Protein Alignment Pkcdelta and CBK1

DIOPT Version :10

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: NP_014238.3
• Gene: CBK1 / 855561
• SGDID: S000005105
• Length: 756
• Species: Saccharomyces cerevisiae
• Alignment Length: 829
• Identity: 192/829 - (23%)
• Similarity: 329/829 - (39%)
• Gaps: 231/829 - (27%)

  Fly  1195 SPNKQQALQLQQQHEEQQRQQQQQATNAS------SPAATGDATT---------------TPTTI 1238
            :|.......:.||.::|.:||||.|...:      .|.|.|.::.               ...|.
Yeast    12 APTSGHGYYMSQQQDQQHQQQQQYANEMNPYQQIPRPPAAGFSSNYMKEQGSHQSLQEHLQRETG 76

  Fly  1239 TIGVAAVNVAAVAVVASAAA----AAATDAAADATTSLS-----SNNS-----CGEGVGNNLSKF 1289
            .:|....:|.|:...|:...    ||:.........|:.     :|||     .|.|.||
Yeast    77 NLGSGFTDVPALNYPATPPPHNNYAASNQMINTPPPSMGGLYRHNNNSQSMVQNGNGSGN----- 136

  Fly  1290 ATVSNLAQCLRDVDAELDDYIPSSAENSQEDDDDDDDGSGSSSDDYSSVDGCANL-----SASMK 1349
            |.:..|:.....:::|.:..:..|:.:|..........:||.|....||.....|     :..::
Yeast   137 AQLPQLSPGQYSIESEYNQNLNGSSSSSPFHQPQTLRSNGSYSSGLRSVKSFQRLQQEQENVQVQ 201

  Fly  1350 KKL----RKEKKKQKAKAAAAAEAKRFDPHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKREKI 1410
            ::|    ::..::|:.:.....:.::....:.::|....:...:::..:.|:
Yeast   202 QQLSQAQQQNSRQQQQQLQYQQQQQQQQQQQHMQIQQQQQQQQQQQQSQSPV------------- 253

  Fly  1411 VYSDENTDDESGSEEGSGGSLDEDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLD 1475
                     :||...|:                .|:........||     :||.....|..|
Yeast   254 ---------QSGFNNGT----------------ISNYMYFERRPDL-----LTKGTQDKAAAV-- 286

  Fly  1476 SSNSSGSNAGTLSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLE---TSY 1537
                      .|.:.:....|            ::.:...|:...|           ||   ||:
Yeast   287 ----------KLKIENFYQSS------------VKYAIERNERRVE-----------LETELTSH 318

  Fly  1538 TYSQFQKSGRFTAPATVIPRF-----KNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCL 1597
            .:|:.:||.:.::......:|     ...|::|||.:.|:|||:||:|.|.:.:||...||:|.|
Yeast   319 NWSEERKSRQLSSLGKKESQFLRLRRTRLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTL 383

  Fly  1598 KKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRF 1662
            .|..:.:.|.:.....||.||| |:..|::..|:.:||...:|:.:||:|.|||||..:.....|
Yeast   384 LKSEMYKKDQLAHVKAERDVLA-GSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLF 447

  Fly  1663 SEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGM---------------- 1711
            :|:..|||.||.|..::.:||.|.|:||:|.||:|:|..||::::|||:
Yeast   448 TEDVTRFYMAECILAIETIHKLGFIHRDIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKL 512

  Fly  1712 ----------CKLQIYLDKTAD-----------------------------------SFCGTPDY 1731
                      .|...|...|.|                                   |..|||||
Yeast   513 LQQDEATNGISKPGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDY 577

  Fly  1732 MAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICN--EIPWFP--VYISAEA 1792
            :||||...:.|.|..||||.|.::||.|||..||......|.:..|.|  :...||  ::||.||
Yeast   578 IAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEA 642

  Fly  1793 TGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYF--D 1855
            ..:::.|| ....:|:| ::..|.:|..|.|||.:||..:  ||:|.|:.|::....||::|  |
Yeast   643 EDLIRRLL-THADQRLG-RHGGADEIKSHPFFRGVDWNTI--RQVEAPYIPKLSSITDTRFFPTD 703

  Fly  1856 RV-----------FTRERVRLT------PIDKEILASMDQKQFHGFTYT 1887
            .:           ..::|.::|      |:.:::       .|.|:||:
Yeast   704 ELENVPDSPAMAQAAKQREQMTKQGGSAPVKEDL-------PFIGYTYS 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904
		STKc_nPKC_theta_like	1570..1889	CDD:270744	124/402 (31%)
CBK1	NP_014238.3	MobB_CBK1	269..341	CDD:439268	18/111 (16%)
		STKc_NDR_like_fungal	350..748	CDD:270778	127/408 (31%)