DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab40 and Rab8a

DIOPT Version :9

Sequence 1:	NP_727611.1	Gene:	Rab40 / 32195	FlyBaseID:	FBgn0030391	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_446450.2	Gene:	Rab8a / 117103	RGDID:	621144	Length:	207	Species:	Rattus norvegicus

Alignment Length:	177	Identity:	78/177 - (44%)
Similarity:	107/177 - (60%)	Gaps:	13/177 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MTKDYDYLLKVLLVGDSDVGKHEILSNLEDPSTESPFCS--GNDCTSHILQTVAYKTTTILLEGK 66
            |.|.||||.|:||:|||.|||..:|....:.:..|.|.|  |.|          :|..||.|:||
  Rat     1 MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGID----------FKIRTIELDGK 55

  Fly    67 RVKLQLWDTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEVDEHAPG-IPKVLVG 130
            |:|||:|||:||.||.||..:|.|||.||:|||||||:.|||.|..|::.::|||.. :.|:::|
  Rat    56 RIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILG 120

  Fly   131 NRLHLAFKRQVAAKQAETYASRNNMSCFEISPLCNFNIRESFCELAR 177
            |:..:..||||:.::.|..|....:...|.|...|.|:..:|..|||
  Rat   121 NKCDVNDKRQVSKERGEKLALDYGIKFMETSAKANINVENAFFTLAR 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab40	NP_727611.1	P-loop_NTPase	6..265	CDD:304359	77/175 (44%)
		RAB	12..182	CDD:197555	72/169 (43%)
		SOCS	192..234	CDD:295349
Rab8a	NP_446450.2	Rab8_Rab10_Rab13_like	6..172	CDD:206659	75/172 (44%)
Rab8a	NP_446450.2	Effector region. /evidence=ECO:0000250	37..45		4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810