Protein Alignment Pkcdelta and PRKCG

DIOPT Version :9

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0259680
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: NP_001303258.1
• Gene: PRKCG / 5582
• HGNCID: 9402
• Length: 710
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 230/541 - (42%)
• Similarity: 290/541 - (53%)
• Gaps: 79/541 - (14%)

  Fly  1373 DPHKKIKI--DTTNKCYVKEEAPRYPLVATPRPLWKREKIVYSDENTDDESGSEEGSGGSLDEDS 1435
            ||:.|:|:  |..|....|....:    ||..|:| .|..|::.:..|.|...      |::...
Human   193 DPYVKLKLIPDPRNLTKQKTRTVK----ATLNPVW-NETFVFNLKPGDVERRL------SVEVWD 246

  Fly  1436 DDESGGEECSSTSSSASSEDLDAVA------MVTKAGSSNATTVLDSSNSS------GSNAGTLS 1488
            .|.:...:.....|...||.|.|..      :..:.|......|.|:.|.|      ..|.....
Human   247 WDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPLEL 311

  Fly  1489 VPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKS-GRFTAPA 1552
            ......|.......|.|||                  |:.||:..        |..| ||.
Human   312 YERVRMGPSSSPIPSPSPS------------------PTDPKRCF--------FGASPGRL---- 346

  Fly  1553 TVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKV 1617
                     .:.||.||.||||||||||:|||.|.:...||||.|||||:::|||||.||:|::|
Human   347 ---------HISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRV 402

  Fly  1618 LALGTKHP-----YLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISG 1677
            ||||.:.|     :|..|..||||...|:|||||:.|||||:|||:.|:|.|..|.||.|||..|
Human   403 LALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIG 467

  Fly  1678 LKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKY 1742
            |.|||.:||||||||||||:||.|||::|.||||||..::...|..:|||||||:|||||..:.|
Human   468 LFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPY 532

  Fly  1743 NQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKR 1807
            .::||||||||||||||.||.||.|.||:|||.:|..:...:|..:|.||..|.||.|.|...||
Human   533 GKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKR 597

  Fly  1808 IGSQYSPAGD--IADHIFFRPIDWGLLEKRQIEPPFKPQVKHPL--DTQYFDRVFTRERVRLTPI 1868
            :||  .|.|:  |..|.|||.|||..||:.:|.|||:|:   |.  ..:.||:.|||....|||.
Human   598 LGS--GPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPR---PCGRSGENFDKFFTRAAPALTPP 657

  Fly  1869 DKEILASMDQKQFHGFTYTNP 1889
            |:.:|||:||..|.||||.||
Human   658 DRLVLASIDQADFQGFTYVNP 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	154/264 (58%)
		STKc_nPKC_theta_like	1570..1889	CDD:270744	184/327 (56%)
PRKCG	NP_001303258.1	C1_1	36..88	CDD:278556
		C1_1	101..153	CDD:278556
		C2_PKC_alpha_gamma	158..289	CDD:175992	23/106 (22%)
		S_TKc	351..614	CDD:214567	154/264 (58%)
		STKc_cPKC	354..677	CDD:270739	185/327 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149254
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850