DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkcdelta and wts

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster

Alignment Length:	1364	Identity:	287/1364 - (21%)
Similarity:	455/1364 - (33%)	Gaps:	502/1364 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   689 STSGKSETQKVPSTPLTPTVVKTNQVEAKKVESMDTSSKAPASVI--------SKAAES------ 739
            :|:|:::.       |||......|    .:|...::|.||..||        ...|.|
  Fly    50 ATNGRNDA-------LTPDYHHAKQ----PMEPPPSASPAPDVVIPPPPAIVGQPGAGSISVSGV 103

  Fly   740 ------------PKLKSATDNNK--AKPTMAKKDLPKLKTAEETKLTITTKATTATPTMDSPKTP 790
                        ||:.:|...||  .||::.:.             |.::.....:|.:||
  Fly   104 GVGVVGVANGRVPKMMTALMPNKLIRKPSIERD-------------TASSHYLRCSPALDS---- 151

  Fly   791 QAKEETSQKTESATTSQIKSDT-----------PIALQIKPQEQMKVAAPTTP-----QAKVETP 839
            .|....|....|..|.|..|.|           |     .|....:||.|..|     .....||
  Fly   152 GAGSSRSDSPHSHHTHQPSSRTVGNPGGNGGFSP-----SPSGFSEVAPPAPPPRNPTACSAATP 211

  Fly   840 PKDSP--TRKIVAPTTPQAKVETPTKDSPTRKIVTPTTPQAKVETPTKD-------------SPT 889
            |...|  ::..|...:|......|....||::..:|...|..::.|.:.             ..:
  Fly   212 PPPVPPTSQAYVKRRSPALNNRPPAIAPPTQRGNSPVITQNGLKNPQQQLTQQLKSLNLYPGGGS 276

  Fly   890 RKIVTPTTPQ-------AKVETPTKDSPTRKIVTPTTPQAKVETPTKDSPTRKIATPT---TPQA 944
            ..:|.|..|.       .....|...|.|..:.:..:|....::..:.||:..|.:.|   :|..
  Fly   277 GAVVEPPPPYLIQGGAGGAAPPPPPPSYTASMQSRQSPTQSQQSDYRKSPSSGIYSATSAGSPSP 341

  Fly   945 KAAASTTSPLTTPQKTPQVKAATDESKSTPAAPKTTMAKISMTTMAGTTVAEAGKTISPKGLKQS 1009
            ...:...:||..||  |:|..|..:......:.|:|..:                    |.:.|
  Fly   342 ITVSLPPAPLAKPQ--PRVYQARSQQPIIMQSVKSTQVQ--------------------KPVLQ- 383

  Fly  1010 GNAVAMPTATPTTPNTPTTAT-GKSKLNETAGPKINSGQPAKSPEQQQATAAAVETKINKTTDKE 1073
                     |...|.:|::|: ..|.::..|.|          |...|.:||.|:         :
  Fly   384 ---------TAVAPQSPSSASASNSPVHVLAAP----------PSYPQKSAAVVQ---------Q 420

  Fly  1074 QQQQQQQQQQQQAQQQQQQLIDTAATLVPQTETKTKLTEAAEPTGKSKVQSPNTTKPKSAGKTNV 1138
            |||......|||.|.||.:         |.|.|...|...     .||   ||..:|.|..|:..
  Fly   421 QQQAAAAAHQQQHQHQQSK---------PPTPTTPPLVGL-----NSK---PNCLEPPSYAKSMQ 468

  Fly  1139 GKKKAATPAAAAAAAAAAAPAAATATEAVTALSESNVTPINADQFITLAPTKAAKTSPNKQQALQ 1203
            .|                   |||..:                           :....:||..|
  Fly   469 AK-------------------AATVVQ---------------------------QQQQQQQQQQQ 487

  Fly  1204 LQQQHEEQQRQQQQQATNASSPAATGDATTTPTTITIGVAAVNVAAVAVVASAAAAAATDAAADA 1268
            :|||..:||:|||||.
  Fly   488 VQQQQVQQQQQQQQQQ------------------------------------------------- 503

  Fly  1269 TTSLSSNNSCGEGVGNNLSKFATVSNLAQCLRDVDAELDDYIPSSAENSQEDDDDDDDGSGSSSD 1333
                                       .|.||.:.|:      :..|..|.:.|
  Fly   504 ---------------------------LQALRVLQAQ------AQRERDQRERD----------- 524

  Fly  1334 DYSSVDGCANLSASMKKKLRKEKKKQKAKAAAAAEAKRFDPHKKIKIDTTNKCYVKEEAPRYPLV 1398
                               ::|:::.:.|.|.....::..|
  Fly   525 -------------------QRERERDQQKLANGNPGRQMLP------------------------ 546

  Fly  1399 ATPRPLWKREKIVYSDENTDDESGSEEGSGGSLDEDSDDESGGEECSSTSSSASSEDLDAVAMVT 1463
              |.|        |...|                 :::.|.....|::.:...|:.:|.....:.
  Fly   547 --PPP--------YQSNN-----------------NNNSEIKPPSCNNNNIQISNSNLATTPPIP 584

  Fly  1464 KAGSSNATTVLDSSNSSGSNAGTLSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSS 1528
            .|..:|.::...:::|.|||..|.:..|:.:........|..|...::|....:...|......|
  Fly   585 PAKYNNNSSNTGANSSGGSNGSTGTTASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYS 649

  Fly  1529 P---------------KKMLETSYTYSQFQKSGRFTAPATVIP-------------------RFK 1559
            |               |...:.:|..:|.:|......    :|                   |.|
  Fly   650 PQAFKFFMEQHIENVIKSYRQRTYRKNQLEKEMHKVG----LPDQTQIEMRKMLNQKESNYIRLK 710

  Fly  1560 NYSVDDFHF--LAVLGKGSFGKVLLAELRDTT-YYYAIKCLKKDVVLEDDDVDSTLIERKVLALG 1621
            ...:|...|  |..:|.|:||:|.|....||: :.||:|.|:|..||:.:.|.....||.:||..
  Fly   711 RAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEA 775

  Fly  1622 TKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGI 1686
            ..: ::..|:.:||.:.:|:|||:|:.|||||..:.:.|.|.||.||||.||:...:..:||.|.
  Fly   776 DNN-WVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGF 839

  Fly  1687 IYRDLKLDNVLLDYEGHVRIADFGMC--------------------------------------- 1712
            |:||:|.||:|:|.:||:::.|||:|
  Fly   840 IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTV 904

  Fly  1713 ----KLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSG-----C 1768
                :::.:....|.|..|||:|:|||:::...|.|..|:||.||:|||||:||.||..     .
  Fly   905 LERRRMRDHQRVLAHSLVGTPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLET 969

  Fly  1769 DEDELFWSICNEIPWFP-VYISAEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLL 1832
            .:..:.|.....||  | ..:|.|||.:::.|. ....||:|..   ..::..|.||:.||:.
  Fly   970 QQKVINWEKTLHIP--PQAELSREATDLIRRLC-ASADKRLGKS---VDEVKSHDFFKGIDFA-- 1026

  Fly  1833 EKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMD------------QKQFHGF 1884
            :.|:.:.|:.|::|||.||..||           |:|.|.|.|.|            .:.||||
  Fly  1027 DMRKQKAPYIPEIKHPTDTSNFD-----------PVDPEKLRSNDSTMSSGDDVDQNDRTFHGF 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	100/309 (32%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	122/377 (32%)
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	121/380 (32%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	100/307 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010