DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and Prkci

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_114448.1	Gene:	Prkci / 84006	RGDID:	620961	Length:	596	Species:	Rattus norvegicus

Alignment Length:	384	Identity:	167/384 - (43%)
Similarity:	232/384 - (60%)	Gaps:	26/384 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly  1516 NDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKV 1580
            |.|..|........|:.:.|       ::||:.::         :..:.||..|.|:|:||:.||
  Rat   220 NPSSHESLDQVGEEKEAMNT-------RESGKASS---------SLGLQDFDLLRVIGRGSYAKV 268

  Fly  1581 LLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVME 1645
            ||..|:.|...||:|.:||::|.:|:|:|....|:.|....:.||:|..|...|||||.||||:|
  Rat   269 LLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIE 333

  Fly  1646 YLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFG 1710
            |:||||||||:|...:..||.||||.|||...|.:||::|||||||||||||||.|||:::.|:|
  Rat   334 YVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG 398

  Fly  1711 MCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPF---SGCD--- 1769
            |||..:....|..:|||||:|:||||::||.|..:||||:.|||::||:.|:|||   ...|
  Rat   399 MCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPD 463

  Fly  1770 ---EDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQ-YSPAGDIADHIFFRPIDWG 1830
               ||.||..|..:....|..:|.:|..:||..|.||..:|:|.. .:...||..|.|||.:||.
  Rat   464 QNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWD 528

  Fly  1831 LLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTYTNP 1889
            ::|::|:.|||||.:........||..||.|.|:|||.|.:|:..:||.:|.||.|.||
  Rat   529 MMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	128/267 (48%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	155/328 (47%)
Prkci	NP_114448.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Regulatory domain. /evidence=ECO:0000250	2..253		7/48 (15%)
		Required for interaction with RAB2. /evidence=ECO:0000250	2..28
		PB1_aPKC	26..108	CDD:99725
		Interaction with PARD6A. /evidence=ECO:0000250	72..91
		Pseudosubstrate. /evidence=ECO:0000250	125..134
		C1_aPKC	139..193	CDD:410344
		STKc_aPKC_iota	233..596	CDD:270769	164/371 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840