DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and PKN2

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_006247.1	Gene:	PKN2 / 5586	HGNCID:	9406	Length:	984	Species:	Homo sapiens

Alignment Length:	986	Identity:	276/986 - (27%)
Similarity:	418/986 - (42%)	Gaps:	238/986 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1017 TATPTTPNTP------TTATGKSK-LNETAGPKINSGQPAKSPEQQQATAAAVETKINKTT---- 1070
            |..|.||:||      :|:..:.| |.:....::...|.|::..|..:..::.:.|::.|.
Human   116 TDCPRTPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLL 180

  Fly  1071 -DKEQQQQQQQQQQQQAQQQQQQLIDTAATLVPQTETKTK------LTEAAEPTGKSKVQSPNTT 1128
             |.:.:.:..:.|..||.|..:...|.|..::...|.:.:      ..|.|...|...|.
Human   181 QDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVM----- 240

  Fly  1129 KPKSAGKTNVGKKKAATPAAAAAAAAAAAPAAATATEAVTALSES-----NVTPINADQ----FI 1184
              |..|...|..:||.:.|.|         ....:::.:..|..|     |..|.|..:    ..
Human   241 --KLLGSGKVTDRKALSEAQA---------RFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIE 294

  Fly  1185 TLAPTKAAKTSPNKQQALQLQQQHEEQQRQQQQQATNASSPAATGDATTTPTTITIGVAAV--NV 1247
            .|:...|:.|...:|..:..|.|:           :..|.|||   .|.|.....:|...:  ||
Human   295 ELSLVAASPTLSPRQSMISTQNQY-----------STLSKPAA---LTGTLEVRLMGCQDILENV 345

  Fly  1248 ----AAVAVVASAAAAAATDAAADATTSLSSNNSCGEGVGNNLSKFATVSNLAQCLRDVDA--EL 1306
                .|.:|.....:.:.|.::..:.||.|.:     |...||.|...:||      ||.|  :|
Human   346 PGRSKATSVALPGWSPSETRSSFMSRTSKSKS-----GSSRNLLKTDDLSN------DVCAVLKL 399

  Fly  1307 DDYI-------PSSAENSQEDDDDDDDGSGSSS-----DDYSSVDGCA----------------- 1342
            |:.:       |.|.::..:....:.|.|....     .|:.|:  ||
Human   400 DNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSL--CAVKFLRLEDFLDNQRHGM 462

  Fly  1343 -----------------NLSASMKKKLRKEKK---KQKAKAAAAAEAKRFDPHKKIKIDTTNKCY 1387
                             |.....:.||:::||   ||:.|....|      |...|.|.|..:..
Human   463 CLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRA------PQMNINIATWGRLV 521

  Fly  1388 ------------VKEEAP----------RYPLVATPRPLWKREKIVYSDENTDDESGSEEGSGGS 1430
                        ...:||          |.|.:|.|.......|:.:..|.....:.....|.|.
Human   522 RRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGE 586

  Fly  1431 LDEDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNSSGSNAGTLSVPSAGSG 1495
            :||.|:                       ..|......::.||.|..|...
Human   587 IDESSE-----------------------LRVLDIPGQDSETVFDIQNDRN-------------- 614

  Fly  1496 SGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQK------SGRFTAPATV 1554
                       ||:..|        :....|.:|:..||    ||..|:      ..||
Human   615 -----------SILPKS--------QSEYKPDTPQSGLE----YSGIQELEDRRSQQRF------ 650

  Fly  1555 IPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLA 1619
                 .:::.||...||||:|.||||||||.::|...:|||.|||..::..|:|||.:.|:::..
Human   651 -----QFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFE 710

  Fly  1620 L--GTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLH 1682
            .  ..:||:|.:||..|||:.|:.|||||..|||||.|| .:..|||.||.||.|.::.||::||
Human   711 TVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVLGLQYLH 774

  Fly  1683 KKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQI-YLDKTADSFCGTPDYMAPEIIKGEKYNQNV 1746
            :..|:||||||||:|||.||.|:|||||:||..: |.|:|: :|||||:::|||::....|.:.|
Human   775 EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTS-TFCGTPEFLAPEVLTETSYTRAV 838

  Fly  1747 DWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQ 1811
            |||..|||:||||:|:|||.|.||:|:|.||.|:...:|.::|.||..|::.||.::..:|:|:.
Human   839 DWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAS 903

  Fly  1812 YSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLT-PIDKEILAS 1875
            ...|.|:..|.|||.|||..|..::::|||.|.::...|...||..||.|...|| |.:..||:.
Human   904 EKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSE 968

  Fly  1876 MDQKQFHGFTY 1886
            .:|:.|..|.|
Human   969 EEQEMFRDFDY 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	128/260 (49%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	153/321 (48%)
PKN2	NP_006247.1	HR1_PKN_1	42..107	CDD:212012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..133		6/16 (38%)
		HR1	130..201	CDD:294066	13/70 (19%)
		HR1_PKN2_3	209..282	CDD:212025	15/88 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..383		7/36 (19%)
		Necessary to rescue apical junction formation. /evidence=ECO:0000250	382..463		18/88 (20%)
		C2_PKN-like	390..473	CDD:176069	15/90 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..584		2/25 (8%)
		STKc_PKN	657..982	CDD:270741	154/325 (47%)
		S_TKc	662..916	CDD:214567	126/255 (49%)
		Necessary for the catalytic activity	917..977		22/59 (37%)
		Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA	978..984		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149228
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870