DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and prkca

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	XP_031750036.1	Gene:	prkca / 780209	XenbaseID:	XB-GENE-5942870	Length:	692	Species:	Xenopus tropicalis

Alignment Length:	384	Identity:	201/384 - (52%)
Similarity:	253/384 - (65%)	Gaps:	25/384 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly  1520 FEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVI-------PRFKNYSVD-----DFHFLAVL 1572
            || ||.|:..|       .....||:....|...||       |...:.::|     ||.||.||
Frog   309 FE-GTVPARDK-------VVPPVQKAKLGPAGNKVISPTDERRPYVPSNNIDSVRLTDFSFLMVL 365

  Fly  1573 GKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTE 1637
            ||||||||:|||.:.....:|||.||||||::||||:.|::|::||||..|.|:|.||...|||.
Frog   366 GKGSFGKVMLAERKGADELFAIKILKKDVVIQDDDVECTMVEKRVLALQGKPPFLTHLHSCFQTV 430

  Fly  1638 SHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEG 1702
            ..|:|||||:||||||:|||:.|:|.|.:|.||.|||..||.|||||||:|||||||||:||.||
Frog   431 DRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISVGLFFLHKKGIVYRDLKLDNVMLDSEG 495

  Fly  1703 HVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSG 1767
            |::||||||||..:....|..:|||||||:|||||..:.|.::||||::||||||||.||.||.|
Frog   496 HIKIADFGMCKEHMVDGVTTRTFCGTPDYIAPEIIAYQPYGRSVDWWAYGVLLYEMLAGQPPFDG 560

  Fly  1768 CDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAG--DIADHIFFRPIDWG 1830
            .||||||.||......:|..:|.||..|.|||:.|...||:|.  .|.|  ||.:|.|||.|||.
Frog   561 EDEDELFQSIMEHNVSYPKSMSKEAVSICKGLMTKHPVKRLGC--GPEGERDIREHTFFRRIDWE 623

  Fly  1831 LLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTYTNP 1889
            .|:.|:|:|||||:|... ..:.||:.|||.:..|||.|:.::|::||..|.||:|.||
Frog   624 KLQNREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQADFEGFSYINP 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	154/259 (59%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	182/320 (57%)
prkca	XP_031750036.1	C1_cPKC_rpt1	39..96	CDD:410383
		C1_cPKC_rpt2	106..159	CDD:410386
		C2_PKC_alpha_gamma	163..293	CDD:175992
		STKc_cPKC_alpha	348..688	CDD:270766	189/337 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010