DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkcdelta and SCH9

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_012075.1	Gene:	SCH9 / 856612	SGDID:	S000001248	Length:	824	Species:	Saccharomyces cerevisiae

Alignment Length:	818	Identity:	220/818 - (26%)
Similarity:	349/818 - (42%)	Gaps:	210/818 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1195 SPNKQQALQLQQQHEEQQRQQQQQATNA------------SSPAATGD----------ATTTPTT 1237
            |.|:......|.||...|......::.|            |.|.|:.:          .|.||||
Yeast     9 SSNQDTGFSSQHQHPNGQNNGNNNSSTAGNDNGYPCKLVSSGPCASSNNGALFTNFTLQTATPTT 73

  Fly  1238 ITIGVAAVNVAAVAVVASAAAAAATDAAADATTSLSSNN------SCGEG---VGNNLSKFATVS 1293
                                 |.:.|..|..||.::|.|      |...|   |.||.|...|:.
Yeast    74 ---------------------AISQDLYAMGTTGITSENALFQMKSMNNGISSVNNNNSNTPTII 117

  Fly  1294 NLAQCLRDVDAELDDYIPSSAENSQEDDDDDDDGSGSSSDDYSSVDGCANLSASMKKKLRKEKKK 1358
            ..:|...:......|...:|.:||      :||...|||.....:...::||.:.:
Yeast   118 TTSQEETNAGNVHGDTGGNSLQNS------EDDNFSSSSTTKCLLSSTSSLSINQR--------- 167

  Fly  1359 QKAKAAAAAEAKRFD-PHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKREK-----IVYSDENT 1417
               :|||||.....| |..|:::                .:...|.|..|.|     :|.:.|::
Yeast   168 ---EAAAAAYGPDTDIPRGKLEV----------------TIIEARDLVTRSKDSQPYVVCTFESS 213

  Fly  1418 DDESGSEEGSGGSLDEDSDDESGGE---------ECSSTSSSASS------------------ED 1455
            :..|...| |.|:::.::::.:..:         ...:|:..|:|                  |.
Yeast   214 EFISNGPE-SLGAINNNNNNNNNNQHNQNQHINNNNENTNPDAASQHHNNNSGWNGSQLPSIKEH 277

  Fly  1456 LDAVAMVTKAGSSNATTVLDSSNSSGSNAGTLSVPS-----AGSGSGGGASTSSSPSI------- 1508
            |....:.|...||.    ||..||..|    ::.||     :.|||..|....||..|
Yeast   278 LKKKPLYTHRSSSQ----LDQLNSCSS----VTDPSKRSSNSSSGSSNGPKNDSSHPIWHHKTTF 334

  Fly  1509 ----------IRMSTCSNDSGFEG---------GTAPSS--------PKKMLET-------SYTY 1539
                      |.:...::|..|.|         ..|.:|        |:.:.|.       .:||
Yeast   335 DVLGSHSELDISVYDAAHDHMFLGQVRLYPMIHNLAHASQHQWHSLKPRVIDEVVSGDILIKWTY 399

  Fly  1540 SQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLE 1604
            .|.:|              ::|...||..|.:||||:||:|...:.:||...||:|.|.|.|:::
Yeast   400 KQTKK--------------RHYGPQDFEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVLSKKVIVK 450

  Fly  1605 DDDVDSTLIERKVL--ALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERA 1667
            .:::..|:.||.:|  ......|::..|..:|||.:.|:.|.:|::||:|.:|:|:.|||||:||
Yeast   451 KNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRA 515

  Fly  1668 RFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYM 1732
            :||.||::..|:.||...|:|||||.:|:|||..|::.:.|||:.|..: .|:| ::||||.:|:
Yeast   516 KFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNIALCDFGLSKADL-KDRT-NTFCGTTEYL 578

  Fly  1733 APEIIKGEK-YNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFP-VYISAEATGI 1795
            |||::..|. |.:.||:||.|||::||..|.|||...:..:::..|......|| ..:|.|....
Yeast   579 APELLLDETGYTKMVDFWSLGVLIFEMCCGWSPFFAENNQKMYQKIAFGKVKFPRDVLSQEGRSF 643

  Fly  1796 LKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFT- 1859
            :||||.::...|:|: .....::..|.||..|||..|::::|.|||||.:....||..||..||
Yeast   644 VKGLLNRNPKHRLGA-IDDGRELRAHPFFADIDWEALKQKKIPPPFKPHLVSETDTSNFDPEFTT 707

  Fly  1860 ---------RERVRLTPIDKEILASMDQKQFHGFTYTN 1888
                     :..:..||:...:     |.:|.|||:.:
Yeast   708 ASTSYMNKHQPMMTATPLSPAM-----QAKFAGFTFVD 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	100/261 (38%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	123/333 (37%)
SCH9	NP_012075.1	YPK1_N_like	181..407	CDD:212165	46/264 (17%)
SCH9	NP_012075.1	STKc_Sck1_like	418..738	CDD:270738	122/327 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910