DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkcdelta and PRKCB

DIOPT Version :9

Sequence 1:NP_572797.3 Gene:Pkcdelta / 32191 FlyBaseID:FBgn0259680 Length:1894 Species:Drosophila melanogaster
Sequence 2:NP_002729.2 Gene:PRKCB / 5579 HGNCID:9395 Length:673 Species:Homo sapiens


Alignment Length:357 Identity:193/357 - (54%)
Similarity:247/357 - (69%) Gaps:15/357 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly  1534 ETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLK 1598
            :|:.|.|:|..:|.       ..|.|   :.||:||.||||||||||:|:|.:.|...||:|.||
Human   320 KTTNTVSKFDNNGN-------RDRMK---LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILK 374

  Fly  1599 KDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFS 1663
            ||||::||||:.|::|::||||..|.|:|..|...|||...|:|||||:||||||:|||:.|||.
Human   375 KDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFK 439

  Fly  1664 EERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGT 1728
            |..|.||.|||..||.||..|||||||||||||:||.|||::||||||||..|:...|..:||||
Human   440 EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGT 504

  Fly  1729 PDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEAT 1793
            |||:|||||..:.|.::||||:|||||||||.||:||.|.||||||.||......:|..:|.||.
Human   505 PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAV 569

  Fly  1794 GILKGLLEKDYTKRIGSQYSPAG--DIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDR 1856
            .|.|||:.|...||:|.  .|.|  ||.:|.|||.|||..||:::|:||:||:. ...:.:.|||
Human   570 AICKGLMTKHPGKRLGC--GPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKA-CGRNAENFDR 631

  Fly  1857 VFTRERVRLTPIDKEILASMDQKQFHGFTYTN 1888
            .|||....|||.|:|::.::||.:|.||::.|
Human   632 FFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVN 663

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PkcdeltaNP_572797.3 S_TKc 1566..1824 CDD:214567 155/259 (60%)
STKc_nPKC_theta_like 1570..1889 CDD:270744 182/321 (57%)
PRKCBNP_002729.2 C1_cPKC_rpt1 35..92 CDD:410383
C1_cPKC_rpt2 102..155 CDD:410386
C2_PKC_alpha_gamma 159..289 CDD:175992
STKc_cPKC_beta 341..663 CDD:270767 185/324 (57%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149250
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D143719at33208
OrthoFinder 1 1.000 - - FOG0000117
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R891
SonicParanoid 1 1.000 - - X125
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.880

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