DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and pkn2a

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	XP_700704.3	Gene:	pkn2a / 571965	ZFINID:	ZDB-GENE-061207-42	Length:	970	Species:	Danio rerio

Alignment Length:	929	Identity:	263/929 - (28%)
Similarity:	410/929 - (44%)	Gaps:	168/929 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1051 SP--EQQQATAAAVETKINKTTDKE----QQQQQQQQQQQQAQQQQQQLIDTAATLVPQTETK-- 1107
            ||  |.:..|:::....:.|..|.|    |..:...|.......:.::|:.||..::..::||
Zfish   112 SPKSESRTCTSSSRLAALKKQNDIELKVKQGAENMIQMYSNGSSKDRKLLATAQQMLQDSKTKIE 176

  Fly  1108 ---TKLTEAAEPTGKSKVQSPNTTKP---------------------KSAGKTNVGKKKAATPAA 1148
               .::.:|::.:..|...:....||                     .:.|..||.|...:...|
Zfish   177 FIRMQILKASQTSELSFDNNDVIAKPIISPLDLRVEELCHHTRIEFAVAEGAKNVMKLLGSGKLA 241

  Fly  1149 AAAAAAAAAPAAATATEAVTALSES-----NVTPINADQFITLAPTKAAKTSP--NKQQALQLQQ 1206
            ...|.:.|......:::.:..|..|     |..|.|..:...:....:..:||  :.:|:....|
Zfish   242 EKRAHSEAQARFNESSQKLDLLKYSLEQRLNELPKNHPKCSLIMEELSLMSSPALSPRQSFISTQ 306

  Fly  1207 QHEEQQRQQQQQATNASSPAATGDATTTPTTITIGVAAVN-------VAAVAVVASAAAAAATDA 1264
            .|....:.|.               :|.|..:| |...|.       :.:|...:.|.:......
Zfish   307 NHNSTVKNQY---------------STKPAALT-GKLEVRLMGCQDLLESVPGRSKATSVPLPGW 355

  Fly  1265 AADATTS--LSSNNSCGEGVGNNLSKFATVSNLAQCLRDVDAEL---DDYIPSSAENSQEDDDDD 1324
            :...|.|  :|..|..|..| .||||...:||....:..:|..:   ..:.|.|.::..:....:
Zfish   356 SPSETRSSFMSRGNRRGTSV-RNLSKNDDLSNEISAVLKLDNTVVGQTSWKPVSNQSWDQKFTLE 419

  Fly  1325 DDGSGSSS-----DDYSSVDGCANLSASMKKKLRKEKKKQ----KAKAAAAAEAKRFDP--HKKI 1378
            .|.|....     .|:.|:  ||.....::..|..::...    :.:....||...|:|  .::.
Zfish   420 LDRSRELEISVYWRDWRSL--CAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRT 482

  Fly  1379 KIDTTNKCYVKEE------APRYPLVATPRPLWKR--EKIVYSDENTDDESGSEEGSGGSLDEDS 1435
            |:....|.:.|::      ||:..:     ..|.|  .:.:.|..|:.....:|.|.
Zfish   483 KLQRQKKIFSKQQGRTFLRAPQMSI-----GTWGRLVRRAIPSPNNSFSPLAAETGH-------- 534

  Fly  1436 DDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATT-----------VL--DSSNSSGSNAGTL 1487
                        ||...:..|.:..:|||......||           ||  |..::.....|.|
Zfish   535 ------------SSHPGTPALRSDPIVTKLDFDRDTTPKNYSPVSVREVLPEDKISNKERERGAL 587

  Fly  1488 SVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPS-----SPKKMLETSYTYSQFQKSGR 1547
            :         ..|..:...|||..|  ..:...|..|.||     :.:|..|......||
Zfish   588 T---------AFAYRNDRNSIIVQS--GLEEIVEHDTPPSALQLINVQKSTEIRDEEEQF----- 636

  Fly  1548 FTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTL 1612
                        ::|:.||..:||||:|.||||||||...|...:|||.|||..::..|:|:|.:
Zfish   637 ------------HFSLKDFKCVAVLGRGHFGKVLLAEYTITGEMFAIKALKKGDIVARDEVESLM 689

  Fly  1613 IERKVLAL--GTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEII 1675
            .|:::...  ..:||:|.:||..|||:.|:.|||||..|||||.|| .:..|||.||.||.|.::
Zfish   690 CEKRIFETVNSVRHPFLVNLFACFQTKDHVCFVMEYAAGGDLMMHI-HADVFSEPRATFYAACVV 753

  Fly  1676 SGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQI-YLDKTADSFCGTPDYMAPEIIKG 1739
            .||:|||:..|:||||||||:|||.||.|:|||||:||..: |.|:|: :|||||:::|||::..
Zfish   754 LGLQFLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYRDRTS-TFCGTPEFLAPEVLTE 817

  Fly  1740 EKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDY 1804
            ..|.:.||||..|||::|||:|:|||.|.||:|:|.||.|:...:|..:|.||..|::.||.::.
Zfish   818 TSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRVLSTEAISIMRRLLRRNP 882

  Fly  1805 TKRIGSQYSPAGDIADHIFFRPIDW-GLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLT-P 1867
            .:|:|:....|.|:..|:|||.||| |||.|: ::|||.|.::...|...||..||.|...|| |
Zfish   883 ERRLGAAERDAEDVKKHLFFRDIDWDGLLAKK-VKPPFVPTIQCSSDVSNFDDEFTSEAPVLTPP 946

  Fly  1868 IDKEILASMDQKQFHGFTY 1886
            .:...|...:|..|..|.|
Zfish   947 REPRPLNQHEQDLFTDFDY 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	127/260 (49%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	154/322 (48%)
pkn2a	XP_700704.3	HR1_PKN_1	29..94	CDD:212012
		HR1	116..189	CDD:294066	13/72 (18%)
		HR1	201..274	CDD:294066	12/72 (17%)
		C2_PKN-like	387..468	CDD:176069	10/82 (12%)
		STKc_PKN	643..968	CDD:270741	155/326 (48%)
		S_TKc	643..902	CDD:214567	127/260 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583295
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840