DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and prkcaa

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	XP_021332537.1	Gene:	prkcaa / 497384	ZFINID:	ZDB-GENE-050208-100	Length:	679	Species:	Danio rerio

Alignment Length:	562	Identity:	226/562 - (40%)
Similarity:	294/562 - (52%)	Gaps:	129/562 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1373 DPHKKIKI--DTTNKCYVKEEAPRYPLVATPRPLWKRE---KIVYSDEN--------------TD 1418
            ||:.|:|:  |..|:...|.:..|..|    .|.|...   |:..:|::              .:
Zfish   191 DPYVKLKLIPDPKNETKQKTKTIRSSL----NPTWNETFTFKLKPADKDRRLAVEVWDWDRTTRN 251

  Fly  1419 DESGS----------------------EEGSGGSL---DEDSDDESGGEECSSTSSSASSEDLDA 1458
            |..||                      |||...::   |||..|    .|........:.|||:.
Zfish   252 DFMGSMSFGVSELMKSPVCGWYKMLNQEEGEYYNVPIPDEDDPD----TELRQKFEDETLEDLEQ 312

  Fly  1459 VAMVTKAGSSNAT-TVLDSSNSSGSNAGTLSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEG 1522
            :|   |.|..... |.||.|.||                    .|||:...:|:|
Zfish   313 IA---KLGPPKKNITALDDSGSS--------------------ITSSNVDNVRLS---------- 344

  Fly  1523 GTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRD 1587
                                                      ||:|||||||||||||:|||::.
Zfish   345 ------------------------------------------DFNFLAVLGKGSFGKVMLAEMKS 367

  Fly  1588 TTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDL 1652
            :...:|||.||||||::||||:.|::|::|||...|.|:|..|...|||...|:|||||:|||||
Zfish   368 SDELFAIKILKKDVVIQDDDVECTMVEKRVLAQQDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDL 432

  Fly  1653 MFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIY 1717
            |:|||:.|:|.|.:|.||.|||..||.|||||||||||||||||:||.|||::||||||||..|.
Zfish   433 MYHIQQVGKFKEPQAVFYAAEIAVGLFFLHKKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENIV 497

  Fly  1718 LDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIP 1782
            ...|..:|||||||:|||||..:.|.::||||::||||||||.||.||.|.||||||.||.....
Zfish   498 EGVTTRTFCGTPDYIAPEIIAYQPYGRSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNV 562

  Fly  1783 WFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKH 1847
            .:...:|.||..|.|||:.|..:||:|.......||.:|.|||.|||..|..|:::|||||:|..
Zfish   563 SYSKTLSKEAVSICKGLMTKHPSKRLGCGQEGERDIREHAFFRRIDWDRLANREVQPPFKPKVCG 627

  Fly  1848 PLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTYTNP 1889
            . ..:.||:.|||.:.:|||.|:.::|::||..|.|||:.||
Zfish   628 K-GAENFDKFFTRTQPQLTPPDELVIANIDQADFDGFTFVNP 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	152/257 (59%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	179/318 (56%)
prkcaa	XP_021332537.1	C1_1	35..87	CDD:278556
		C1_1	100..150	CDD:278556
		C2_PKC_alpha_gamma	157..287	CDD:175992	19/99 (19%)
		STKc_cPKC_alpha	335..675	CDD:270766	189/387 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583324
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.880