DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and pkn1a

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	XP_005160107.3	Gene:	pkn1a / 560840	ZFINID:	ZDB-GENE-061207-17	Length:	967	Species:	Danio rerio

Alignment Length:	935	Identity:	247/935 - (26%)
Similarity:	383/935 - (40%)	Gaps:	215/935 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1046 GQPAKSPEQQQATAAA-----VETKINK-------------TTDKEQQQQQQQQQQ--------- 1083
            |..::|...::..||.     :|.|:.:             |.||:..|..||..|
Zfish   153 GAESRSSAHKERIAALERQLNIELKVKQGAENMIPIYTNGSTKDKKMLQTAQQMLQDSKTKIDII 217

  Fly  1084 ----QQAQQQQQQLIDTAATLVP------------QTETKTKLTEAAEPT----GKSKVQSPNTT 1128
                ::|.|..:...||.....|            ....:..:.|.|:..    |.||||.....
Zfish   218 RMQIRKAVQAYEHNDDTQGKPDPCGMELRIEELRHHYRVEHAVAEGAKNVLRLLGASKVQDKKAM 282

  Fly  1129 K---------------------------PKSAGKTNVGKKKAATPAAAAAAAAAAAP----AAAT 1162
            .                           |:...|.:|.|::....::.|.::..:||    ..:|
Zfish   283 SEAQCRLSESSQRLDLLRDSLDRRLAELPEDHPKASVIKEELVLASSPAFSSQHSAPYLHNQYST 347

  Fly  1163 ATEAVTALSESNVTPINADQFITLAPTKAAKTSPNKQQALQLQQQHEEQQRQQQQQATNASSPAA 1227
            .::.........||.:.....:.:.|.:    |...|..|......|.:...:..:...:.|.:.
Zfish   348 LSKPSPLTGRLQVTLLGCMGLLEVVPGR----SRGSQVVLPCYSPGEGRSFMRSGKGLYSRSGSV 408

  Fly  1228 TGDATTTPTTITIGVAAVNVAAVAVVASAAAAAATDAAADATTSLSSNNSCGEGVGNNLSKFATV 1292
            :|........::..|:||......||...|.....:...|.|.
Zfish   409 SGKTPLKTDELSSDVSAVLKLDNTVVCQTAWKMVGEQGWDQTF---------------------- 451

  Fly  1293 SNLAQCLRDVDAELDDYIPSSAENSQEDDDDDDDGSGSSSDDYSSVDGCANLSASMKKKLRKEKK 1357
              :.:..|..:.|:..|                      ..||.|:  ||.....::..|..:|.
Zfish   452 --IIELERSREMEIAVY----------------------WRDYRSL--CALKFLKLEDFLDNQKH 490

  Fly  1358 K----QKAKAAAAAEAKRFDPHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKREKIVYSDENTD 1418
            |    .:.:....||...|:|             |.|..||.          ||:|.|:|
Zfish   491 KVQLELEPQGLLLAEVTFFNP-------------VIERVPRL----------KRQKNVFS----- 527

  Fly  1419 DESGSEEGSGGSLDEDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNSSGSN 1483
                .::|.                 :...:...:.|:.....:.:    ||...::::.:...|
Zfish   528 ----KQQGK-----------------AFLRARQMNVDIGTFVRLLR----NAIPTVNNTGTYSPN 567

  Fly  1484 A-----GTLSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAP--SSPKKMLETSYTYSQ 1541
            |     |.:||..................:..:||.......|..:||  ::|.:    :::.|.
Zfish   568 AHTLQTGEISVEKLSLDFDSPMKVDIRREVTDISTPERQPSTEPLSAPDVTTPIR----THSLSS 628

  Fly  1542 FQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDD 1606
            .||.             .:.|:.||..:||||:|.||||||||.:.:...||||.|||..::..|
Zfish   629 KQKK-------------TSLSLQDFRLIAVLGRGHFGKVLLAEYKKSGSMYAIKALKKGDIVARD 680

  Fly  1607 DVDSTLIERKVLAL--GTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARF 1669
            :|:|.:.|:::...  |.:||:|.:||..|||..|:.|||||..|||||.|| .:..|:|.||.|
Zfish   681 EVESLMCEKRIFEAVNGAQHPFLVNLFACFQTPEHVCFVMEYTAGGDLMMHI-HADVFTEPRAVF 744

  Fly  1670 YGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAP 1734
            |.|.::.||:|||...|:||||||||:|||.||:|:|||||:||..:.......:|||||:::||
Zfish   745 YSACVVLGLQFLHDNKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTSTFCGTPEFLAP 809

  Fly  1735 EIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGL 1799
            |::....|.:.||||..|||:||||:|:|||.|.||:|:|.||.|:...:|.::||||.||::.|
Zfish   810 EVLTDTSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRL 874

  Fly  1800 LEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVR 1864
            |.::..:|:||....|.|:....|||.:||..|..|::.|||.|.:....|...||..||.|...
Zfish   875 LRRNPERRLGSSEKDAEDVKKQPFFRNMDWEALLLRKLPPPFIPSIGGKEDVSNFDEEFTTEAPT 939

  Fly  1865 LT-PIDKEILASMDQKQFHGFTYTN 1888
            || |.:..:|:..||..|..|.|.:
Zfish   940 LTPPREPRVLSRKDQDSFRDFDYVS 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	127/259 (49%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	152/322 (47%)
pkn1a	XP_005160107.3	HR1_PKN_1	71..136	CDD:212012
		HR1_PKN1_2	156..233	CDD:212020	14/76 (18%)
		HR1	237..310	CDD:320753	8/72 (11%)
		C2	421..508	CDD:326325	21/134 (16%)
		STKc_PKN	640..965	CDD:270741	153/326 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.870