DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rab40 and Rab12

DIOPT Version :9

Sequence 1:	NP_727611.1	Gene:	Rab40 / 32195	FlyBaseID:	FBgn0030391	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_037149.1	Gene:	Rab12 / 25530	RGDID:	3527	Length:	243	Species:	Rattus norvegicus

Alignment Length:	214	Identity:	78/214 - (36%)
Similarity:	120/214 - (56%)	Gaps:	29/214 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DYLLKVLLVGDSDVGKHEILSNLEDPSTESPFCSGNDCTSHILQTVAYKTTTILLEGKRVKLQLW 73
            |:.|:|:::|...|||    ::|.:..|:..||..  |.|.:  .|.:|..|:.|.||:::||:|
  Rat    39 DFKLQVIIIGSRGVGK----TSLMERFTDDTFCEA--CKSTV--GVDFKIKTVELRGKKIRLQIW 95

  Fly    74 DTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEVDEHA-PGIPKVLVGNRLHLAF 137
            ||:||.||.:|..:|.|.|:|||||||||.|.:||.:.:|:|.:|::| .....:||||:|....
  Rat    96 DTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCET 160

  Fly   138 KRQVAAKQAETYASR-NNMSCFEISPLCNFNIRESFCELARMALHRNGMEHIWR---SNKVLSLQ 198
            .|:::.:|.|.:|.: ..|...|.|...|||:.|.|.:|....|.:..:: :.|   ||.:||||
  Rat   161 DREISRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLD-VLRSELSNSILSLQ 224

  Fly   199 -------EL--------CC 202
                   ||        ||
  Rat   225 PEPEIPPELPPPRPHVRCC 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab40	NP_727611.1	P-loop_NTPase	6..265	CDD:304359	78/214 (36%)
		RAB	12..182	CDD:197555	66/171 (39%)
		SOCS	192..234	CDD:295349	9/26 (35%)
Rab12	NP_037149.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		Rab12	42..243	CDD:206699	75/209 (36%)
		Effector region. /evidence=ECO:0000250	70..78		3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900