.|||.:|:|.:.|||:       || |..:.||||||||:|:
Human     5 GSPDQAYDFLLKFLLVGDRDVGKSEILESLQDGTAESPY-------SH-LGGIDYKTTTILLDGQ 61

  Fly    67 RVKLQLWDTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEVDEHAPGIPKVLVGN 131
            ||||:|||||||||||||.|||||||||:||||||.|:|||:|:|||:|:::|||||:||:||||
Human    62 RVKLKLWDTSGQGRFCTIFRSYSRGAQGVILVYDIANRWSFEGMDRWIKKIEEHAPGVPKILVGN 126

  Fly   132 RLHLAFKRQVAAKQAETYASRNNMSCFEISPLCNFNIRESFCELARMALHRNGMEHIWRSNKVLS 196
            ||||||||||..:||:.||.|..::.||:||||||||.|||.||||:.|.|:.:..:.|.:||||
Human   127 RLHLAFKRQVPREQAQAYAERLGVTFFEVSPLCNFNIIESFTELARIVLLRHRLNWLGRPSKVLS 191

  Fly   197 LQELCCRTIVRRTSVYAIDSLPLPPSVKSTLKSYALTTSQCFN---------SLTQSS--KSKNR 250
            ||:|||||||..|.|:.:|.||||.:::|.|||:::  ::..|         |||.||  |..:.
Human   192 LQDLCCRTIVSCTPVHLVDKLPLPIALRSHLKSFSM--AKGLNARMMRGLSYSLTTSSTHKRSSL 254

  Fly   251 CKT---------PTSSSRNSCAIA 265
            ||.         |.:.:||||.|:
Human   255 CKVKIVCPPQSPPKNCTRNSCKIS 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab40	NP_727611.1	P-loop containing Nucleoside Triphosphate Hydrolases	6..265	CDD:476819	159/278 (57%)
		SOCS	192..234	CDD:470605	24/41 (59%)
RAB40AL	NP_001027004.1	P-loop containing Nucleoside Triphosphate Hydrolases	9..278	CDD:476819	159/278 (57%)
		Switch-I. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	41..49		5/15 (33%)
		Switch-II. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	72..88		14/15 (93%)
		SOCS_Rab40	187..228	CDD:239711	24/42 (57%)