DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and PRKCA

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_002728.2	Gene:	PRKCA / 5578	HGNCID:	9393	Length:	672	Species:	Homo sapiens

Alignment Length:	647	Identity:	243/647 - (37%)
Similarity:	327/647 - (50%)	Gaps:	110/647 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1298 CLRDVDAELDDYIPSSAENSQEDDDDDDD-----------GSGSSSDDYSSV------DG--CAN 1343
            |...|.....:::..|...:.:..|.||.           ||.:..|...|:      .|  |..
Human    70 CCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDT 134

  Fly  1344 LSASMKKKL-----------RKEKKKQ---KAKAA------AAAEAKRF---------DPHKKIK 1379
            ...::.|:.           ..||:.:   ||:.|      ...:||..         ||:.|:|
Human   135 CDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLK 199

  Fly  1380 I--DTTNKCYVKEEAPRYPLVATPRPLWKRE---KIVYSDENTDDESGSEEGSGGSLDEDSDDES 1439
            :  |..|:...|.:..|    :|..|.|...   |:..||:   |...|.|      ..|.|..:
Human   200 LIPDPKNESKQKTKTIR----STLNPQWNESFTFKLKPSDK---DRRLSVE------IWDWDRTT 251

  Fly  1440 GGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNSSGSNAGTLSVPSAGSGSGGGASTSS 1504
            ..:...|.|...|.        :.|..:|....:|:.......|     ||.......|......
Human   252 RNDFMGSLSFGVSE--------LMKMPASGWYKLLNQEEGEYYN-----VPIPEGDEEGNMELRQ 303

  Fly  1505 SPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFL 1569
            .....::....|..     .:||..:|.                  |:..:.|.|   :.||:||
Human   304 KFEKAKLGPAGNKV-----ISPSEDRKQ------------------PSNNLDRVK---LTDFNFL 342

  Fly  1570 AVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTF 1634
            .||||||||||:||:.:.|...||||.||||||::||||:.|::|::||||..|.|:|..|...|
Human   343 MVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCF 407

  Fly  1635 QTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLD 1699
            ||...|:|||||:||||||:|||:.|:|.|.:|.||.|||..||.||||:||||||||||||:||
Human   408 QTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD 472

  Fly  1700 YEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSP 1764
            .|||::||||||||..:....|..:|||||||:|||||..:.|.::||||::||||||||.||.|
Human   473 SEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPP 537

  Fly  1765 FSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAG--DIADHIFFRPI 1827
            |.|.||||||.||......:|..:|.||..:.|||:.|...||:|.  .|.|  |:.:|.|||.|
Human   538 FDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGC--GPEGERDVREHAFFRRI 600

  Fly  1828 DWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTYTNP 1889
            ||..||.|:|:|||||:|... ..:.||:.|||.:..|||.|:.::|::||..|.||:|.||
Human   601 DWEKLENREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	152/259 (59%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	181/320 (57%)
PRKCA	NP_002728.2	C1_1	37..89	CDD:278556	3/18 (17%)
		C1_1	102..154	CDD:278556	7/51 (14%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	31/155 (20%)
		STKc_cPKC_alpha	328..668	CDD:270766	189/340 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149248
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.880